For the research of characteristics about penetrating runway obliquely by projectile of anti-runway series warhead, which was at the situation of holding in advance by warhead of former stage, the penetrative process of the tandem warhead was simulated by the finite element code LS-DYNA3D, which considered the different influences about speed, attack angle and medium interface. The conclusion also got the validation of live ammunition experiments. The results of simulation have reference value for design of anti-runway projectile.