Aiming at the need for fast design of fragment warhead, fast design was carried out based on Matlab. According to warhead structure feature and power parameter model, select basic characteristics of warhead to describe warhead structure plan. The system for the fast design of fragment warhead was established, the power parameters were calculated by using engineering model, and the design of fragment warhead was evaluated and optimized quickly. The results show that the system can be applied to design and power analysis of fragment warhead.