Abstract:A systematic study has been carried out to make good use of a Mongolia Pb-Zn ore .At last, the flowsheet of preferential flotation of Cu-Pb, copper flotation with lead depression, zinc flotation from tailing of Cu-Pb preferential flotation was work out. The results show good separation indexes of copper minerals from lead concentrate. A close-circuit test has been conducted on the basis of open-circuit flotation experiments, from which a lead concentrate with 62.46% Pb and 96.37% recovery and a copper concentrate with 27.62% Cu and 66.58% recovery are obtained. This study could provide technical reference for other similar lead-zinc Ores.