夏枯草提取物对链脲菌素致糖尿病ICR小鼠血糖及血脂影响

食品科学 ›› 2006, Vol. 27 ›› Issue (6): 212-215.

夏枯草提取物对链脲菌素致糖尿病ICR小鼠血糖及血脂影响

李晔, 籍保平, 郑杰, 李博, 张晓峰

中国农业大学食品科学与营养工程学院

出版日期:2006-06-15 发布日期:2011-09-22

Effects of Prunella vulgaris L. Extracts on Blood Glucose and Blood Lipid in Streptozotocin-induced Diabetic ICR Mice

LI Ye, JI Bao-Ping, ZHENG Jie, LI Bo, ZHANG Xiao-Feng

College of Food Science and Nutritional Engineering, China Agricultrual University, Beijing 100083, China

Online:2006-06-15 Published:2011-09-22

摘要/Abstract

摘要： 目的:研究夏枯草提取物对链脲菌素致糖尿病ICR小鼠血糖、血脂的影响。方法:采用链脲菌素(Strepotozotocin,STZ)尾静脉注射得到糖尿病模型小鼠,分别以含生药量8、4g/kgbw醇提物、格林苯脲或纯净水进行28d灌胃实验,观察小鼠空腹血糖、血清胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白含量,以及体重、采食量、采水量变化。结果:长期服用夏枯草醇提物(PrunellavulgarisL.extracts,PVE)能缓解糖尿病ICR小鼠体重下降和多饮多食症状,高剂量PVE组小鼠空腹血糖比实验初期降低9.7%,高、低剂量PVE均能显著地降低糖尿病小鼠血清甘油三酯、胆固醇、低密度脂蛋白含量并提高高密度脂蛋白含量,实验证明PVE具有良好的降血糖潜力。

关键词: , 夏枯草, 糖尿病, ICR小鼠, 血糖, 血脂

Abstract: Objective: Study on the effects of Prunella vulgaris L. extracts (PVE) on blood glucose、blood lipid in ICR diabetic mice. Methods: Diabetic models were induced by the i.v. injection of strepotozotocin (STZ) in ICR mice, and were divided into different groups, which were given 8g/kg PVE, 4g/kg PVE, glibenclamide or normal water respectively. Blood glucose, TC, TG, HDL-C, LDL-C and food, water intake and body weight were assaged. Result: After 28d drug administration, symptoms of diabetic mice fed PVE were alleviated obviously. PVE can decrease water, food intake of diabetic mice, and increase their body weight. High dose of PVE lowered the level of blood glucose by 9.7%, and two doses of PVE lowered the levels of TC, TG and LDL- C, but increased the level of HDL-C remarkably. PVE can have the potential hypoglycemic effect and alleviate the diabetic symptoms on diabetic mice.

Key words: Prunella vulgaris L, diabetes mellitus, ICR mice, blood glucose, blood lipid

李晔, 籍保平, 郑杰, 李博, 张晓峰. 夏枯草提取物对链脲菌素致糖尿病ICR小鼠血糖及血脂影响[J]. 食品科学, 2006, 27(6): 212-215.

LI Ye, JI Bao-Ping, ZHENG Jie, LI Bo, ZHANG Xiao-Feng. Effects of Prunella vulgaris L. Extracts on Blood Glucose and Blood Lipid in Streptozotocin-induced Diabetic ICR Mice[J]. FOOD SCIENCE, 2006, 27(6): 212-215.

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