| 运用手性固定相研究外消旋布洛芬的光学分离 |
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| 引用本文： | Dalkeun PARK Joong Kee LEE 等. 运用手性固定相研究外消旋布洛芬的光学分离[J]. 中国化学工程学报, 2002, 10(6): 681-685 |
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| 作者姓名： | Dalkeun PARK Joong Kee LEE 等 |
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| 作者单位： | [1]Nano-EcoResearchCenter,KIST,Seoul136-791,Korea [2]ChemicalEngineeringDepartment,HongikUniversity,Seoul121-791,Korea |
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| 摘 要： | Ibprofen is widely used as a non-steroidal anti-inflammatory drug and poduced as racemic mixture.Its pharmacological activity resides only is S-( )-enantiomer,and R-(-)-enantiomer is not only inactive but also has many side effects.Thus it is necessary to separate Renantiomer from racemic ibuprofen.We studied optical separation of racemic Ibuprofen with chiral high performance liquid chromatography(HPLC).,Out of three different chiral stationary phases,which were selected on the basis of structure and availability,two were found to be effective.There was optimum eluent composition for each stationary phase for good resolution in optical separation.Resolution decreased with increase of eluent flow rate,but effect of injection volume on resolution was insignificant at high eluent flow rate.
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| 关 键 词： | 手性固体相 外消旋布洛芬 光学分离 高效液相色谱 对映体 抗炎药 |
| 修稿时间： | |
Comparative Optical Separation of Racemic Ibuprofen by Using Chiral Stationary Phase |
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| Dalkeun PARK,Joong Kee LEE,So-Young KIM,Taeho SONG,Sung-Sup SUH. Comparative Optical Separation of Racemic Ibuprofen by Using Chiral Stationary Phase[J]. Chinese Journal of Chemical Engineering, 2002, 10(6): 681-685 |
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| Authors: | Dalkeun PARK Joong Kee LEE So-Young KIM Taeho SONG Sung-Sup SUH |
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| Affiliation: | Nano-Eco Research Center, KIST, Seoul 136-791, Korea Chemical Engineering Department, Hongik University, Seoul 121-791, Korea |
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| Abstract: | Ibuprofen is widely used as a non-steroidal anti-inflammatory drug and produced as racemic mixture. Its pharmacological activity resides only in S-(+)-enantiomer, and R-()-enantiomer is not only inactive but also has many side effects. Thus it is necessary to separate R-enantiomer from racemic ibuprofen. We studied optical separation of racemic Ibuprofen with chiral high performance liquid chromatography (HPLC). Out of three different chiral stationary phases, which were selected on the basis of structure and availability, two were found to be ef-fective. There was optimum eluent composition for each stationary phase for good resolution in optical separation. Resolution decreased with increase of eluent flow rate, but effect of injection volume on resolution was insignificant at high eluent flow rate. |
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| Keywords: | ibuprofen enantiomer separation high performance liquid chromatography chiral stationary phase |
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