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| 手性溶剂萃取分离布洛芬对映体 | |
| 引用本文： | 阎建辉,盛盈,黄可龙,唐课文,易建民. 手性溶剂萃取分离布洛芬对映体[J]. 化工学报, 2007, 58(3): 679-684 |
| 作者姓名： | 阎建辉 盛盈 黄可龙 唐课文 易建民 |
| 作者单位： | 湖南理工学院化学化工系,湖南,岳阳,414000;中南大学化学化工学院,湖南,长沙,410083;中南大学化学化工学院,湖南,长沙,410083;湖南理工学院化学化工系,湖南,岳阳,414000 |
| 基金项目： | 国家自然科学基金 , 湖南省自然科学基金 |
| 摘 要： | 研究了布洛芬对映体在含有疏水性L-酒石酸酯的1,2-二氯乙烷溶液及甲醇水溶液两相中的萃取分配行为，考察了不同烷基链长的L-酒石酸酯、D-酒石酸酯以及L-酒石酸酯的浓度、有机溶剂的种类和溶解布洛芬的甲醇水溶液浓度对分配系数K和分离因子α的影响。实验表明，L-酒石酸酯与布洛芬Ⅱ对映体形成的复合物稳定性比与布洛芬Ⅰ对映体形成的复合物稳定性要大，而D-酒石酸酯的萃取性能则与此相反，它与布洛芬Ⅰ对映体形成的复合物稳定性比与布洛芬Ⅱ对映体形成的复合物稳定性要大。有机溶剂的萃取性能为醇＞1,2-二氯乙烷＞烷烃，随着溶解布洛芬的甲醇水溶液中甲醇浓度的增大，分配系数K和分离因子α均降低，当甲醇的浓度为10%时，可以得到最佳的K和α。随着L-酒石酸酯浓度的提高，分配系数K和分离因子α先增大后减小，当L-酒石酸酯的浓度约为0.2 mol·L-1时，K和α达到最大值；L-酒石酸酯的碳链长度对分配系数K和分离因子α也有很大的影响。 |
| 关 键 词： | 布洛芬 L-酒石酸酯 D-酒石酸酯 手性萃取 |
| 文章编号： | 0438-1157（2007）03-0679-06 |
| 收稿时间： | 2006-02-14 |
| 修稿时间： | 2006-02-142006-07-31 |
Separation of ibuprofen enantiomers by chiral extraction with hydrophobic tartaric esters |
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| YAN Jianhui,SHENG Ying,HUANG Kelong,TANG Kewen,YI Jianmin. Separation of ibuprofen enantiomers by chiral extraction with hydrophobic tartaric esters[J]. Journal of Chemical Industry and Engineering(China), 2007, 58(3): 679-684 | |
| Authors: | YAN Jianhui SHENG Ying HUANG Kelong TANG Kewen YI Jianmin |
| Affiliation: | 1 Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang 414000, Hunan, China ; 2 School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, Hunan, China |
| Abstract: | The distribution of ibuprofen enantiomers was examined in aqueous methanol solution and 1,2-dichloroethane organic solvent containing a chiral selector hydrophobic L-tartaric ester or D-tartaric ester.The influences of the length of alkyl chain of L-tartaric ester or D-tartaric ester, the concentration of L-tartaric ester,different organic solvents and the concentration of aqueous methanol solution on the partition coefficient(K) and separation factor(α) of ibuprofen, were investigated.L-tartaric ester formed more stable complex with Ⅱ-ibuprofen than with Ⅰ-ibuprofen.In contrast,D-tartaric ester formed more stable complex withⅠ-ibuprofen than with Ⅱ-ibuprofen.The extraction performance of organic solvents was different.For example, alcohols＞1,2-dichloroethane＞alkanes.K and αwere the highest when the concentration of aqueous methanol solution was 10%.With further increasing concentration of aqueous methanol solution,partition coefficient and separation factor decreased.With increasing concentration of L-tartaric ester, K and αincreased firstly,and then decreased.K and αwere the highest,when the concentration of L-tartaric ester was 0.2 mol·L-1.The length of alkyl chain of L-tartaric esters and D-tartaric esters also had a great influence on K and α. |
| Keywords: | ibuprofen L-tartaric esters D-tartaric esters chiral extraction |
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