| 桦木醇吡啶盐衍生物的合成及其生理活性研究 |
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| 引用本文： | 栾俊颖,池万福,韩荣弼.桦木醇吡啶盐衍生物的合成及其生理活性研究[J].延边大学理工学报,2014(2):117-120. |
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| 作者姓名： | 栾俊颖 池万福 韩荣弼 |
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| 作者单位： | 延边大学长白山生物资源与功能分子教育部重点实验室,吉林 延吉133002 |
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| 基金项目： | 国家自然科学基金资助项目（21362039）;吉林省科技发展计划项目（20130101025JC） |
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| 摘 要： | 以桦木醇为原料合成了4种桦木醇吡啶盐,运用1 H-NMR和IR确认了化合物的结构.用噻唑蓝(MTT)比色法对这4种化合物对肝星状细胞、人肺癌细胞和人肝癌细胞的抑制作用进行了活性分析,结果表明,化合物3、4a和4c对上述3种癌细胞有明显的抑制作用,并且对肝星状细胞的IC50值均明显低于桦木醇.
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| 关 键 词： | 桦木醇 吡啶盐衍生物 MTT法 抗癌活性 |
Synthesisand physiological activity research of betulin pyridinium salt derivatives |
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| Affiliation: | LUAN Junying, CHI Wanfu, HAN Rongb( Key Laboratory of Natural Resources of Changbai Mountain ＆ Functional Molecules (Yanbian University) , Ministry of Education, Yanji 133002, China ) |
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| Abstract: | Four betulin pyridinium salts were prepared from botulin.The structure of the products were identified by 1 H-NMR and IR.In order to study the effects of betulin pyridinium salts on inhibiting tumor cells,activity analysis of compounds 3and 4a-c on the HSC cell,A549cell and HepG 2was carried out by MTT assay.The results showed that compounds 3,4aand 4chad obvious inhibitory action on the HSC cell,A549cell and HepG2.On HepG2cells,IC50of compounds 3,4aand 4cwere significantly lower than IC50of betulin. |
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| Keywords: | betulin pyridine salt derivatives MTT assay anti-cancer activity |
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