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Nanohybrids with Magnetic and Persistent Luminescence Properties for Cell Labeling,Tracking, In Vivo Real‐Time Imaging,and Magnetic Vectorization
Authors:Eliott Teston  Thomas Maldiney  Iris Marangon  Jeanne Volatron  Yoann Lalatonne  Laurence Motte  Catherine Boisson‐Vidal  Gwennhael Autret  Olivier Clément  Daniel Scherman  Florence Gazeau  Cyrille Richard
Affiliation:1. Unité des Technologies Chimiques et Biologiques pour la Santé (UTCBS), UMR 8258 CNRS, U 1022 Inserm, Faculté de Pharmacie de Paris Université Paris DescartesSorbonne Paris Cité, Paris, cedex, France;2. Laboratoire Matière et Systèmes Complexes (MSC), UMR 7057 CNRS, Université Paris Diderot, Paris, cedex, France;3. Inserm, U1148, Laboratory for Vascular Translational Science, Université Paris 13, Bobigny, France;4. Unité mixte de recherche 1140 – Thérapeutiques innovantes en hémostase, Faculté de Pharmacie de Paris, cedex, France;5. Laboratoire de Recherche en Imagerie, EA 4062, Inserm U 970 ou 494 Equipe 2, PARCC, Université Paris Descartes, H?pital Européen George Pompidou, Paris, France
Abstract:
Once injected into a living organism, cells diffuse or migrate around the initial injection point and become impossible to be visualized and tracked in vivo. The present work concerns the development of a new technique for therapeutic cell labeling and subsequent in vivo visualization and magnetic retention. It is hypothesized and subsequently demonstrated that nanohybrids made of persistent luminescence nanoparticles and ultrasmall superparamagnetic iron oxide nanoparticles incorporated into a silica matrix can be used as an effective nanoplatform to label therapeutic cells in a nontoxic way in order to dynamically track them in real‐time in vitro and in living mice. As a proof‐of‐concept, it is shown that once injected, these labeled cells can be visualized and attracted in vivo using a magnet. This first step suggests that these nanohybrids represent efficient multifunctional nanoprobes for further imaging guided cell therapies development.
Keywords:cell labeling  hybrids  imaging  magnetic vectorization  nanoparticles
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