| 超临界抗溶剂法制备维生素D3脂质体前体及其表征（英文） |
| |
| 引用本文： | 夏菲,金鹤阳,赵亚平,郭新秋.超临界抗溶剂法制备维生素D3脂质体前体及其表征（英文）[J].中国化学工程学报,2011,19(6):1039-1046. |
| |
| 作者姓名： | 夏菲 金鹤阳 赵亚平 郭新秋 |
| |
| 作者单位： | 1. College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;2. Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China |
| |
| 基金项目： | Supported by the National High Technology Research and Development Program of China (2007AA10Z350); the National Natural Science Foundation of China (20976103) |
| |
| 摘 要： | Vitamin D3 (VD3) proliposomes (VDP), consisted of hydrogenated phosphatidycholine (HPC) and VD3, were prepared using supercritical anti-solvent technology (SAS). The effects of operation conditions (temperature, pressure and components) on the VD3 loading in VDP were studied. At the optimum conditions of pressure of 8.0 MPa, temperature of 45 ℃, and the mass ratio of 15.0% between VD3 and HPC, the VD3 loading reached 12.89%. VD3 liposomes (VDL) were obtained by hydrating VDP and the entrapment efficiency of VD3 in VDL reached 98.5%. The morphology and structure of VDP and VDL were characterized by SEM (scanning electron micro-scope), TEM (transmission electron microscope) and XRD (X-ray diffractometer). The structure of VD3 nanoparti-cles in HPC matrix was formed. The size of VDL with an average diameter of about 1μm was determined by dynamic light scattering instrument (DLS). The results indicated that VDP can be made by SAS and VDL with high entrapment efficiency can be formed easily via the hydration of VDP.
|
| 关 键 词： | 维生素D3 超临界抗溶剂 脂质体 技术 透射电子显微镜 扫描电子显微镜 特征 前体 |
| 收稿时间： | 2010-12-07 |
Supercritical Antisolvent-based Technology for Preparation of Vitamin D_3 Proliposome and Its Characteristics |
| |
| XIA Fei,JIN Heyang,ZHAO Yaping, GUO Xinqiu College of Chemistry , Chemical Engineering,Shanghai Jiao Tong University,Shanghai ,China Instrumental Analysis Center,China.Supercritical Antisolvent-based Technology for Preparation of Vitamin D_3 Proliposome and Its Characteristics[J].Chinese Journal of Chemical Engineering,2011,19(6):1039-1046. |
| |
| Authors: | XIA Fei JIN Heyang ZHAO Yaping GUO Xinqiu College of Chemistry Chemical Engineering Shanghai Jiao Tong University Shanghai China Instrumental Analysis Center China |
| |
| Affiliation: | 1. College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;2. Instrumental Analysis Center, Shanghai Jiao Tong University, Shanghai 200240, China |
| |
| Abstract: | Vitamin D3 (VD3) proliposomes (VDP), consisted of hydrogenated phosphatidycholine (HPC) and VD3, were prepared using supercritical anti-solvent technology (SAS). The effects of operation conditions (temperature, pressure and components) on the VD3 loading in VDP were studied. At the optimum conditions of pressure of 8.0 MPa, temperature of 45℃, and the mass ratio of 15.0% between VD3 and HPC, the VD3 loading reached 12.89%. VD3 liposomes (VDL) were obtained by hydrating VDP and the entrapment efficiency of VD3 in VDL reached 98.5%. The morphology and structure of VDP and VDL were characterized by SEM (scanning electron microscope), TEM (transmission electron microscope) and XRD (X-ray diffractometer). The structure of VD3 nanoparticles in HPC matrix was formed. The size of VDL with an average diameter of about 1μm was determined by dynamic light scattering instrument (DLS). The results indicated that VDP can be made by SAS and VDL with high entrapment efficiency can be formed easily via the hydration of VDP. |
| |
| Keywords: | hydrogenated phosphatidycholine liposome encapsulation supercritical anti-solvent |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国化学工程学报》浏览原始摘要信息 |
|
点击此处可从《中国化学工程学报》下载全文 |
|
