Specific Maltose Derivatives Modulate the Swarming Motility of Nonswarming Mutant and Inhibit Bacterial Adhesion and Biofilm Formation by Pseudomonas aeruginosa |
| |
| Authors: | Gauri S. Shetye Nischal Singh Changqing Jia Chan D. K. Nguyen Dr. Guirong Wang Dr. Yan‐Yeung Luk |
| |
| Affiliation: | 1. Department of Chemistry, Syracuse University, Syracuse, New York 13244 (USA);2. Department of Surgery, SUNY Upstate Medical University, Syracuse, New York 13210 (USA) |
| |
| Abstract: | We have demonstrated that specific synthetic maltose derivatives activate the swarming motility of a Pseudomonas aeruginosa nonswarming mutant (rhlA) at low concentration, but inhibit it at high concentration. Although these molecules are not microbicidal, active maltose derivatives with bulky hydrocarbon groups inhibited bacterial adhesion, and exhibited biofilm inhibition and dispersion (IC50 ～20 μM and DC50 ～30 μM , respectively). Because the swarming motility of the rhlA mutant is abolished by the lack natural rhamnolipids, the swarming activation suggests that maltose derivatives are analogues of rhamnolipids. Together, these results suggest a new approach of controlling multiple bacterial activities (bacterial adhesion, biofilm formation, and swarming motility) by a set of disaccharide‐based molecules. |
| |
| Keywords: | biofilm inhibition disaccharide hydrocarbons inhibitors Pseudomonas aeruginosa swarming motility |
|
|
