Anticancer Potency Studies of Coordination Driven Self‐Assembled Arene–Ru‐Based Metalla‐Bowls |
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| Authors: | Dr Anurag Mishra Yong Joon Jeong Jae‐Ho Jo Prof Se Chan Kang Prof Myoung Soo Lah Prof Ki‐Whan Chi |
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| Affiliation: | 1. Department of Chemistry, University of Ulsan, Ulsan 680‐749 (Republic of Korea);2. Department of Life Science, College of Bionano Technology, Gachon University, Seongnam 461‐701 (Republic of Korea);3. Interdisciplinary School of Green Energy, Ulsan National Institute of Science & Technology, Ulsan 689‐798 (Republic of Korea) |
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| Abstract: | New tetranuclear cationic metalla‐bowls 5 – 7 with the general formula Ru4(p‐cymene)4(N∩N)2(OO∩OO)2]4+ (N∩N=2,6‐bis(N‐(4‐pyridyl carbamoyl)pyridine, OO∩OO=2,5‐dihydroxy‐1,4‐benzoquinonato ( 5 ), OO∩OO=5,8‐dioxydo‐1,4‐naphthaquinonato ( 6 ), OO∩OO=hoxonato ( 7 )) were prepared by the reaction of the respective dinuclear ruthenium complexes 2 – 4 with a bispyridine amide donor ligand 1 in methanol in the presence of AgO3SCF3.These new molecular metalla‐bowls were fully characterized by analytical techniques including elemental analysis as well as 1H and 13C NMR and HR‐ESI‐MS spectroscopy. The structure of metalla‐bowl 6 was determined from X‐ray crystal diffraction data. A UV/visible study was also carried out for the entire suite of new complexes. As with recent studies of similar arene–Ru complexes, the inhibition of cell growth by metalla‐bowls was established against SK‐hep‐1 (liver cancer), AGS (gastric cancer), and HCT‐15 (colorectal cancer) human cancer cell lines. Inhibition of cell growth by 6 was found to be considerably stronger against all cancer cell lines than the anticancer drugs, doxorubicin and cisplatin. In particular, in colorectal cancer cells, expression of the cancer suppressor genes APC and p53 was increased following exposure to 6 . |
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| Keywords: | anticancer activity arene– Ru biological activity cancer coordination‐driven self‐assembly metalla‐bowls |
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