Vitamin E acetate addition to poly(d,l)lactic acid modifies its mechanical behavior without affecting biocompatibility |
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| Authors: | Pamela Pittarella Diego Antonioli Manuela Rizzi Michele Laus Filippo Renò |
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| Affiliation: | 1. Innovative Research Laboratory for Wound Healing, Health Sciences Department, University of Eastern Piedmont “A. Avogadro,” Via Solaroli 17, Novara, Italy;2. Department of Sciences and Technological Innovation, University of Eastern Piedmont “A. Avogadro,” V. Teresa Michel 11, Alessandria, Italy |
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| Abstract: | Mechanical properties of poly(d,l )lactic acid films enriched with Vitamin E and Vitamin E Acetate (5–40% w/w) were investigated. The addition of both formulations resulted in increased polymer Young's modulus and tensile strength. Human foreskin fibroblasts and murine pre‐osteoblasts were used to assess the biocompatibility of polymers. Pre‐osteoblasts adhesion and proliferation were strongly decreased by Vitamin E, whereas Vitamin E Acetate did not alter cell proliferation. Collagen deposition was lower onto Vitamin E blended polymers than onto native and Vitamin E Acetate blended ones. Fibroblasts adhesion and proliferation were increased by both Vitamin E and Vitamin E Acetate addition. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2014 , 131, 39970. |
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| Keywords: | biocompatibility biomaterials blends films mechanical properties |
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