Temperature‐responsiveness and sustained delivery properties of macroporous PEG‐co‐PNIPAAm‐co‐PCL hydrogels |
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| Authors: | Zhao‐Xia Li Man‐Geng Lu Kun Wu Yun‐Fei Zhang Lei Miao Yin‐Wen Li Hui‐Long Guo Jian Zheng |
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| Affiliation: | 1. Key Laboratory of Cellulose and Lignocellulosics Chemistry, Guangzhou Institute of Chemistry, University of Chinese Academy of Sciences, Guangzhou, People's Republic of China;2. University of Chinese Academy of Sciences, Beijing, People's Republic of China |
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| Abstract: | A series of novel thermosensitive macroporous poly (ethylene glycol) (PEG)‐co‐poly(N‐isopropylacrylamide) (PNIPAAm)‐co‐poly (ε‐caprolactone) (PCL) hydrogels were synthesized via in situ free radical polymerization. Poly(ethylene glycol diacrylate) (PEGDAc) and poly(ε‐caprolactone diacrylate) (PCLDAc) were prepared as macrocrosslinkers. All compounds were investigated by Nuclear Magnetic Resonance (NMR) and Fourier transform‐infrared spectroscopy (FT‐IR). Differential Scanning Calorimetry (DSC) results showed the lower critical solution temperatures (LCSTs) of the gels were at around 31°C. The macroporous gels not only had considerable swelling ratios, but also exhibited rapid swelling kinetics and response sensitivity. Above mentioned hydrogels showed a remarkable oscillatory swelling–deswelling transition, making them have potential application in long‐term drug delivery. POLYM. ENG. SCI., 55:223–230, 2015. © 2014 Society of Plastics Engineers |
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