Effect of the cultivation mode on red pigments production from Monascus ruber |
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| Authors: | Hassan Hajjaj Gerard Goma Jean M François |
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| Affiliation: | 1. Laboratoire de Biotechnologie Végétale et Biologie Moléculaire, Faculté des Sciences, Univ. Moulay Ismail, Meknès, Morocco;2. Université de Toulouse;3. INSA, UPS, INP, F‐31077 Toulouse, France;4. INRA, UMR792 Ingénierie des Systèmes Biologiques et des Procédés, F‐31077 Toulouse, France;5. CNRS, UMR5504, F‐31077 Toulouse, France |
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| Abstract: | In submerged cultures performed in chemically defined fermentation medium containing glucose and glutamate, the growth and production of water‐soluble red pigments and citrinin by the filamentous fungus Monascus ruber were studied under various carbon/nitrogen (C/N) ratios. The specific production of the red pigments was optimal at a glucose/glutamate ratio of about 10 and then steadily decreased at higher C/N ratio. In contrast, the production of the mycotoxin increased with increased C/N with an optimum in the range of 30–45. In a fed‐batch mode, it was also found that the production of pigments was not favoured in fed‐batch mode by feeding the medium with glucose while keeping the C/N ratio lower than 10. This low production likely resulted from concurrent high accumulation of L‐malic acid that was reported to inhibit this production. In contrast, this mode of cultivation was rather favourable for the production of the mycotoxin. |
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| Keywords: | Citrinin and red pigments fermentation
Monascus
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