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| 固体脂质微颗粒表面稳定剂的分布状况对其稳定性的影响：介观模拟与实验 | |
| 引用本文： | 章莉娟,龙春霞,钱宇,刘磊. 固体脂质微颗粒表面稳定剂的分布状况对其稳定性的影响：介观模拟与实验[J]. 化工学报, 2007, 58(1): 181-189 |
| 作者姓名： | 章莉娟 龙春霞 钱宇 刘磊 |
| 作者单位： | 华南理工大学化工学院 |
| 基金项目： | 国家自然科学基金 , 国家自然科学基金 , 广东省自然科学基金 |
| 摘 要： | 用耗散粒子动力学（DPD）方法研究了稳定剂在负载布洛芬的固体脂质微颗粒（solid lipid microparticles, SLM）表面的分布状况。模拟结果表明：以卵磷脂为稳定剂，当布洛芬的摩尔分数为1%和2%时，卵磷脂较好地包覆在颗粒的表面；而当布洛芬的摩尔分数增大到3%和5%时，卵磷脂不能覆盖在布洛芬分子密集的部位。以poloxamer 407和PVA为稳定剂，随着布洛芬摩尔分数由1%增大到5%，稳定剂都能很好地包覆在颗粒的表面。实验现象较好地吻合了模拟结果。采用DPD模拟方法，可以加深了解多相复杂载药体系的微观结构并对实验现象进行分析，为SLM稳定剂的筛选提供理论指导。 |
| 关 键 词： | 耗散粒子动力学 介观模拟 稳定剂 固体脂质微颗粒 |
| 文章编号： | 0438-1157（2007）01-0181-09 |
| 收稿时间： | 2006-03-03 |
| 修稿时间： | 2006-03-032006-07-25 |
Stabilizer distribution on surface of solid lipid microparticles and SLM stability: mesoscale simulation and experiments |
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| ZHANG Lijuan,LONG Chunxia,QIAN Yu,LIU Lei. Stabilizer distribution on surface of solid lipid microparticles and SLM stability: mesoscale simulation and experiments[J]. Journal of Chemical Industry and Engineering(China), 2007, 58(1): 181-189 | |
| Authors: | ZHANG Lijuan LONG Chunxia QIAN Yu LIU Lei |
| Affiliation: | School of Chemical Engineering, South China University of Technology, Guangzhou 510640, Guangdong, China |
| Abstract: | Dissipative particle dynamics(DPD) simulation was used to model the distribution of stabilizers(lecithin,poroxamer and PVA)on the surface of ibuprofen-loaded solid lipid microparticles(SLM).It was shown from DPD simulation results that lecithin totally enwrapped the surface of SLM when the molar fraction of ibuprofen was 1% and 2%.However,when the molar fraction of ibuprofen was increased to 3% and 5%,lecithin could not cover the place with a higher concentration of ibuprofen molecules.Poloxamer 407 and PVA totally enwrapped the surface of SLM when the molar fraction of ibuprofen was increased from 1% to 5%.The experimental results could be interpreted with the simulation results.DPD simulation provides an insight into the microstructure of a drug carrier and helps to analyze the experimental results,which is helpful in stabilizer selection for SLM. |
| Keywords: | dissipative particle dynamics mesoscale simulation stabilizer solid lipid microparticles |
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