Design of intelligent chitosan/heparin hollow microcapsules for drug delivery |
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| Authors: | Lili Sun Xin Xiong Qiaogen Zou Pingkai Ouyang Claus Burkhardt Rumen Krastev |
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| Affiliation: | 1. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China;2. NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany;3. School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China;4. Faculty of Applied Chemistry, Reutlingen University, Reutlingen, Germany |
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| Abstract: | In this study, a novel strategy has been developed for the assembly of polyelectrolyte multilayer (PEM) on CaCO3 templates in acidic pH solutions, where consecutive polyelectrolyte layers (heparin/poly(allylamine hydrochloride) or heparin/chitosan) were deposited on PEM hollow microcapsules established previously on CaCO3 templates. The PEM build‐up, hollow capsule characterization and successful encapsulation of fluorescein 5(6)‐isothiocyanate (FITC)‐Dextran by coprecipitation with CaCO3 are demonstrated. Improvement by the removal of CaCO3 core was achieved while the depositions. In the course of the release profile, high retardation for encapsulated FITC‐Dextran was observed. The combined shell capsules system is a significant trait that has potential use in tailoring functional layer‐by‐layer capsules as intelligent drug delivery vehicles where the preliminary in vitro tests showed the responsiveness on the enzymes. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134, 44425. |
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| Keywords: | biomedical applications drug delivery systems polyelectrolytes |
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