Flurbiprofen axetil loaded coaxial electrospun poly(vinyl pyrrolidone)–nanopoly(lactic‐co‐glycolic acid) core–shell composite nanofibers: Preparation,characterization, and anti‐adhesion activity |
| |
| Authors: | Tonghe Zhu Sihao Chen Wenyao Li Jianzhong Lou Jihu Wang |
| |
| Affiliation: | 1. School of Fashion Design, Shanghai University of Engineering Science, Shanghai, People's Republic of China;2. Multidisciplinary Center for Advanced Materials, Shanghai University of Engineering Science, Shanghai, People's Republic of China;3. College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai, People's Republic of China;4. School of Materials Engineering, Shanghai University of Engineering Science, Shanghai, People's Republic of China;5. Department of Chemical Engineering and Biomedical Engineering, North Carolina A&T State University, Greensboro, North Carolina |
| |
| Abstract: | Flurbiprofen axetil (FA)‐loaded coaxial electrospun poly(vinyl pyrrolidone) (PVP)–nanopoly(lactic‐co‐glycolic acid) core–shell composite nanofibers were successfully fabricated by a facile coaxial electrospinning, and an electrospun drug‐loaded system was formed for anti‐adhesion applications. The FA, which is a kind of lipid microsphere nonsteroidal anti‐inflammatory drug, was shown to be successfully adsorbed in the PVP, and the formed poly(lactic‐co‐glycolic acid) (PLGA)/PVP/FA composite nanofibers exhibited a uniform and smooth morphology. The cell viability assay and cell morphology observation revealed that the formed PLGA/PVP/FA composite nanofibers were cytocompatible. Importantly, the loaded FA within the PLGA/PVP coaxial nanofibers showed a sustained‐release profile and anti‐adhesion activity to inhibit the growth of the IEC‐6 and NIH3T3 model cells. With the significantly reduced burst‐release profile, good cytocompatibility, and anti‐adhesion activity, the developed PLGA/PVP/FA composite nanofibers were proposed to be a promising material in the fields of tissue engineering and pharmaceutical science. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 41982. |
| |
| Keywords: | biomaterials electrospinning fibers |
|
|
