Controllable Generation of Nitric Oxide by Near‐Infrared‐Sensitized Upconversion Nanoparticles for Tumor Therapy |
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| Authors: | Xiao Zhang Gan Tian Wenyan Yin Liming Wang Xiaopeng Zheng Liang Yan Jinxia Li Haoran Su Chunying Chen Zhanjun Gu Yuliang Zhao |
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| Affiliation: | 1. Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics and National Center for Nanosciences and Technology, Chinese Academy of Sciences, Beijing, P.R. China;2. College of Chemistry, Sichuan University, Chengdu, P. R. China;3. College of Materials Science and Opto‐electronic Technology, University of Chinese Academy of Sciences, Beijing, P. R. China |
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| Abstract: | NaYbF4:Tm@NaYF4:Yb/Er upconversion nanoparticles are synthesized and then integrated with light‐sensitive nitric oxide (NO) donors (Roussin's black salt) to construct a novel near‐infrared (NIR)‐triggered on‐demand NO delivery platform. This nanocompound can absorb 980 nm NIR photons, convert them into higher energy photons and then transfer the energy to the NO donors, resulting in an efficient release of NO. By manipulating the output power of the 980‐nm NIR light, NO‐concentration‐dependent biological effects for cancer therapy can be fine‐tuned, which is investigated and confirmed in vitro. High concentrations of NO can directly kill cancer cells and low concentrations of NO can act as a potent P‐glycoprotein (P‐gp) modulator to overcome multi‐drug resistance (MDR) if combined with chemotherapy. |
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| Keywords: | upconversion nanoparticles nitric oxide energy transfer dose‐dependent biological effect multi‐drug resistance reversal |
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