| 代谢工程改造微生物固定二氧化碳研究进展 |
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| 引用本文： | 陶雨萱,郭亮,高聪,宋伟,陈修来.代谢工程改造微生物固定二氧化碳研究进展[J].化工进展,2023,42(1):40-52. |
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| 作者姓名： | 陶雨萱 郭亮 高聪 宋伟 陈修来 |
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| 作者单位： | 1.江南大学食品科学与技术国家重点实验室，江苏 无锡 214122;2.江南大学生命科学与健康工程学院，江苏 无锡 214122 |
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| 基金项目： | 国家重点研发计划(2021YFC2103500);国家自然科学基金(22122806);江苏省自然科学基金(BK20211529) |
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| 摘 要： | 微生物固定CO2是实现CO2资源化利用的有效策略之一，为固碳减排、节能生产与绿色合成提供了借鉴。然而，微生物在固定CO2过程中存在底物利用效率低、能量需求量大、路径难优化等问题。为了解决这些问题，本文总结了6种天然CO2固定途径与5种人工CO2固定途径，并从自养微生物、异养微生物和人工微生物三个方面系统分析了代谢工程改造微生物固定CO2合成化学品的最新进展。在自养微生物固定CO2方面，采用的策略主要包括提高CO2固定途径效率、开发能量捕集系统与调节碳代谢流分布；在异养微生物固定CO2方面，常用的方法主要有强化羧化途径、重构CO2固定途径与优化能量供给；在人工微生物固定CO2方面，主要的研究思路是设计人工CO2固定途径与构建人工CO2固定微生物。最后，从CO2固定的关键酶、途径和微生物...
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| 关 键 词： | 微生物 代谢工程 二氧化碳固定 固碳减排 |
| 收稿时间： | 2022-08-22 |
Progress in metabolic engineering of microorganisms for CO2 fixation |
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| TAO Yuxuan,GUO Liang,GAO Cong,SONG Wei,CHEN Xiulai.Progress in metabolic engineering of microorganisms for CO2 fixation[J].Chemical Industry and Engineering Progress,2023,42(1):40-52. |
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| Authors: | TAO Yuxuan GUO Liang GAO Cong SONG Wei CHEN Xiulai |
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| Affiliation: | 1.State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China
2.School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, Jiangsu, China |
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| Abstract: | Microbial CO2 fixation is one of the effective strategies to realize CO2 resource utilization, which provides a reference for carbon abatement, energy-saving production and green synthesis. However, there are problems in microbial CO2 fixation process, such as insufficient CO2 utilization rate, high energy demand, and difficult pathway optimization. In order to solve these problems, this paper summarizes six natural CO2 fixation pathways and five artificial CO2 fixation pathways, and systematically analyzes the latest progress of metabolic engineering of microorganisms for CO2 fixation from three aspects: autotrophic microorganisms, heterotrophic microorganisms and artificial microorganisms. For CO2 fixation by autotrophic microorganisms, the main strategies include improving the efficiency of CO2 fixation pathways, developing energy capture systems, and regulating the distribution of carbon metabolism. For CO2 fixation by heterotrophic microorganisms, the main methods include strengthening the carboxylation pathway, remodeling the CO2 fixation pathway, and optimizing the energy supply. For CO2 fixation by artificial microorganisms, the main research ideas include the design of artificial CO2 fixation pathways and the construction of artificial CO2 fixation microorganisms. Finally, we further prospect the development direction of improving CO2 fixation efficiency by engineering key enzymes, pathways and microorganisms. |
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| Keywords: | microorganisms metabolic engineering CO2 fixation carbon abatement |
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