| 利伐沙班的定量检测:拉曼光谱法与远红外吸收光谱法 |
| |
| 引用本文： | 吕嘉明.利伐沙班的定量检测:拉曼光谱法与远红外吸收光谱法[J].红外与激光工程,2021,50(2):20210038-1-20210038-5. |
| |
| 作者姓名： | 吕嘉明 |
| |
| 作者单位： | 北京中矿业恒科技有限公司，北京 100083 |
| |
| 摘 要： | 利伐沙班是一种新型口服抗凝药,它具有疗效确切、安全性好、使用方便等优点,所以经常用于静脉血栓栓塞性疾病的预防与治疗,以及非瓣膜性房颤的卒中预防。由于利伐沙班在患者体内的浓度会影响其对凝血因子Xa的抑制作用,这导致患者的临床反应有个体差异,影响最终治疗效果。为了更加合理地使用利伐沙班,临床上需要监测人体血液或尿液中利伐沙班的浓度。针对该临床需求,文中基于远红外指纹谱和拉曼特征谱在物质有效识别和定量分析的优势,采用傅里叶变换红外光谱仪和激光共聚焦拉曼光谱系统,针对液体状态下利伐沙班进行识别并定量检测。文中先通过傅里叶变换红外光谱仪检测利伐沙班的远红外吸收谱随其浓度发生的变化,再通过激光共聚焦拉曼光谱系统检测了利伐沙班的拉曼光谱随其浓度发生的变化,最后比较了远红外光谱法与拉曼法的准确率。经过比较,远红外检测的精度比拉曼光谱检测的精度提升2倍。这些结果对临床医学中利伐沙班的使用具有重要意义。
|
| 关 键 词： | 利伐沙班 远红外吸收光谱 拉曼光谱 定量检测 |
| 收稿时间： | 2021-01-05 |
Quantitative detection of rivaroxaban based on far-IR absorbance spectroscopy and Raman spectroscopy |
| |
| Lv Jiaming.Quantitative detection of rivaroxaban based on far-IR absorbance spectroscopy and Raman spectroscopy[J].Infrared and Laser Engineering,2021,50(2):20210038-1-20210038-5. |
| |
| Authors: | Lv Jiaming |
| |
| Affiliation: | Beijing ZKYH Technology Co., Ltd, Beijing 100083, China |
| |
| Abstract: | Rivaroxaban is a new type of oral anticoagulant, which has the advantages of definite curative effect, good safety and convenient use, so it is often used in the prevention and treatment of venous thromboembolic diseases and stroke prevention of non valvular atrial fibrillation. Due to the concentration of rivaroxaban in patients, it will affect the inhibition of coagulation factor Xa, which leads to individual differences in the clinical response of patients and affects the final treatment effect. In order to use rivaroxaban more reasonably, it is necessary to monitor the concentration of rivaroxaban in human blood or urine. For the clinical needs, based on the advantages of far-infrared fingerprint spectrum and Raman characteristic spectrum in effective identification and quantitative analysis of substances, Fourier transform infrared spectrometer and laser confocal Raman spectroscopy system were used to identify and quantitatively detect rivaroxaban in liquid state. In this paper, the change of far-infrared absorption spectrum of rivaroxaban with its concentration was detected by Fourier transform infrared spectrometer, and then the change of Raman spectrum of rivaroxaban with its concentration was detected by laser confocal Raman spectroscopy system. Finally, the accuracy of far-infrared spectroscopy method and Raman method was compared. After comparison, it is proved that the accuracy of far-infrared detection is 2 times higher than that of Raman spectrum detection. These results are of great significance for the use of rivaroxaban in clinical medicine. |
| |
| Keywords: | rivaroxaban far-IR absorbance spectroscopy Raman spectroscopy quantitative detection |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《红外与激光工程》浏览原始摘要信息 |
|
点击此处可从《红外与激光工程》下载全文 |
|
