Thermo‐ and glucose‐sensitive microgels with improved salt tolerance for controlled insulin release in a physiological environment |
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| Authors: | Shiling Gu Liu Yang Shirui Li Junjiao Yang Bo Zhang Jing Yang |
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| Affiliation: | 1. State Key Laboratory of Chemical Resource, Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China;2. Department of Endocrinology, China‐Japan Friendship Hospital, Beijing, China;3. College of Science, Beijing University of Chemical Technology, Beijing, China |
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| Abstract: | The response to temperature and glucose, high salt tolerance and self‐regulated drug delivery are simultaneously probable by applying a multifunctional microgel in a rational design by a colloid chemistry method. Such smart microgels were fabricated with thermoresponsive N‐isopropylacrylamide, glucose‐sensitive (2‐phenylboronic esters‐1,3‐dioxane‐5‐ethyl)methyl acrylate (PBDEMA) and water‐soluble crosslinker poly(ethylene glycol) diacrylate through a precipitation emulsion method. These colloidal nanoparticles exhibited PBDEMA‐composition‐dependent responsive behavior with changing temperature and ionic strength. Amongst them, the microgel with 20.7 mol% PBDEMA with a narrow size distribution is suitable for diabetes treatment because it can adapt to the surrounding medium of different glucose concentrations over a clinically relevant range (0–2.0 mg mL?1), control the release of preloaded insulin and is highly stable under normal physiological conditions. Preliminary experiments suggest these highly stable microgels have the potential to be used for self‐regulated therapy and monitoring the response to treatment. © 2018 Society of Chemical Industry |
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| Keywords: | microgel glucose‐responsive insulin delivery thermoresponsive self‐regulated release |
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