| 5-硝基苯并咪唑酮在铜网电极上还原制备5-氨基苯并咪唑酮 |
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| 引用本文： | 钮东方,王海洋,俞秋雁,张新胜.5-硝基苯并咪唑酮在铜网电极上还原制备5-氨基苯并咪唑酮[J].化工学报,2014,65(1):292-297. |
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| 作者姓名： | 钮东方 王海洋 俞秋雁 张新胜 |
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| 作者单位： | 1.化学工程联合国家重点实验室(华东理工大学), 上海 200237;2.浙江九洲药物科技有限公司, 浙江 杭州 310051 |
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| 摘 要： | 研究了以5-硝基苯并咪唑酮为原料在铜网电极上还原制备5-氨基苯并咪唑酮的反应。循环伏安结果表明5-硝基苯并咪唑酮的电化学还原是一受扩散控制的不可逆反应；探讨了电极材料、电流密度、温度和通电量对产物产率的影响，在最优条件下5-氨基苯并咪唑酮的产率可达93%；电解液连续套用10次后，5-氨基苯并咪唑酮产率仍然可以维持在93%左右，与新鲜电解液效果相当。
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| 关 键 词： | 铜网电极 电化学还原 5-硝基苯并咪唑酮 5-氨基苯并咪唑酮 电解液循环 |
| 收稿时间： | 2013-06-20 |
| 修稿时间： | 2013-08-31 |
Electro-reductive conversion of 5-nitrobenzimidazolone to 5-aminobenzimidazolone on copper mesh cathode |
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| NIU Dongfang,WANG Haiyang,YU Qiuyan,ZHANG Xinsheng.Electro-reductive conversion of 5-nitrobenzimidazolone to 5-aminobenzimidazolone on copper mesh cathode[J].Journal of Chemical Industry and Engineering(China),2014,65(1):292-297. |
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| Authors: | NIU Dongfang WANG Haiyang YU Qiuyan ZHANG Xinsheng |
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| Affiliation: | 1.State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China;2.Zhejiang Jiuzhou Pharmaceutical. Co., Ltd., Hangzhou 310051, Zhejiang, China |
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| Abstract: | 5-aminobenzimidazolone was prepared by electro-reduction of 5-nitrobenzimidazolone on copper mesh cathode. The electrochemical behavior was studied on Cu micro-electrode by cyclic voltammetry, and the result indicated that the electrochemical reduction of 5-nitrobenzimidazolone was an irreversible reaction controlled by diffusion. Influence of some key factors (such as nature of cathode material, current density, temperature and passed charge) on this reaction was investigated. Under the optimized condition, the yield of 5-aminobenzimidazolone reached 93%. The yield of 5-aminobenzimidazolone could still be maintained at about 93% after the catholyte was continuously recycled 10 times, corresponding to the effect of fresh catholyte. |
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| Keywords: | copper mesh electrode electro-reduction 5-nitrobenzimidazolone 5-aminobenzimidazolone recycle of catholyte |
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