| 乌索酸的生产工艺 |
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| 引用本文： | 李开泉,陈武,李翔一.乌索酸的生产工艺[J].化工学报,2006,57(2):380-381. |
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| 作者姓名： | 李开泉 陈武 李翔一 |
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| 作者单位： | 宜春学院生物工程研究所 |
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| 基金项目： | supported by the National High Technology Development Program of China （2002AA2Z3217）. |
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| 摘 要： | Production of ursolic acid, the anti-hepatitis effective composition from natural plant, Sambucus chinensis Lindl. was carried out and the scale-up preparation technology was studied. Extraction of the herb Sambucus chinensis Lindl. was extracted in reflux with 7 volume times of refluxing ethanol at 80℃ for 1 h for two times. The extract was purified with a seh-made specific impurity remover ＂YCXY-1＂ to yield ursolic acid of high purity. A new ＂Extraction/Gelation＂ technology for the production of ursolic acid was developed. The specific impurity remover ＂YCXY-1＂ showed high effectiveness in purification. The purity of the mass-produced ursolie acid was up to 99.8%. The chemical structure of the product was confirmed by the physicochemical constants and spectroscopic identification. The production of high-purity ursolic acid was optimized with natural plant as raw material and with only ethanol as extracting solvent. The difficulties such as isolation and impurity removal were addressed effectively. The novel technology is reasonable, convenient, practical, low-cost, high-yield, suitable for mass production.
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| 关 键 词： | 乌索酸 生产工艺 抗肝炎 中药 提取 分离 |
| 文章编号： | 0438-1157（2006）02-0380-02 |
| 收稿时间： | 2005-07-06 |
| 修稿时间： | 2005-07-06 |
Production process for ursolic acid |
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| LI Kaiquan,CHEN Wu,LI Xiangyi.Production process for ursolic acid[J].Journal of Chemical Industry and Engineering(China),2006,57(2):380-381. |
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| Authors: | LI Kaiquan CHEN Wu LI Xiangyi |
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| Abstract: | Production of ursolic acid, the anti-hepatitis effective composition from natural plant,Sambucus chinensis Lindl.was carried out and the scale-up preparation technology was studied.Extraction of the herb Sambucus chinensis Lindl.was extracted in reflux with 7 volume times of refluxing ethanol at 80℃ for 1 h for two times.The extract was purified with a selt-made specific impurity remover "YCXY-1" to yield ursolic acid of high purity.A new "Extraction/Gelation" technology for the production of ursolic acid was developed. The specific impurity remover "YCXY-1" showed high effectiveness in purification. The purity of the mass-produced ursolic acid was up to 99.8%. The chemical structure of the product was confirmed by the physicochemical constants and spectroscopic identification. The production of high-purity ursolic acid was optimized with natural plant as raw material and with only ethanol as extracting solvent. The difficulties such as isolation and impurity removal were addressed effectively. The novel technology is reasonable, convenient, practical, low-cost, high-yield, suitable for mass production. |
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| Keywords: | Sambucus chinensis Lindl ursolic acid extraction and separation production process |
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