| 缓释材料用量对水溶性药物骨架片释放度的影响 |
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| 引用本文： | 高迎春,张亮,卞正中.缓释材料用量对水溶性药物骨架片释放度的影响[J].化工学报,2005,56(10):2024-2028. |
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| 作者姓名： | 高迎春 张亮 卞正中 |
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| 作者单位： | 第四军医大学，陕西 西安 710032;西安交通大学生命科学与技术学院，陕西 西安 710049 |
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| 摘 要： | 水溶性药物卡托普利（Captopril，Cap）是第一代血管紧张素转换酶抑制剂，是治疗高血压的首选药物之一．常用剂型为糖衣片或普通片，由于其生物半衰期短，需要Ft服三次，且峰谷浓度差别较大，这可能是引起肺淤血、眩晕、头疼、肠胃道紊乱等不良反应的原因，有必要将其制为缓释剂型．国外已有Cap缓释胶囊上市，由于水溶性药物本身溶出很快，其释放较难被阻滞，国内尚无Cap的缓释品种上市．本实验参考国内外Cap缓释制剂的处方和制备工艺，筛选研制了Cap缓释骨架片．
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| 关 键 词： | 卡托普利 混合骨架片 体外释放度 蜡质888 |
| 文章编号： | 0438-1157（2005）10-2024-05 |
| 收稿时间： | 11 2 2004 12:00AM |
| 修稿时间： | 2004-11-022005-01-11 |
Effects of matrix material content on soluble drug release from matrix |
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| GAO Yingchun,ZHANG Liang,BIAN Zhengzhong.Effects of matrix material content on soluble drug release from matrix[J].Journal of Chemical Industry and Engineering(China),2005,56(10):2024-2028. |
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| Authors: | GAO Yingchun ZHANG Liang BIAN Zhengzhong |
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| Abstract: | The effects of different matrix material contents on the release of soluble drug’s mixed matrix were studied.With dissolution as guideline,and Captopril as model drug the effect of matrix material contents on the release of Captopril from hydrophilic gel matrix, wax matrix and mixed matrix were compared.The content of the matrix material had greater influence on the release of Captopril from mixed matrix than that from former single matrix. Moreover, the effect of Compritol 888 contents was more significant than that of HPMC K4M in mixed matrix. |
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| Keywords: | Captopril mixed matrix dissolution Compritol 888 |
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