| β-环糊精促进环己酮肟水解脱保护生成环己酮 |
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| 引用本文： | 石东坡,纪红兵,胡晓芳,裴丽霞,李忠.β-环糊精促进环己酮肟水解脱保护生成环己酮[J].化工学报,2008,59(9):2241-2246. |
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| 作者姓名： | 石东坡 纪红兵 胡晓芳 裴丽霞 李忠 |
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| 作者单位： | 华南理工大学传热强化与过程节能教育部重点实验室 |
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| 基金项目： | 国家自然科学基金，教育部跨世纪优秀人才培养计划 |
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| 摘 要： | 利用β-环糊精对有机物的增溶和活化性能将β-环糊精应用于环己酮肟水解脱保护反应，系统地研究了β-环糊精催化性能、反应温度、β-环糊精的量、酸的用量和种类等对环己酮肟水解脱保护反应的影响。实验结果表明，β-环糊精通过和酸共同作用，可以显著地催化环己酮肟脱保护反应，在60℃ β-环糊精加入时，反应的收率从73％提高到92％。酸及其添加的量对反应也具有明显作用，强酸对脱保护反应的效果明显优于弱酸。
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| 关 键 词： | β-环糊精 脱保护 催化 水解 环己酮肟 |
| 收稿时间： | 2007-10-16 |
| 修稿时间： | 2008-4-25
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β-Cyclodextrin promoted hydrolysis deprotection of cyclohexanone oxime to cyclohexanone |
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| SHI Dongpo,JI Hongbing,HU Xiaofang,PEI Lixia,LI Zhong.β-Cyclodextrin promoted hydrolysis deprotection of cyclohexanone oxime to cyclohexanone[J].Journal of Chemical Industry and Engineering(China),2008,59(9):2241-2246. |
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| Authors: | SHI Dongpo JI Hongbing HU Xiaofang PEI Lixia LI Zhong |
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| Abstract: | Hydrolysis of cyclohexanone oxime promoted by β-cyclodextrin is helpful for protection and deprotection of groups in organic synthesis, thus leading to environment protection.β-Cyclodextrin was used as a catalyst for the hydrolysis of cyclohexanone oxime, since it could activate the substrate and promote its solubility.Various factors including catalyst, reaction temperature, amount of β-cyclodextrin, amount and variety of acid were investigated.β-Cyclodextrin could significantly promote the hydrolysis by interacting with acid, the yield of cyclohexanone was increased from 73% up to 92% by adding β-cyclodextrin at 60℃.Besides, the variety and amount of acids greatly influenced the reaction.Strong acids were much superior to weak acids for the present deprotection reaction. |
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