| 生物大分子在纳米微孔中迁移运动的研究进展 |
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| 引用本文： | 冯剑,尚亚卓,周丽绘,刘洪来.生物大分子在纳米微孔中迁移运动的研究进展[J].化工学报,2010,61(10):2501-2509. |
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| 作者姓名： | 冯剑 尚亚卓 周丽绘 刘洪来 |
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| 作者单位： | 滁州学院化学与生命科学系;化学工程联合国家重点实验室，华东理工大学化学系 |
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| 基金项目： | 国家自然科学基金，化学工程联合国家重点实验室开放课题 |
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| 摘 要： | DNA等带电生物大分子通过各种生物膜上的纳米微孔的迁移是生命现象中的关键运动步骤之一,对这种迁移过程的研究不仅有助于了解生命运动的分子机理,在快速DNA测序、基因治疗和药物传输的控制等方面也有潜在应用价值。本文介绍了近年来关于DNA分子通过纳米微孔迁移过程在实验测定、理论分析和计算机模拟等方面的研究进展,重点关注迁移动力学及其机理,特别是迁移时间和分子链长间的标度关系等。
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| 关 键 词： | DNA 蛋白质 迁移 纳米微孔 分子模拟 |
Progress in study on translocation of biomacromolecules through a nanopore |
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| FENG Jian,SHANG Yazhuo,ZHOU Lihui,LIU Honglai.Progress in study on translocation of biomacromolecules through a nanopore[J].Journal of Chemical Industry and Engineering(China),2010,61(10):2501-2509. |
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| Authors: | FENG Jian SHANG Yazhuo ZHOU Lihui LIU Honglai |
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| Affiliation: | FENG Jian1,SHANG Yazhuo2,ZHOU Lihui2,LIU Honglai2 (1Department of Chemistry and Life Science,Chuzhou University,Chuzhou 239012,Anhui,China,2State Key Laboratory of Chemical Engineering,Department of Chemistry,East China University of Science and Technology,Shanghai 200237,China) |
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| Abstract: | Translocation of charged biological macromolecules such as DNA across biological membranes through a nanopore is one of the most crucial elementary processes of life.Study on the translocation of DNA is helpful to understand the molecular mechanism of life and explore its potential application in rapid DNA sequencing,gene therapy,drug delivery and so on.In this paper,the progresses in the investigation of translocation process of DNA through nanopore by using single-molecule electrophysiology experiments,th... |
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| Keywords: | DNA |
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