| 生物体内甲醛参与的化学反应研究进展 |
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| 引用本文： | 韩颜,江海鹏,巨修练.生物体内甲醛参与的化学反应研究进展[J].武汉工程大学学报,2018,40(1):8-16. |
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| 作者姓名： | 韩颜 江海鹏 巨修练 |
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| 作者单位： | 武汉工程大学化工与制药学院，湖北 武汉 430205 |
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| 摘 要： | 为了系统地反映内源性甲醛能与生物体内的一些重要分子，如蛋白质、核酸及神经递质等发生生理生化反应，及其对结构与功能的影响，综述了人体、动植物及微生物内源性甲醛在生物体内的产生过程、产生毒性的机制及代谢途径等方面的具体的研究成果。多数研究采用甲醛捕获剂的方法消除过量的内源性甲醛，但加入的甲醛捕获剂是否干扰机体正常的甲醛生化反应途径值得考虑。因此，采用代谢调控策略对生物机体的甲醛平衡提供指导，对于全面理解和降低内源性甲醛对生命机体的影响具有重要意义。
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| 关 键 词： | 内源性甲醛 生物机体 毒性机制 代谢途径 |
Advances in Chemical Reaction of Formaldehyde in Organisms |
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| Authors: | HAN Yan JIANG Haipeng JU Xiulian |
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| Affiliation: | School of Chemical Engineering and Pharmacy， Wuhan Institute of Technology， Wuhan 430205， China |
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| Abstract: | Aiming at the endogenous formaldehydes reacting with important molecules in organism， such as protein， nucleic acids and neurotransmitters， and affecting their structures and functions， we have systematically reviewed the research progress of endogenous formaldehyde production， the mechanism of toxicity and metabolic pathways in organisms. Recently， the most commonly used method for eliminating excess endogenous formaldehyde is to add the capture agents， however， whether the formaldehyde capture agent interferes the normal formaldehyde biochemical reaction is worth considering. Therefore， the paper proposes the metabolic regulation strategies to achieve formaldehyde balance of organisms， which is of great significance for comprehensively understanding and reducing the effects of endogenous formaldehyde on organisms. |
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| Keywords: | endogenous formaldehyde organism mechanisms of toxicity metabolic pathway |
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