| 聚碳酸酯纳米药物的制备与性能 |
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| 引用本文： | 鄢国平,邵春桃,韩林,邹头君,刘凡,龚晓芸,常秀鹏.聚碳酸酯纳米药物的制备与性能[J].武汉工程大学学报,2013(7):43-48,53. |
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| 作者姓名： | 鄢国平 邵春桃 韩林 邹头君 刘凡 龚晓芸 常秀鹏 |
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| 作者单位： | [1]武汉工程大学材料科学与工程学院,湖北武汉430074 [2]武汉工程大学绿色化工过程教育部重点实验室,湖北武汉430074 |
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| 基金项目： | 国家自然科学基金面上项目（51173140）; 武汉市科技攻关项目（2013010501010131）; 2012年地方高校第二批国家级大学生创新创业训练计划项目（1002120203）; 武汉工程大学第三届研究生创新基金（CX201144）; 武汉工程大学第四届研究生教育创新基金（CX201231）; 武汉工程大学第八期大学生校长基金项目（2013049） |
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| 摘 要： | 采用可生物降解高分子材料链接或包埋抗癌药物制备高分子纳米或微米药物,不仅可以提高药物的抗癌功效而且能减小药物对正常组织的毒副作用.以9-苯基-2,4,8,10-四氧螺5,5]十一烷-3-酮与2,2-二甲基二亚甲基合成的羟基化的碳酸酯共聚物P（PTC-co-DTC）为载体,将肿瘤靶向基团叶酸通过化学反应键连在聚碳酸酯的侧链,从而制备肿瘤靶向性高分子载体,并进行了傅立叶红外光谱、核磁共振氢谱、紫外-可见光谱等结构表征.再将靶向高分子载体与5-氟尿嘧啶复合,采用高压电场喷雾法与透析法分别制得两种肿瘤靶向聚碳酸酯纳米抗癌药物,并初步研究了纳米抗癌药物的体外药物控制释放性能.研究结果表明碳酸酯纳米药物具有较好的药物释放性能,且高压电场喷雾法制备的纳米药物比透析法制备的纳米药物释放药物速率快.
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| 关 键 词： | 生物材料 纳米药物 药物控制释放 |
Synthesis and properties of polycarbonate nanoparticles drugs |
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| Authors: | YAN Guo-ping SHAO Chun-tao HAN Lin ZOU Tou-jun LIU Fan GONG Xiao-yun CHANG Xiu-peng |
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| Affiliation: | (School of Material Science and Engineering,Wuhan Institute of Technology,Wuhan 430074,China;Key Laboratory for Green Chemical Process of Ministry of Education,Wuhan Institute of Technology,Wuhan 430074,China) |
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| Abstract: | The polymer nanoparticles and microspheres are usually prepared by the entrapment and attachment of the anticancer drugs using biodegradable polymer materials as the carriers.These drug delivery systems can not only increase anticancer efficacy,but also reduce the toxicity of drugs to normal tissues.In this work,the tumer-targeting polycarbonates were prepared by the incorporation of folic acid（FA） as a tumer-targeting group into the partly deprodected polycarbonate P（DTC-co-PTC） containing hydroxyl group.Sequently,the tumer-targeting polycarbonate anticancer nanoparticles and microspheres were prepared by the high-voltage electrostatic field-assisted atomization and dialysis methods using 5-fluorouracil（5-Fu） as an anticancer drug model and the tumer-targeting polycarbonates containing FA groups as polymer carriers.These polycarbonates anticancer nanoparticles and microspheres were further characterized and their properties in vitro were also evaluated.The drug release tests indicate that these polycarbonates anticancer nanoparticles and microspheres retain the steady 5-Fu release rates and have good controlled release properties.Moreover,polycarbonates nanoparticles prepared by high-voltage electrostatic field-assisted atomization possess faster 5-Fu release rates than that of polycarbonates anticancer microspheres prepared by dialysis method. |
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| Keywords: | biomaterials polymeric nanoparticles and microspheres drug controlled release |
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