Kaempferol,a dietary flavonoid,ameliorates acute inflammatory and nociceptive symptoms in gastritis,pancreatitis, and abdominal pain |
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Authors: | Shi Hyoung Kim Jae Gwang Park Gi‐Ho Sung Sungjae Yang Woo Seok Yang Eunji Kim Jun Ho Kim Van Thai Ha Han Gyung Kim Young‐Su Yi Ji Hye Kim Kwang‐Soo Baek Nak Yoon Sung Mi‐nam Lee Jae Youl Cho |
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Affiliation: | 1. Department of Genetic Engineering, Sungkyunkwan University, Suwon, Republic of Korea;2. Institute for Bio‐medical Convergence, College of Medicine, Catholic Kwandong University, Gangneung, Republic of Korea;3. International St. Mary's Hospital, Catholic Kwandong University, Incheon, Republic of Korea;4. Department of Food and Nutrition, School of Foodservice Industry, Chungkang College of Cultural industries, Icheon, Republic of Korea |
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Abstract: | Kaempferol (KF) is the most abundant polyphenol in tea, fruits, vegetables, and beans. However, little is known about its in vivo anti‐inflammatory efficacy and mechanisms of action. To study these, several acute mouse inflammatory and nociceptive models, including gastritis, pancreatitis, and abdominal pain were employed. Kaempferol was shown to attenuate the expansion of inflammatory lesions seen in ethanol (EtOH)/HCl‐ and aspirin‐induced gastritis, LPS/caerulein (CA) triggered pancreatitis, and acetic acid‐induced writhing. |
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Keywords: | Abdominal pain Anti‐inflammatory effect Gastritis Kaempferol Pancreatitis |
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