Effect of different solvents on the chemical composition,antioxidant activity and alpha‐glucosidase inhibitory activity of hawthorn extracts |
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| Authors: | Jing Miao Xia Li Yaya Fan Chengcheng Zhao Xinhui Mao Xuetao Chen Hanhan Huang Wenyuan Gao |
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| Affiliation: | Tianjin Key Laboratory for Modern Drug Delivery & High‐Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China |
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| Abstract: | The aim was to investigate chemical composition of different extracts prepared from hawthorn fruit using 80% ethanol, 80% methanol, 80% acetone and pure deionised water, and evaluate their antioxidant and anti‐alpha‐glucosidase activities. The highest alpha‐glucosidase inhibitory activity was determined in 80% acetone extract, while the highest DPPH scavenge capacity and ferric reducing power both exhibited in deionised water extract. In the correlation analysis, polyphenols, triterpenoids, protocatechuic acid and epicatechin all contribute to the alpha‐glucosidase inhibitory activity, while flavonoids, polyphenols, vanillic acid, gallic acid, catechin and chlorogenic acid all contribute to the antioxidant activity. By HPLC‐MS, thirty six compounds were identified, and fifteen of them were found from hawthorn fruits for the first time. Our results would provide a good reference for the further study on the antidiabetes activity of hawthorn, and also support that deionised water extract has the potential to be used as ingredients of functional food products. |
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| Keywords: | Alpha‐glucosidase inhibitory antioxidant hawthorn polyphenols triterpenes |
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