This study was to explore the application value of back propagation (BP) neural network (BPNN) and genetic algorithm (GA) in the combined detection and prognosis of tumor markers in patients with gallbladder cancer. 446 patients with gallbladder cancer were included in the experimental group, 279 patients with benign gallbladder disease were included in the control group, and 188 healthy people were selected and included in the blank group. Serum tumor markers (CA242, CA199, CEA, and CA125) of the three groups were detected by electrochemical luminescent immune analyzer, and follow-up data for 5 years after surgery were collected. Based on BPNN and GA, an optimization algorithm for multi-tumor markers was constructed and applied to the combined detection of tumor markers in patients. The artificial neural network (ANN), dynamic network biomarker (DNB), auxiliary diagnosis algorithm of the support vector machine (SVM) based on the particle swarm optimization (PSO) (PSO-SVM), matched-pairs feature selection (MPFS) based on the machine learning, and the BPNN were introduced to compare with the algorithm constructed. The diagnostic performances of the algorithms were evaluated with the fivefold cross-validation method. The results showed that the levels of CanAg (CA) 242, carcinoma embryonic antigen (CEA), CA199, and CA125 and positive rates in the experimental group were significantly higher than those in the control group and the blank group (P?<?0.05); but the differences between control group and blank group were not visible (P?>?0.05). The sensitivity (91.72%) and specificity (87.49%) in detecting CA242 and CA199 based on the proposed algorithm were the highest; the sensitivity (0.9186), specificity (0.8622), and accuracy (94.94%) of the proposed algorithm were higher than those of the conventional algorithms. The postoperative follow-up survival rate of patients in the experimental group was reduced from 41.72% in the first year to 4.28% in the fifth year; tumor node metastasis (TNM) stage IV, neck gallbladder cancer, and CA199 were significantly correlated with the survival rate of patients in the experimental group (P?<?0.05). In summary, the combined detection technology of multiple tumor markers based on deep learning algorithms showed excellent diagnostic and prognostic performance for gallbladder cancer. The occurrence of gallbladder cancer was related to the tumor markers CA242, CA199, CEA, and CA125, showing better detection effects by combination of CA242 and CA199. The TNM stage IV, neck gallbladder cancer, and CA199 were independent risk factors for the decrease in survival rate of patients with gallbladder cancer.
相似文献Based on the dual-inheritance framework of cultural evolution, an improved multiobjective cultural algorithm (IMOCA) with a multistrategy knowledge base is presented in this paper. Inspired by the original versions of the cultural algorithm (CA), four basic types of knowledge sources, i.e., normative, situational, topographical and historical knowledge, are effectively utilized in the proposed IMOCA. Several modifications with the knowledge base of the IMOCA are made to tackle the characteristics of the multiobjective problem. Situational knowledge is used as an external repository for storing elite individuals, and the redesigned topographical knowledge functions as a search engine to broaden the expansion of the obtained solution set. The historical knowledge used in the IMOCA aims to select a productive knowledge source to generate new individuals. Furthermore, a simple mutation scheme is introduced into the knowledge base as an influence function for the purpose of fine tuning in the late stage of search. After configuring the parameters used in IMOCA, two classic benchmark suites, i.e., WFG and MaF, are used to assess the performance of the IMOCA in approaching the Pareto fronts (PFs) with accuracy and diversity. Nondominated solution sets obtained by the IMOCA are compared with 8 state-of-the-art multiobjective algorithms available in the literature. A statistical analysis is conducted, which reveals that, by modifying the basic knowledge structure of the CA, the proposed multiobjective cultural algorithm is competent enough to handle multiobjective problems with competitive performance.
相似文献Due to the important role of concrete in construction sector, a novel metaheuristic method, namely whale optimization algorithm (WOA), is employed for simulating 28-day compressive strength of concrete (CSC). To this end, the WOA is coupled with a neural network (NN) to optimize its computational parameters. Also, dragonfly algorithm (DA) and ant colony optimization (ACO) techniques are considered as the benchmark methods. The CSC influential parameters are cement, slag, water, fly ash, superplasticizer (SP), fine aggregate (FA), and coarse aggregate (CA). First, a population-based sensitivity analysis is carried out to achieve the most efficient structure of the proposed model. In this sense, the WOA-NN with the population size of 400 and five hidden nodes constructed the best-fitted network. The results revealed that the WOA-NN (Error = 2.0746 and Correlation = 0.8976) presents the most reliable prediction of the CSC, followed by the DA-NN (Error = 2.5138 and Correlation = 0.8209) and ACO-NN (Error = 2.8843 and Correlation = 0.8000) benchmark models. The findings showed that utilizing the WOA optimization technique, along with typical neural network, results in developing a promising tool for modeling the CSC.
相似文献A new optimization algorithm is proposed, since a huge problem that many algorithms faced was not being able to effectively balance the global and local search ability. Matter exists in three states: solid, liquid, and gas, which presents different motion characteristics. Inspired by multi- states of matter, individuals of optimization algorithm have different motion characteristics of matter, which could present different search ability. The Finite Element Analysis (FEA) approach can simulate multi- states of matter, which can be adopted to effectively balance the global search ability and local search ability in new optimization algorithm. The new algorithm is creative application of Finite Element Analysis at optimization algorithm field. Artificial Physics Optimization (APO) and Gravitational Search Algorithm (GSA) belongs to the algorithm types defined by force and mass. According to FEA approach, node displacement caused by force and stiffness could be equivalent to motion caused by force and mass of APO and GSA. In the new algorithm framework, stiffness replaces mass of APO and GSA algorithm. This paper performs research on two different algorithms based on APO and GSA respectively. The individuals of new optimization algorithm are divided into solid state, liquid state, and gas state. The effects of main parameters on the performance were studied through experiments of 6 static test functions. The performance is compared with PSO, basic APO, or GSA for four complex models which made up of solid individual, liquid individual, and gas individual in iterative process. The reasonable complex model can be confirmed experimentally. Based on the reasonable complex model, the article conducted complete experiments against Enhancing artificial bee colony algorithm with multi-elite guidance (MGABC), Artificial bee colony algorithm with an adaptive greedy position update strategy (AABC), Multi-strategy ensemble artificial bee colony (MEABC), Self-adaptive heterogeneous PSO (fk-PSO), and APO with 28 CEC2013 test problem. Experimental results show that the proposed method achieves a good performance in comparison to its counterparts as a consequence of its better exploration– exploitation balance. The algorithm supplies a new method to improve physics optimization algorithm.
相似文献This paper investigates the design of concentric circular antenna arrays (CCAAs) with optimum side lobe level reduction using the Symbiotic Organisms Search (SOS) algorithm. Both thinned and full CCAAs are considered. SOS represents a rather new evolutionary algorithm for antenna array optimization. SOS is inspired by the symbiotic interaction strategies between different organisms in an ecosystem. SOS uses simple expressions to model the three common types of symbiotic relationships: mutualism, commensalism, and parasitism. These expressions are used to find the global minimum of the fitness function. Unlike other methods, SOS is free of tuning parameters, which makes it an attractive optimization method. The results obtained using SOS are compared to those obtained using several optimization methods, like Biogeography-Based Optimization (BBO), Teaching-Learning-Based Optimization (TLBO), and Evolutionary Programming (EP). It is shown that the SOS is a robust straightforward evolutionary algorithm that competes with other known methods.
相似文献Evolutionary computing algorithms are computational intelligent systems that are used in a wide range of research applications, primarily for optimization. In this paper, an artificial neural network (ANN), a machine learning technique, is used to classify the data. The weights associated with each neuron and the architecture of the neural network always bias the output of the network model. With prior knowledge or trial and error techniques, different metrics or objectives can be used to optimise these weights. The optimization of weights using multiple objectives refers to a "multi-objective optimization problem." In this paper, an evolutionary cultural algorithm is used to optimise weights in ANN, and the results are reported with improved accuracy. Three benchmark datasets for autism screening data are used, trained, and tested for model accuracy in the classification: toddlers (1054,19), children (292,21), and adults (704,21).With the support of the domain expert, real-time data were collected from parents and caregivers and totalled over 1000 records, with a moderate difference in attributes based on CARS-2 (Childhood Autism Rating Scale, 2nd Edition) for ASD screening. In this paper, the proposed model is compared using a curve-fitting mathematical technique. The proposed model is trained and tested, and the results showed that it outperformed other algorithms in terms of precision, accuracy, sensitivity, and specificity.
相似文献Harris Hawk Optimization (HHO) algorithm is a new population-based and nature-inspired optimization paradigm, which has strong global search ability, but its diversified local search strategies easily make it fall into local optimum. In order to enhance its search mechanism and speed of convergence, an new improved HHO algorithm based on the inverse cumulative function operator of Cauchy distribution and tangent flight operator was proposed. The proposed two operators are used as scale factors to control the step size. The walk path of Cauchy inverse cumulative integral function shows that its trajectory step length is relative to the average, which can further enhance the search stability of the algorithm. The Tangent flight has the function of balanced exploitation and exploration, and enhances the convergence ability of the algorithm. In order to verify the performance of the proposed algorithm, the 30 benchmark functions of the 2017 Institute of Electrical and Electronic Engineers (IEEE) Conference on Evolutionary Computation (CEC2017) and two practical engineering design problems are adopted to carry out the simulation experiments. On the other hand, the covariance matrix adaptation evolutionary strategies (CMA-ES), arithmetic optimization algorithm (AOA), butterfly optimization algorithm (BOA), bat algorithm (BA), whale optimization algorithm (WOA), sine cosine algorithm (SCA), and the proposed HHO algorithms were used for comparison experiments. Simulation results show that the proposed the Cauchy-distribution and Tangent-Flight Harris Hawk Optimization (CTHHO) Algorithm has strong optimization capability.
相似文献针对缓冲区有限的多目标流水车间调度问题, 提出一种基于Pareto 最优的广义多目标萤火虫算法. 通过引入交换子和交换序将基本萤火虫算法离散化, 并将算法拓展为全局搜索过程和局部搜索过程. 进化初期采用全局搜索将种群推向较优区域, 进化中后期采用捕食搜索策略使算法主体在全局搜索和局部搜索间智能切换, 从而保证全局与局部的平衡. 动态变步长策略进一步增强了算法搜索能力. 通过算例测试验证了所提出算法的有效性.
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