共查询到19条相似文献,搜索用时 656 毫秒
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手性膜分离法作为一种新兴的手性分离技术,具有高效、简便、低能耗、可连续操作等特点,在手性分离领域具有巨大的潜力。但近几十年的研究表明,传统手性聚合物材料选择性差、渗透通量低、稳定性差,且难以打破选择性与渗透通量之间的制约关系。这是膜拆分性能无法大幅提高的症结所在,导致膜分离领域长时间处于发展的瓶颈期。近年来,已有许多学者针对这些问题,寻找手性位点更加丰富、稳定性更强、能够提供更多分子通道的新型材料。重点介绍了近5年来基于碳纳米材料、金属有机框架(MOF)、共价有机框架(COF)、改良手性聚合物和一些其他无机材料的新型手性固体膜的合成和应用,并对这些材料的优缺点进行了总结和讨论,以期推动固体膜手性分离技术的进步。另外,还对膜分离机制的研究进展进行了总结,并特别讨论了新材料在手性膜中的作用机制,为进一步改善膜拆分性能提供理论基础。 相似文献
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甲壳素是一种丰富的可再生资源,将甲壳素在碱性条件下脱去乙酰基得到壳聚糖,甲壳素和壳聚糖分子骨架有大量的手性碳原子存在,且含有较多的羟基、乙酰氨基或氨基活性官能团,容易进行化学改性得到有较好手性识别能力的衍生物,且它们能以膜、纤维、凝胶及微球等不同形式出现,可作为各种手性分离介质。概述了近年来甲壳素衍生物作为手性分离介质的重要研究进展,主要包括甲壳素及其衍生物的色谱手性固定相、手性分离膜、分子印迹聚合物。重点介绍了这些手性分离介质的结构、制备及性能,并展望了甲壳素衍生物手性分离介质的研究前景。 相似文献
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以聚乙烯醇为基材,加入β环糊精作为手性选择剂,加入聚丙烯酸促进离子传递,制得具有手性选择性的阳离子交换膜.通过电渗析过程分离DL-苯甘氨酸.改变原料中D-苯甘氨酸与L-苯甘氨酸的比例,一级电渗析实验结果表明均为D-苯甘氨酸优先通过手性阳膜,分离系数1.05,且基本不随原料组成变化.二级电渗析可以把过程的分离系数提高到1.10左右. 相似文献
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合成了含有3,5-二甲基和3,5-二氯取代基团的混合型淀粉(苯基氨基甲酸酯)衍生物(CSP-2),并作为手性体分离材料涂敷在氨丙基化多孔硅胶表面,制得新型高效液相色谱(HPLC)用手性固定相;通过1H核磁共振(1H NMR)和红外光谱(IR)表征衍生物结构;以正己烷-异丙醇(9∶1,v/v)为流动相,对多种手性对映体进行了拆分;结果表明,CSP-2综合了单一取代基团淀粉(苯基氨基甲酸酯)衍生物的手性拆分性能,具有优越的手性分离能力,同时固定相的稳定性大大增强。 相似文献
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Chiral surfaces attract increasing interest due to their vital role in a variety of scientific fields, such as chiral separation and heterogeneous enantioselective catalysis. The most urgent issue in research on such two-dimensional chirality is a lack of methodologies that recognize molecular chirality on a surface. Here we show that the chiral molecular tips enable for the first time discrimination of enantiomers on a single-molecule basis. The chiral selectivity is attributed to favorable chemical interactions that the molecular tips form with only one of two enantiomers. The stereoselective observation reveals spatial distribution of the enantiomers on a surface at the molecular level. The chiral molecular tips open a way for control of organization of enantiomers toward the advanced functionality of these chiral surfaces through knowledge on pivotal roles of chirality on molecular assemblies as shown here. 相似文献
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Lin JY 《Applied optics》2008,47(21):3828-3834
This study develops a method for determining the chiral parameter and the refractive index of an isotropic chiral medium using chiral reflection equations and critical angle phenomena. Linearly polarized light propagates back and forth in a parallelogram prism between two parallel compartments with chiral solutions. A beam splitter then divides the light that emerges from the prism into a reflected light beam and a transmitted light beam. The two beams pass through a compensator and an analyzer, respectively, to cause phase compensation and interference of s and p polarizations. The phase difference between the two interference signals are initially optimized by a suitable optical arrangement and subsequently measured by heterodyne interferometry. Additionally, the refractive index of the solution is determined from the critical angle that occurred at the discontinuity of the phase difference between the two interference signals. These results are substituted into derived equations to calculate the chiral parameter. The approach has the merits of both common-path interferometry and heterodyne interferometry. 相似文献
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《晶体工程》2000,3(3):209-224
Our recent studies have shown that cocrystallization of 1:1 solutions of (R)-X and (S)-X′ (where X and X′ represent two sterically similar molecules) often form quasiracemic crystals, in which approximately centrosymmetric molecular pairs cocrystallize in an arrangement that resembles a “true” racemic structure. As part of an ongoing study of the influence of molecular shape on crystal packing, the present work centers on the design, synthesis and X-ray structure determination of four homologous N-(α-methylbenzyl)-4-substituted benzenesulfonamides. Crystallization of a solution of these (±)-arylsulfonamides unexpectedly yields enantiomerically pure crystals via a Pasteurian-type resolution process. This mode of crystallization presumably also deters the cocrystallization of different, but structurally similar, arylsulfonamides to form quasiracemates. The X-ray crystal structures of the four sulfonamides reveal the dominance of N–H⋅⋅⋅O–S hydrogen bonds that form infinite helical C(4) molecular chains. For three of the structures this pattern is extended by short inter- and intramolecular π⋅⋅⋅π interactions to form two-dimensional molecular architectures. 相似文献
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The living world is chiral. Chirality or the handedness of a structure or molecule is at the heart of life itself. Recently, it has been shown that plasmonic structures exhibit unprecedented and gigantic chiral optical responses. Here we show that truly three-dimensional arrangements of plasmonic "meta-atoms" only exhibit a chiral optical response if similar plasmonic "atoms" are arranged in a handed fashion as we require resonant plasmonic coupling. Moreover, we demonstrate that such particle groupings, similarly to molecular systems, possess the capability to encode their three-dimensional arrangement in unique and well-modulated spectra making them ideal candidates for a three-dimensional chiral plasmon ruler. Our results are crucial for the future design and improvement of plasmonic chiral optical systems, for example, for ultrasensitive enantiomer sensing on the single molecule level. 相似文献
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In this article, we examine the docking of 10 analytes on the Whelk-O1 stationary phase. A proper representation of analyte flexibility is essential in the docking analysis, and analyte force fields have been developed from a series of B3LYP calculations. Molecular dynamics simulations of a representative Whelk-O1 interface, in the presence of racemic analyte and solvent, form the basis of the analysis of chiral selectivity. The most probable docking arrangements are identified, the energy changes upon docking are evaluated, and separation factors are predicted. From comparisons between the analytes, the mechanism of chiral selectivity is divided into contributions from hydrogen bonding, ring-ring interactions, steric hindrance, and molecular flexibility. We find that both hydrogen bonding and ring-ring interactions are necessary to localize the analyte within the Whelk-O1 cleft region. We also identify one docking mechanism that is often dominant and analyze the conditions that lead to alternate docking modes. 相似文献
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A sensitivity-enhanced field-effect chiral sensor 总被引:1,自引:0,他引:1
Torsi L Farinola GM Marinelli F Tanese MC Omar OH Valli L Babudri F Palmisano F Zambonin PG Naso F 《Nature materials》2008,7(5):412-417
Organic thin-film transistor sensors have been recently attracting the attention of the plastic electronics community for their potential exploitation in novel sensing platforms. Specificity and sensitivity are however still open issues: in this respect chiral discrimination-being a scientific and technological achievement in itself--is indeed one of the most challenging sensor bench-tests. So far, conducting-polymer solid-state chiral detection has been carried out at part-per-thousand concentration levels. Here, a novel chiral bilayer organic thin-film transistor gas sensor--comprising an outermost layer with built-in enantioselective properties-is demonstrated to show field-effect amplified sensitivity that enables differential detection of optical isomers in the tens-of-parts-per-million concentration range. The ad-hoc-designed organic semiconductor endowed with chiral side groups, the bilayer structure and the thin-film transistor transducer provide a significant step forward in the development of a high-performance and versatile sensing platform compatible with flexible organic electronic technologies. 相似文献
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《晶体工程》2001,4(2-3):113-118
The importance of obtaining reliable detection systems for enantiomers' assays increases with the necessity of chiral discrimination between the enantiomers of raw materials from the pharmaceutical industry. The utilization of electrochemical sensors in molecular recognition of chiral substances becomes a very accurate and precise alternative for the structural analysis as well as for the chromatographic techniques. The reliability of the response characteristics as well as of the analytical information obtained by using electrochemical sensors is strictly correlated with the design of the sensors. The most reliable design is that of carbon paste based sensors; this design was adopted for the construction of potentiometric, enantioselective membrane electrodes as well as for the construction of the amperometric biosensors, and immunosensors. However, it is also necessary to look for more reliable chiral selectors. 相似文献
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An electric line source illumination of a chiral cylinder embedded in a chiral background medium is considered. The field expressions inside and outside of a chiral cylinder have been derived using the wave field decomposition approach. The effects of various chiral cylinders, chiral background media and source locations upon the scattering gain pattern have been investigated. It is observed that the chiral background reduces the backward scattering gain as compared to the free space background for a dielectric cylinder. It is also studied that by moving a line source away from a cylinder reduces the backward scattering gain for a chiral cylinder placed in a chiral background under some specific conditions. A unique phenomenon of reduced scattering gain has been observed at a specific observation angle for a chiral cylinder placed in a chiral background having an electric line source location of unity free space wavelength. An isotropic scattering gain pattern is observed for a chiral nihility background provided that if cylinder is chiral or chiral nihility type. It is also observed that this isotropic behaviour is independent of background and cylinder chirality. 相似文献