Frequency, distribution and clonality of chromosome damage in human lymphocytes by multi-color FISH

Behavioral studies and reports in the pediatric medical literature suggest that children, particularly those younger than 4 years, frequently place foreign objects such as toys and small parts of consumer products in their mouths, nasal cavities and ear canals. These actions not infrequently lead to injury or death. Accurate models of the anatomical areas most often severely injured by foreign body impaction (oral cavity, orbit, ear canal and nasal passages) would greatly facilitate assessment of the risks of impaction. Because models of these anatomic regions in children of the ages when they are most at risk are not widely available, Intertek Testing Services, Risk Analysis and Management (ITS RAM), in association with faculty at the University of Pittsburgh and the Pittsburgh Supercomputing Center at Carnegie Mellon University, developed computerized models of these anatomical areas of interest in children at the critical stages of child development. Computer models were also developed of proposed or existing products and of objects represented in the ITS RAM Small Parts Aspiration and Ingestion Database (comprised of data from 17 children's hospitals) and fatality data from the Consumer Product Safety Commission. The computer models of products and computer anatomical models can be used to assess the possible hazards inherent in the product designs and to communicate the risks associated with product designs to manufacturers and marketing groups.     

Heat-transfer phenomena in water-cooled zinc-fuming furnace jackets

In the zinc slag-fuming process, zinc is removed from lead blast furnace slag by reduction with a coal-air mixture injected into the slag through submerged tuyeres. The furnace is constructed of water-cooled jackets which freeze a slag layer and contain the bath. This greatly reduces vessel wear caused by the violently agitated and corrosive bath. The jackets, however, fail due to the formation of cracks which grow from the slag face through the working face of the jacket to the water channel. In this study, in-plant measurements and mathematical modeling of heat transfer in the jackets have been combined to elucidate the mechanism of failure. The working face of a water jacket was instrumented with thermocouples and installed in a fuming furnace at the Trail smelter of Cominco Ltd., Trail, BC. Measurements revealed the presence of large thermal transients or temperature “spikes” in the panel in the region immediately above the tuyeres. These were generally observed during charging and tapping of the furnace and are likely associated with disturbances on the surface of the bath or gas injection effects when the liquid level is low. Temperatures at the midthickness were seen to rise by as much as 180 °C above the steady-state level. Under these conditions, low-cycle fatigue may lead to crack formation and propagation. A mathematical modeling analysis of the transient freezing phenomena indicates that the temperature spikes are associated with sudden slag falloff and direct contact of molten slag on the jacket. In order to reduce slag falloff, an increased number of anchoring fins should be used in critical areas.     

浸入式水口缺陷成因及对板坯的影响

通过分析浸入式水口缺陷产生原因及对铸坯夹杂的影响,提出了不同种类缺陷铸坯的处理措施。实践表明,浸入式水口渣线或侧孔处整齐断裂的缺陷板坯经四面火焰清理后可以正常轧制,水口断裂有裂纹及渣线处孔洞缺陷板坯应根据实际情况做相应的报废处理。     

Gene amplifications in advanced-stage human prostate cancer

OBJECTIVES: The pulpal reaction and the marginal sealing of in vivo restored samples using resin composite and Scotchbond Multi-Purpose adhesive system (3M Dental Products) were analyzed in this study. METHODS: Twelve Class I non-exposed cavity preparations were placed on premolars to be removed for orthodontic reasons. They were restored and observed at 7 d and 28 d. RESULTS: The examination of the resin-dentin interface under the scanning electron microscope (SEM) revealed: 1) a gap-free attachment between adhesive resin and dentinal surface in 80% of the areas studied, 2) penetration of resin tags into the dentinal tubules, and 3) formation of a 3-5 micrometer thick acid-resistant hybrid layer. Microfissures measuring about 10 micrometers were observed in only 20a% of the areas studied; these were located along the walls of the cavities, especially near the enamel in zones where there was a lower concentration of dentinal tubules. The histological analysis, carried out 7 d after preparation of the restoration, did not show any alteration of the pulp. After 4 wk, reparative dentin was produced in the pulpal areas corresponding to the restored cavities. SIGNIFICANCE: The quantity of newly formed dentin is correlated with the distance from the cavity to the pulp. The results indicate that acid-etching of vital dentin using 10% maleic acid does not impair pulpal healing in deep Class I cavities and that the Scotchbond Multi-Purpose adhesive system is able to preserve the morphological and biological integrity of the pulpo-dentinal complex.     

Influence of Sluice Gate Contraction Coefficient on Distinguishing Condition

Sluice gates are widely used for flow control in open channels. Flow through the gate may be free or submerged depending on tailwater depth. One may determine whether the flow will be free or submerged by determining the maximum tailwater level that permits free flow. This is called the distinguishing condition. This paper derives a theoretical equation for the distinguishing condition including the contraction coefficient as a parameter, based on the basic equations for free flow and the hydraulic jump. The equation is investigated using experimental data from two different gate types. The results show that the contraction coefficient varies with gate type and that this affects the distinguishing condition. The results also show that for a given upstream depth, tainter gates (radial gates) are less likely to become submerged than vertical gates due to larger contraction coefficients. The present study results are useful in the design and operation of sluice gates.     

Interaction of alumina inclusions in steel with calcium-containing materials

Clogging of tundish and submerged entry nozzles (SENs) adversely impacts productivity and quality in the continuous casting of aluminum-killed steels. Clogging results from an accretion layer that develops on the inside surface of the nozzle and restricts steel flow. Current nozzle refractories often react with molten steel to form solid by products that promote clogging. Nozzle materials that are inert with the liquid steel or react with accretions to form liquid reaction products could inhibit or eliminate clogging. Static experiments were conducted to investigate the stability between calcium-based materials and aluminum-killed steel. The results indicate that both calcium titanate and calcium zirconate react with alumina to form calcium aluminates. However, only the reaction between alumina and calcium titanate yielded calcium aluminate chemistries that were molten at steel casting temperatures. Liquid reaction products are preferred since they would be removed from the nozzle by the steel flow, thereby preventing accretion formation and clogging.     

Bubble Formation at a Submerged Orifice for Aluminum Foams Produced by Gas Injection Method

The bubble formation at a submerged orifice in the process of aluminum foams produced by gas injection method is investigated. The experimental results show that the increase of the gas flow rate and the orifice diameter can lead to increasing of the bubble size. The large orifice can make the frequency of bubble formation decrease by slowing down the increase of the gas chamber pressure when the gas flow rate increases. The effect of the gas chamber volume on the bubble size can be ignored in the experiment when it expands from 1 to 125 cm³. A theoretical model of bubble formation, expansion, and detachment under constant flow conditions is established to predict the bubble size. The theoretical predictions for air-aluminum melt systems are consistent with the experimental results.     

Evaluation of fetal condition in pregnancy complicated by hypertension--biochemical assessment of amniotic fluid. I. Protein and lipid components and kidney maturation

Leiomyoma is a benign tumor that originates from the smooth muscle. If often develops in the uterus and in organs rich of smooth muscle like bowel and subcutaneous tissue. It is infrequently observed in the oral nasal cavities or in paranasal sinuses. The authors, after an accurate revision of the literature, present their first case of zygomatic leiomyoma. They underline the diagnostic aspects in relationship to histologic and immunohistochemical examinations, for surgical therapy.     

Intergroup relations: insights from a theoretically integrative approach

In social psychology, specific research traditions, which often spring up in response to external events or social problems, tend to perpetuate the theoretical assumptions and methodological approaches with which they began. As a result, theories and methods that have proven powerful in 1 topic area are often not applied in other areas, even to conceptually similar issues. The authors adopt a theoretically integrative approach to the topic of intergroup relations. Theories and empirical approaches from the domains of attitudes, impression formation, the self, personal relationships, and norms offer many new insights into problematic issues, such as repeated findings of dissociations among stereotyping, prejudice, and discrimination. This integrative approach not only promises new theoretical advances, but also suggests numerous potential practical approaches to limiting or reducing destructive patterns of intergroup relations.     

Mastoid obliteration in open cavities

The obliteration of a large or irregular mastoidectomy cavities with hard-to-control areas is a common problem for ENT surgeons. Numerous obliteration techniques have been proposed in the last 50 years. We report our experience of obliteration of mastoid cavities in 74 ears using autogenous mastoid cortical bone chips and rib cartilage. Our procedure, a partial obliteration with meatoplasty, has yielded good results. Almost 92% of these ears were dry three years after surgery. There were no cases of recurrent cholesteatoma between bone chips.     

低成本高焊接性能船板钢EH36的开发

工业化试制了3种厚度规格(20,26和36mm)的新型低成本高焊接性能船板钢EH36。试制钢板的显微组织由多边形铁素体和针状铁素体构成,其力学性能满足EH36级别船板要求并具有优异的低温韧性。采用焊接热模拟评价了钢板的焊接性能,当热输入由30kJ/cm升高至160kJ/cm时,粗晶区原奥氏体晶粒尺寸逐渐增大,其组织也逐渐由粒状贝氏体向晶界铁素体+晶内针状铁素体+晶内多边形铁素体转变,维氏硬度逐渐下降,低温韧性优异。得益于TiN粒子对奥氏体晶粒长大的抑制作用,微量B元素对先共析铁素体转变的抑制作用以及BN粒子对晶内铁素体形核的促进作用,焊接粗晶区获得了有利于韧性的细化组织,保证了粗晶区具有优异的低温韧性。双丝埋弧焊试验也验证了钢板具有优异的焊接性能。     

Cavity formation from inclusions in ductile fracture

The previously proposed conditions for cavity formation from equiaxed inclusions in ductile fracture have been examined. Critical local elastic energy conditions are found to be necessary but not sufficient for cavity formation. The interfacial strength must also be reached on part of the boundary. For inclusions larger than about 100? the energy condition is always satisfied when the interfacial strength is reached and cavities form by a critical interfacial stress condition. For smaller cavities the stored elastic energy is insufficient to open up interfacial cavities spontaneously. Approximate continuum analyses for extreme idealizations of matrix behavior furnish relatively close limits for the interfacial stress concentration for strain hardening matrices flowing around rigid non-yielding equiaxed inclusions. Such analyses give that in pure shear loading the maximum interfacial stress is very nearly equal to the equivalent flow stress in tension for the given state of plastic strain. Previously proposed models based on a local dissipation of deformation incompatibilities by the punching of dislocation loops lead to rather similar results for interfacial stress concentration when local plastic relaxation is allowed inside the loops. At very small volume fractions of second phase the inclusions do not interact for very substantial amounts of plastic strain. In this regime the interfacial stress is independent of inclusion size. At larger volume fractions of second phase, inclusions begin to interact after moderate amounts of plastic strain, and the interfacial stress concentration becomes dependent on second phase volume fraction. Some of the many reported instances of inclusion size effect in cavity formation can thus be satisfactorily explained by variations of volume fraction of second phase from point to point. This work has been presented in part orally at the Third International Conference on Fracture in Munich, Germany April 1973.     

Cavity formation from inclusions in ductile fracture

The previously proposed conditions for cavity formation from equiaxed inclusions in ductile fracture have been examined. Critical local elastic energy conditions are found to be necessary but not sufficient for cavity formation. The interfacial strength must also be reached on part of the boundary. For inclusions larger than about 100Å the energy condition is always satisfied when the interfacial strength is reached and cavities form by a critical interfacial stress condition. For smaller cavities the stored elastic energy is insufficient to open up interfacial cavities spontaneously. Approximate continuum analyses for extreme idealizations of matrix behavior furnish relatively close limits for the interfacial stress concentration for strain hardening matrices flowing around rigid non-yielding equiaxed inclusions. Such analyses give that in pure shear loading the maximum interfacial stress is very nearly equal to the equivalent flow stress in tension for the given state of plastic strain. Previously proposed models based on a local dissipation of deformation incompatibilities by the punching of dislocation loops lead to rather similar results for interfacial stress concentration when local plastic relaxation is allowed inside the loops. At very small volume fractions of second phase the inclusions do not interact for very substantial amounts of plastic strain. In this regime the interfacial stress is independent of inclusion size. At larger volume fractions of second phase, inclusions begin to interact after moderate amounts of plastic strain, and the interfacial stress concentration becomes dependent on second phase volume fraction. Some of the many reported instances of inclusion size effect in cavity formation can thus be satisfactorily explained by variations of volume fraction of second phase from point to point.     

Mathematical Modeling of Lake Tap Flows

A lake tap is the submerged piercing of a tunnel at the intake to connect the reservoir to the tunnel system. It is referred to as a dry lake tap if the tunnel is dry before the blasting of the last rock plug at the tunnel entrance. Transient state conditions in the tunnel following a dry lake tap are modeled using the lumped and distributed-system approaches. Fourth-order Runge-Kutta method and the method of characteristics are used in the lumped-system model and distributed-system models, respectively. The results computed by the lumped and distributed-system approaches agree with one another. Pressures computed by using distributed-system and lumped-system models are compared with the experimental results available in literature for rapid filling of a pipeline with closed end. The rate of dissipation of pressure oscillations in the measured air pressure during prototype lake tap at Crater Lake Snettisham project in Alaska, and in the experiments reported in the literature is higher than that computed by the mathematical models using steady state friction and constant wave velocity.     

Energy and Momentum Velocity Coefficients for Calibrating Submerged Sluice Gates in Irrigation Canals

There is renewed interest in developing calibration methods for gates operating in submerged conditions in irrigation canals. In the present study, a new method based on a generalization of the standard energy-momentum method that accounts for variations in the energy and momentum velocity coefficients is proposed, for the following reasons. First, it was found that the assumption of uniform submerged jet velocity to account for the kinetic energy head and momentum flux is in reality equivalent to assuming a parabolic relationship between the Coriolis and Boussinesq coefficients. Second, literature investigations showed that the coefficients for the downstream side of submerged gates are notably greater than unity, and the implicit parabolic relationship between these coefficients in the standard energy-momentum method is inadequate, at least for high submergence conditions. The proposed energy-momentum method was evaluated using the data obtained from four gates operating in an irrigation canal in Southern Spain. Improvements in accuracy compared to the standard energy-momentum method (with a constant contraction coefficient Cc = 0.61) were obtained. The results indicate that the calibration of coefficient approach provides a means to improve the energy-momentum method by (indirectly) accounting more accurately for nonuniform velocity effects in the energy-momentum equations.     

Thermodynamic modeling as a strategy for casting highly alloyed steels

 Oxides are encountered in steel plant operations, such as in steel making and continuous casting - in the form of fluxes, slags and refractories. Further, oxidation of some readily oxidizable elements often takes place - leading to certain difficulties in the process. The formation / presence of certain oxides can lead to problems such as clogging of Submerged Entry Nozzle during continuous casting. Difficulties associated with the oxides of Aluminium and Chromium have been reported in the literature. Strategies based on thermodynamic calculations can be used to overcome the problems associated with such oxides. Approaches to enable sustained casting of highly alloyed steels have been taken up in the present study. One of the strategies to avoid the oxidation of Chromium is to add small amounts of other elements (subject to other constraints), which do not cause subsequent problems. The problem has been studied using the Thermo-CalcR software, with related databases; and, the results obtained for different process conditions / generic compositions have been presented in this paper.     

Cavity formation during tensile straining of particulate and short fibre metal matrix composites

The formation of cavities in commercially pure aluminium composites, made by both powder and casting routes and reinforced with alumina (short fibres, angular particles and spherical particles), has been monitored using periodic density measurements during tensile testing and microstructural examinations. Stable cavities always form well before final failure, usually adjacent to the reinforcement, particularly when it is elongated in the loading direction and has a relatively flat surface normal to the stress axis. Sharp corners are not favoured cavitation sites and cavities can form at spherical particles, although the incidence is somewhat less than for angular particles. Cavitation occurred earlier for higher reinforcement contents and with powder-route, as opposed to cast, material, although the void contents and composite strains at failure were similar. A simple geometrical model is proposed, allowing prediction of the failure strain as a function of the reinforcement content, aspect ratio and strain to failure of the unreinforced matrix. The data presented are in good agreement with predictions from this model.     

Thermodynamic Modeling as a Strategy for Casting High Alloy Steels

Strategies based on thermodynamic calculations can be used to overcome the problems associated with oxides encountered in steel plant operations, which can lead to certain difficulties in the process such as clogging of submerged entry nozzle during continuous casting. Approaches to producing high alloy steels by continuous casting have been taken. One of the strategies to avoid the oxidation of chromium is to add a small amount of other elements (subject to other constraints), which do not cause subsequent problems. The problem has been studied using the Thermo-CalcR software, with related databases; and the results obtained for different process conditions or generic com-positions have been presented.     

Root resorption and pulpal changes due to intrusive force

Intrusion has been regarded as a controversial topic in the literature. It is apparent from many studies that excessive forces applied in orthodontic treatment might lead to undesirable results such as circulatory disturbances, pulp degeneration, calcification and even necrosis. This study was performed to observe the reaction of pulp and roots following tooth intrusion. Material consisted of four first premolar teeth of two adult patients. One premolar of each patient was intruded orthodontically and the other premolars were taken as controls. The palatal roots of the experimental teeth were cut and examined in scanning electron microscope (SEM) and the pulps of the teeth were examined in transmission electron microscope (TEM). At SEM examination, root surfaces of intruded teeth showed resorption cavities of different diameters and depths. At TEM examination, vascular degeneration was the main change in the pulps of experimental teeth.     

Evaluating the energetics of empty cavities and internal mutations in proteins

The energetics of cavity formation in proteins is evaluated with two different approaches and results are analyzed and compared to experimental data. In the first approach, free energy of cavity formation is extracted by RMS fitting from the distribution of numbers of cavities, N, with different volumes, Vcav, in 80 high-resolution protein structures. It is assumed that the distribution of number of cavities according to their volume follows the Boltzmann law, N(Vcav) = exp [(-a.Vcav-b)/kT], or its simplified form. Specific energy cost of cavity formation, a, extracted by RMS fitting from these distributions is compared to a values extracted from experimental free energies of cavity formation in T4 lysozyme fitted to similar expressions. It is found that fitting of both sets of data leads to similar magnitudes and uncertainties in the calculated free energy values. It is shown that Boltzmann-like distribution of cavities can be derived for a simple model of an equilibrium interconversion between mutants in an extracellular system. We, however, suggest that a partitioning into cavity-dependent and cavity-independent terms may lose meaning when one attempts to describe mutation effects on protein stability in terms of specific free energy contributions. As an alternative approach, a direct molecular mechanics evaluation is attempted of T4 lysozyme destabilization by five single cavity-creating mutations. The calculations are based on the approach used in calculations of the energetics of packing defects in crystals. For all mutations calculated destabilizations agree with the corresponding experimental values within +/-0.6 kcal/mol. A computational relaxation of the mutant was most difficult to achieve for the mutation producing the smallest cavity. However, calculations do not always reproduce crystallographically observed contraction/expansion of cavities. It is suggested that this may be related to usually observed large RMS differences (> 1 A) between crystallographic and energy-minimized protein structures, and thus correct energetics might be easier to calculate than the correct geometry.