中西医结合治疗痔疮的临床疗效观察

目的:探讨中西医结合治疗痔疮的临床疗效及复发率.方法:选择我科2009年1月至2010年2月收治的112例痔疮患者作为观察对象,将其分为中西医结合治疗组(简称治疗组)和西医治疗组(简称对照组),对两组患者的治疗效果及痔疮复发率进行比较.结果:治疗组患者痊愈率75.0%,好转率25.0%,治疗效果显著优于对照组患者,随访1年有1例复发,复发率为1.8%.对照组有4例复发,复发率为7.1%,两组患者的复发率差异无统计学意义.结论:中西医结合治疗痔疮可显著减轻患者疼痛感,无毒副作用,可达到满意的治疗效果.     

KTP脉冲激光泪道治疗机治疗睑黄瘤156例效果观察

目的 观察KTP脉冲激光泪道治疗机治疗睑黄瘤的疗效.方法 312例眼睑黄色瘤患者随机分成观察组和对照组各156例,观察组采用HGL-MYK8型KTP脉冲激光泪道治疗机治疗,对照组则采用氮低温治疗.比较两组的疗效及复发率.结果 观察组优、良、进步、无效的例数为155、0、1、0例,对照组则分别为32、22、86、16例,观察组的疗效明显优于对照组(Hc-190.05,P＜0.01).观察组的满意度为99.4%,明显高于对照组的34.6% (P＜0.01).随访6个月,对照组的复发率明显高于观察组(5.8%vs0%,P＜0.01).结论 采用HGL-MYK8型KTP脉冲激光泪道治疗机治疗睑黄瘤,医生操作技术精湛加上护理得当,可获满意效果.     

骶髂关节注射药物治疗强直性脊柱炎的临床研究

目的:观察骶髂关节注射氢化泼尼松注射液治疗强直性脊柱炎的临床疗效.方法:将57例患者随机分为治疗组29例与对照组28例,治疗组采用常规药物加骶髂关节注射氢化泼尼松注射液治疗,对照组仅采用常规药物治疗;比较两组治疗6个月后两组总体治疗效果.结果:治疗组病情改善情况优于对照组.结论:常规药物联合氢化泼尼松注射液治疗在改善强直性脊柱炎患者骶髂关节炎局部疼痛和全身功能方面较单纯常规药物治疗有着明显的优势.     

中药内服配合克霉唑栓外用治疗复发性念珠菌性阴道炎的临床观察

目的 分析观察中药内服配合克霉唑栓外用治疗复发性念珠菌性阴道炎的临床疗效.方法 将76例患者随机分为2组,治疗组36例在对照组治疗基础上加用中药自拟方治疗.对照组38例采用克霉唑栓150 mg阴道纳药治疗.结果 治疗后3～7d、4周、8周2组总有效率比较,差异均无显著性意义(P>0.05),但停药第12周后2组总有效率比较,差异均有显著性意义(P<0.05).经过12周治疗后,治疗组在随访期间复发3例,复发率为7.89%;对照组在随访期间内复发10例,复发率为26.32%,治疗组复发率低于对照组,差异有有统计学意义(P<0.05).结论 中药内服配合克霉唑栓外用治疗复发性念珠菌性阴道炎疗效确切,且能减少复发,改善临床症状,值得临床推广.     

盐酸万乃洛韦(丽珠威)联合卡介菌多糖核酸治疗复发性生殖器疹疗效观察

目的:探讨盐酸万乃洛韦联合卡介菌多糖核酸治疗复发性生殖器疱疹的疗效.方法:将48例患者随机分成两组,治疗组28例,口服盐酸万乃洛韦联合卡介菌多糖核酸肌注.对照组20例,仅口服万乃洛韦治疗.疗程均为3个月,随访一年.结果:治疗组复发率明显低于对照组(P<0.01).患者均未见明显不良反应.结论:盐酸万乃洛韦联合卡介菌多糖核酸预防生殖器疱疹复发有较好疗效,是一种安全有效的治疗方法.     

消化性溃疡患者的护理体会

目的:探讨研究规范的护理模式对消化性溃疡病人治疗的影响.方法:对40例消化性溃疡病人,随机分为对照组20例和护理组20例:对照组采用内科药物治疗.护理组在药物治疗的同时,增加服药指导、消毒、心理护理、健康教育、饮食指导等规范的护理方法.结果:护理组痊愈19例(95%),复发1例(5%);对照组痊愈15例(75%),复发5例(15%),对照组与护理组痊愈率对比,P<0.05,差异有显著性.对照组与护理组复发率对比,P<0.01,差异有显著性.结论:通过全新的规范护理能够提高疗效,减少复发.     

物理因子配合药物治疗慢性盆腔炎疗效观察

目的:观察物理因子治疗慢性盆腔炎的临床疗效.方法:将87例慢性盆腔炎患者分为2组,对照组42例单纯采用药物治疗,治疗组45例采用物理因子配合药物治疗.结果:治疗组总有效率93%,对照组40%,两组比较有非常显著性差异(p<0 01).结论:物理因子配合药物治疗慢性盆腔炎的临床疗效优于单纯采用药物治疗者.     

心理治疗焦虑症效果分析研究

焦虑症是一种常见的焦虑障碍,给患者带来难以忍受的痛苦,严重影响了患者的社会功能和生活质量.为探讨心理干预对焦虑症患者治疗和复发的预防效果,我们采用药物联合心理干预治疗进行了对照研究,现将结果报告如下.目的:探讨心理干预以及心理行为护理对焦虑症患者治疗效果以及对复发的预防效果.方法:药物治疗的基础上对焦虑症患者进行心理行为护理,将64例广泛性焦虑症患者随机分为两组,干预组31例给予药物联合心理干预治疗,对照组33例单用药物治疗.分别于入组前及治疗9 mo末采用焦虑自评量表及汉密顿焦虑量表评定临床疗效.结果:干预9 mo末,干预组焦虑自评量表及汉密顿焦虑量表评分较干预前均有极显著下降(P＜0.01),均显著低于对照组(P＜0.01);对照组焦虑自评量表评分较干预前有显著升高(P＜0.01),汉密顿焦虑量表评分无显著性差异(P＞0.05).干预组再次复发率为21.5%,对照组为47.3%,两组比较差异有极显著性(X2=9.46,P＜0.01).心理行为护理后MAMA评分(18.63±3.82)分,显著低于护理前(27.25±5.12)分(X2=7.01,P<0.01).结论:心理干预对焦虑症患者的治疗以及复发具有积极的效果:心理行为护理可改变焦虑症患者的不良认知,协调医患关系,提高患者对治疗的依从性和疗效.     

疏经活络散敷贴与熏洗联合西药治疗类风湿性关节炎临床观察

目的 观察疏经活络散熏洗与敷贴联合西药治疗类风湿关节炎的疗效.方法 将181例类风湿性关节炎患者随机分为2组,对照组91例,口服甲氨蝶呤(10mg qw)、塞来昔布(0.2g bid)、羟氯喹(0.2g bid);实验组90例,在上述治疗基础上,使用疏经活络散熏洗与敷贴,每日1次,10日1疗程,共3疗程.结果 治疗组临床疗效总有效率为94.4%,明显优于对照组的82.4%,2组差异比较有统计学意义(p<0.05).结论 疏经活络散熏洗与敷贴联合西药治疗类风湿关节炎对临床症状缓解方面具有显著作用.     

五官超短波联合音频治疗颞颌关节功能紊乱综合征

目的:探讨超短波联合音频治疗颞颌关节功能紊乱综合征的临床疗效.方法:56例患者随机分为治疗组28例和对照组28例,治疗组采用五官超短波联合音频治疗,对照组单纯采用音频治疗.结果:治疗2个疗程,观察组和对照组总有效率分别为96.4%和75%.两组疗效比较有显著性差异(p＜0.05).结论:五官超短波联合音频治疗颞颌关节功能紊乱综合征疗效明显优于单纯音频治疗.     

Regional differences in suicide in Hungary in the light of registered cases of depression

Author made a revision on the theory published by Rihmer and alii in the year 1989. According to this theory the marked regional differences of suicide in Hungary are caused by the different discovery of the "endogen depression" (rate of diagnosed depression). So the lower is the diagnosis of depression the higher is the suicide rate in a given territory. They have seen a negative correlation between the number of working physicians and the suicide rates. Author made a reexamination on a correct database between 1985-1994. He has also made a study using the DSM-III-R diagnostic criteria in four counties of Hungary. His results deny the theory above mentioned. The rank-correlation of the number of GP and the suicide rates in Hungary in years 1985-1994 did not show correlation. So the underdiagnosis of the depressive disorders and the different number of GP are not the cause of the regional differences of suicide in Hungary.     

Role of clozapine in the occurrence of chromosomal abnormalities in human bone-marrow cells in vivo and in cultured lymphocytes in vitro

Bone-marrow chromosomes were examined from 38 mentally and physically retarded and two psychiatric patients who were being treated with a variety of neuropharmacologic drugs. Twenty of these patients used clozapine (Leponex). The clastogenic effects of clozapine in vitro were studied in the lymphocyte cultures of three patients--one free of hematologic disease and two who 6 months earlier had had agranulocytosis attributed to the use of clozapine. The mean frequency of cytogenetic abnormalities in the bone-marrow cells of patients who used clozapine was significantly increased (P less than 0.05). The two patients who had had agranulocytosis had a greater frequency of cytogenetic abnormalities in their cultured lymphocytes in vivo and in vitro than the patient free of hematologic disease. A clone with a 13/14 chromosome translocation was detected in one of the patients. As all patients received a number of drugs during the in vivo and in vitro studies no definite conclusions could be drawn regarding the role played by clozapine in the occurrence of chromosomal abnormalities.     

Inhibitory effect of suramin in rat models of angiogenesis in vitro and in vivo

The aim of the present study was to test the ability of the chemotherapeutic agent suramin to inhibit angiogenesis in experimental models in vitro and in vivo. In the culture of rat aortic rings on fibronectin, suramin dose-dependently inhibited vascular cell growth, achieving the maximal effect (mean - 88% versus controls, P < 0.05) at 400 microg/ml. Image analysis showed that suramin could inhibit microvessel sprouting in fibrin from rat aortic rings as evaluated by the ratio between the cellular area and the mean gray value of the sample (sprouting index); suramin at 50 microg/ml significantly reduced the sprouting index from the control value of 0.35+/-0.04 to 0.14+/-0.02 mm2/gray level (P < 0.05). Likewise, the area occupied by cells was 19.2+/-1.8 mm2 as compared with 41.8+/-4.2 mm2 in controls (P < 0.05). In the rat model of neovascularization induced in the cornea by chemical injury, suramin at 1.6 mg/eye per day reduced the length of blood vessels (0.7+/-0.1 mm as compared with 1.5+/-0.1 mm in controls, P < 0.05). In the same model the ratio between the area of blood vessels and the total area of the cornea (area fraction score) was decreased by suramin from 0.19+/-0.02 in controls to 0.03+/-0.003 (P < 0.05). Suramin given i.p. at 30 mg/ kg per day markedly inhibited the neovascularization induced in the rat mesentery by compound 48/80 or conditioned medium from cells secreting the angiogenic protein fibroblast growth factor-3 (FGF-3). The area fraction score in control rats treated with compound 48/80 was 0.31+/-0.03, and this was reduced to 0.07+/-0.01 by suramin (P < 0.05). After i.p. administration of FGF-3 the area fraction score was reduced by suramin from 0.29+/-0.03 to 0.05+/-0.01 (P < 0.05). These results provide evidence that suramin exerts inhibitory effects on angiogenesis in both in vitro and in vivo models.     

Efficacy of lomefloxacin in treatment of nonspecific inflammatory diseases and in prophylaxis of postoperative complications in urology

Clinical and bacteriological efficacies of lomefloxacin and ofloxacin were comparatively estimated in the treatment of 104 urologic patients with nonspecific inflammatory diseases and in 36 urologic patients for prophylaxis of inflammatory complications after surgical interventions. The majority of the urinary tract pathogens i.e. Enterobacteriaceae spp. and gramnegative nonfermenting bacteria were highly susceptible to both the fluoroquinolones. The clinical and bacteriological efficacies of lomefloxacin amounted to 94.4 and 80.7 per cent and those of ofloxacin to 92 and 79.2 per cent respectively. The prophylactic use of lomefloxacin and ofloxacin was efficient in 94.7 and 94.1 per cent of the cases respectively. The antibacterial prophylaxis in urologic patients should be applied not only at the period of surgical interventions but also during the early postoperative period.     

Difference in changes of plasma volume in two types of Goldblatt hypertension in rabbits

High plasma renin concentration (PRC) and hematocrit (Ht) were observed in hypertensive rabbits with one renal artery clipped and an intact opposite kidney (Group A), while rather low PRC and Ht in hypertensive ones with one renal artery clipped and the opposite kidney removed (Group B). Plasma volume (PV), blood volume (BV), and packed cell volume (PCV) were estimated in these two types of hypertensive rabbits, and also in sham-operated rabbits (Group C). In Group A, 4 weeks after clipping of a renal artery, PV was decreased and significant inverse correlations were observed between PV and the elevation of blood pressure and between PV and PRC. A significant correlation between PRC and the elevation of blood pressure was also found 4 and 12 weeks after the clipping. PCV was increased until 12 weeks after clipping. In Group B, PV was increased 1 and 4 weeks after clipping, then returned to the initial level. Ht was decreased 1 and 12 weeks, and PCV was decreased 12 weeks after clipping. These results would indicate that a high Ht seen in Group A was partly due to the decreased PV and partly due to the increased PCV, while, in Group B, a low Ht in early stage might be mainly due to the increased PV, but in the late stage, a decreased PCV appeared to play a role to lower Ht. PRC seems to be affected differently by PV in these two types of hypertension.     

PLC在高炉汽动式鼓风机监控系统的应用

鞍钢高炉15号鼓风机是VASi-9018型轴流式汽轮压缩机，通过技术改造，采用先进的电子控制技术，建成了全新的具有现代化水平的汽轮压缩机控制系统。     

Role of signal peptides in targeting of proteins in cyanobacteria

Proteins of cyanobacteria may be transported across one of two membrane systems: the typical eubacterial cell envelope (consisting of an inner membrane, periplasmic space, and an outer membrane) and the photosynthetic thylakoids. To investigate the role of signal peptides in targeting in cyanobacteria, Synechococcus sp. strain PCC 7942 was transformed with vectors carrying the chloramphenicol acetyltransferase reporter gene fused to coding sequences for one of four different signal peptides. These included signal peptides of two proteins of periplasmic space origin (one from Escherichia coli and the other from Synechococcus sp. strain PCC 7942) and two other signal peptides of proteins located in the thylakoid lumen (one from a cyanobacterium and the other from a higher plant). The location of the gene fusion products expressed in Synechococcus sp. strain PCC 7942 was determined by a chloramphenicol acetyltransferase enzyme-linked immunosorbent assay of subcellular fractions. The distribution pattern for gene fusions with periplasmic signal peptides was different from that of gene fusions with thylakoid lumen signal peptides. Primary sequence analysis revealed conserved features in the thylakoid lumen signal peptides that were absent from the periplasmic signal peptides. These results suggest the importance of the signal peptide in protein targeting in cyanobacteria and point to the presence of signal peptide features conserved between chloroplasts and cyanobacteria for targeting of proteins to the thylakoid lumen.