胡椒碱对紫杉醇自乳化给药系统口服生物利用度的影响

考察胡椒碱对紫杉醇自乳化给药系统(SEDDS)口服生物利用度的影响.首先采用伪三元相图筛选出紫杉醇SEDDS的最优处方,然后利用高效液相色谱法测定SD大鼠口服给药胡椒碱和紫杉醇SEDDS后的血浆中的药物浓度,并考察紫杉醇SEDDS的药物动力学参数.研究结果表明,将P-糖蛋白抑制剂胡椒碱SEDDS与紫杉醇SEDDS联合应用后能显著提高紫杉醇口服生物利用度(P0.01).     

羟基喜树碱自乳化传递系统的处方筛选和体外评价

筛选和制备羟基喜树碱自乳化传递系统的处方并进行体外评价.以平衡质量浓度方法考察了羟基喜树碱在不同的油相、乳化剂和助乳化剂中的质量浓度,通过三元相图辅助筛选处方的组成,采用星点设计-效应面法优化处方中各组分的比例,筛选和制备了羟基喜树碱自乳化传递系统.考察自乳化制剂的粒径、累积溶出度、自乳化速率、微乳形态及其初步稳定性等.筛选出由m(氢化玉米油)(t) m(辛酸癸酸甘油酯)=1∶1为混合油相,m(聚氧乙烯蓖麻油)(t)m(辛酸葵酸聚乙二醇甘油酯)=2∶1为混合乳化剂,二乙烯基乙二醇单乙醚为助乳化剂和羟基喜树碱组成的自乳化传递系统.所得的优化处方可自发形成均匀球状液滴,微乳平均粒径在30 nm左右且分布窄,自乳化速率在5 min以内,溶出度在60 min内达到90％以上,而且制剂稳定性良好.通过处方研究确定了最优处方,研制了羟基喜树碱自乳化传递系统.     

FeSO4微乳液的制备

选择合适的乳化剂和油相成功制备了FeSO4微乳液,并绘制了其四相伪三元相图．通过对比实验选择了乳化剂Triton X-100及油相环己烷,配制成了微乳液,并分别以硫酸亚铁溶液（以W表示）、环己烷（以O表示）、Triton X-100和正丁醇的复配乳化剂（以S＋C表示）为三相图的三个顶点绘制了伪三元相图．     

紫杉醇硅胶表面分子印迹纳米颗粒的制备

以紫杉醇为模板分子,紫杉醇上的羟基与异氰酸酯丙基三乙氧基硅烷(IPTS)反应形成共价复合物,然后和交联剂正硅酸乙酯(TEOS)通过溶胶-凝胶的方法涂覆在纳米硅胶表面上,以热裂解的方式去除模板分子后形成紫杉醇硅胶表面分子印迹纳米颗粒。通过吸附实验分析研究了紫杉醇硅胶表面分子印迹纳米颗粒的亲和性能,结果表明印迹纳米颗粒对紫杉醇有良好的亲和性。     

维生素E自乳化固体分散体的制备

采用固体分散体技术来提高维生素E的生物利用度.以自乳化辅料和载体A为载体,采用熔融法,制备维生素E自乳化固体分散体（VE-SEDS）,通过溶出度实验,考察其溶出速率,并以测定紫外吸收光谱和粒径来鉴别药物在载体中的存在状态.研究结果表明：当维生素E自乳化制剂∶载体A（w/w）=1∶8时制得的维生素E自乳化固体分散体平均粒径为44.9 nm,累计溶出百分率在5、20 min分别达到64.7%、91.1%,溶出效果明显优于VE（0%）.将维生素E制成自乳化固体分散体后,提高了维生素E自乳化制剂的稳定性,增加了维生素E在人工肠液中的溶出度.     

EuCl3-PrCl3二元系相图的研究

利用DTA测定了EuCl3-PrCl3二元系相图,发现该体系有一个异份熔化化合物EuCl3·2PrCl3,转熔点为573 ℃,EuCl358.8%(摩尔分数);低共熔点为510 ℃,EuCl375.6%(摩尔分数).同时探讨了相图的某些规律.     

Determination of paclitaxel in southern yew tree by HPLC

Paclitaxel in southern yew tree was quantitatively determined by high performance liquid chromatography (HPLC) with ODS-C18 column. A mixture of CH3OH-H2O-CH3COOH(volume ratio: 55 :44 :1) is used as mobile phase and UV detection is carried out at 227 nm, and the column temperature is 20℃. The results show that there is a good linear felationship between the area of paclitaxel and the concentration of the sample in the range 50-500 mg/L for paclitaxel. The corresponding regression equation is Y= 13 021. 7 + 1. 01 × 106X, r=0. 9990. The average recovery is 95. 3% and the relative standard deviation is 2. 08%.     

Assessment of the quasibinary HfO2-CaO system

The HfO₂-CaO quasibinary system has been evaluated thermodynamically by means of Calphad technique. On the basis of extensive and careful evaluation of published experimental results, the optimization and calculation process has been carried out using Thermo-calc, a powerful, integrated package for thermochemical treatment. With the set of the optimized thermodynamic parameters the phase relationships have been predicted, the results were in good agreement with the experimental measurements. Two sets of phase combinations have been obtained corresponding to the disputes in experiments about the ordering phenomena in the low temperature range. It has been shown that more information is required on the liquidus and ordering behavior in this system. Project supported by the National Natural Science Foundation of China Synopsis of the first author Wu Kaisheng, Doctoral student, born in July 1968, engages mainly in (1) thermodynamic assessment of ZrO₂-and HfO₂-based ceramic systems, and (2) experimental determination and thermodynamic assessment of Ni-Al-Pt superalloy system.     

Preparation of Hollow Porous HAP Microspheres as Drug Delivery Vehicles

Hollow HAP microspheres in sub-millimeter size were prepared and investigated as a drug delivery vehicle. The LCB （lithium-calcium borate） glass microspheres, which were made through flame spray process, were chosen as precursor for hollow HAP microspheres. The LCB glass microspheres reacted with phosphate buffer （K2HPO4） solution for 5 days at 37 ℃. During the reaction the Ca-P-OH compound precipitated on the surface of LCB glass microspheres and formed porous shells. Then the microspheres turned to be hollow ones with the same diameter as the glass microspheres after LCB glass run out in the chemical reaction. After heat-treated at 600 ℃ for 4 h, the Ca-P-OH compound became HAP, thus the hollow HAP microspheres were produced. The mechanism of forming hollow HAP microspheres through the chemical reaction between phosphate buffer and LCB glass was confirmed by the XRD analysis. The microstructure characteristics of the hollow, porous microspheres were observed by SEM.     

Carbon diffusion paths in Ni-Ta-C system

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