共查询到19条相似文献,搜索用时 125 毫秒
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壳聚糖接枝共聚物的应用研究 总被引:1,自引:0,他引:1
以壳聚糖与甲基丙烯酸接枝共聚物为载体,采用直接压片法制得药物非诺落芬钙的缓释片剂.测定了缓释片剂中的非诺落芬钙的体外溶出速率,用红外光谱(FT-IR)表征了缓释片剂中非诺落芬钙与接枝共聚物形成的分子间氢键. 相似文献
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以壳聚糖与甲基丙烯酸接枝共聚物为载体,采用直接压片法制得药物非诺落芬钙的缓释片剂。测定了绥释片剂中的非诺落芬钙的上溶出速率,用红外光谱(FT-IR)表征了缓释片剂中非诺落芬钙与接枝共聚物形成的分子同氢链。 相似文献
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以海藻酸钠 (SA) 和酸化凹凸棒石 (H+-ATP) 为原料,运用溶液共混法制备了一种具有优良缓释性能的复合材料,并以其为基质材料制备了双氯芬酸钠 (DS) 缓释片.利用SEM、FTIR和XRD对复合材料形貌和结构进行了表征,考察了酸改性剂浓度、H+-ATP用量和复合时间对复合材料缓释性能的影响,以获得最佳复合工艺.结果表明,当用12 mol·L-1盐酸酸化的ATP量占复合物总量60%时,复合缓释片在体外模拟肠液中缓释性能最佳.与单一海藻酸缓释片相比,复合缓释片2 h的累积释放率由42.6%下降到23.7%,有效改善了"突释"效应.释放动力学研究表明,复合缓释片的释药行为可以用Ritger-Peppas方程很好地拟合,释药速率受骨架溶蚀和药物扩散双重控制.H+-ATP的加入显著改善了海藻酸的缓释性能. 相似文献
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目的制备缓释胸腺肽口服片剂,并探讨其生物学活性及对小鼠免疫功能的影响。方法采用常规方法制备缓释胸腺肽片剂。以E-玫瑰花环试验及淋巴细胞转化试验,评价其生物学活性;免疫小鼠,以乳酸脱氢酶释放法检测小鼠NK细胞活性;巨噬细胞吞噬功能试验检测小鼠腹腔巨噬细胞的吞噬率;流式细胞仪检测T淋巴细胞亚群。结果所制备的缓释胸腺肽口服片剂,各项质量检测指标均达到《中国药典》三部(2005版)要求,其释药过程无突释和释药峰。缓释片剂组的E-玫瑰花结形成率及淋巴细胞转化率明显高于空白基质片组,且差异有显著意义;NK细胞活性、巨噬细胞吞噬率及CD3~+、CD4~+、CD4~+/CD8~+比值与空白基质片组相比,差异均有显著意义。结论缓释胸腺肽口服片剂具有良好的生物学活性,并对小鼠免疫调节功能有明显的增强作用。 相似文献
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[目的]探讨囊化壁材对吡虫啉缓释片剂缓释速率的影响。[方法]经机械搅拌、化学交联、烘干、造粒、压片等工艺措施,分别以淀粉和β-环糊精为壁材制备了2种缓释剂片剂CS(淀粉为壁材)和CD(β-环糊精为壁材)。采用温室防效、模拟土壤pH值以及片剂对番茄植株生长的影响等试验。[结果]明确了最佳施用方式为在定植时用在植株根部正下方6 cm深度范围,最适土壤pH值为7;片剂CS和CD在第90天对白粉虱防效分别为90%和64%,对煤污病防效在107 d分别为96.8%和92.7%;在相应剂量内对植株生长有明显促进作用。[结论]CS片剂较CD片剂持效期长且缓释速率慢而均匀,以淀粉作为缓释壁材较好。 相似文献
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Jian Chen Gui-Dong Huang Si-Rong Tan Jiao Guo Zheng-Quan Su 《International journal of molecular sciences》2013,14(12):24305-24319
This study aimed to research the preparation and content determination of capsaicin-chitosan microspheres (CCMS) enteric coated tablets. The core tablets were prepared with the method of wet granulation. Nine formulae were designed to determine the optimal formula of the core tablet. Eudragit L100 was used to prepare the CCMS enteric-coated tablets. The effect of enteric coated formulation variables such as content of talc (10%, 25% and 40%), plasticisers (TEC and DBS), dosage of plasticiser (10%, 20% and 30%) and coating weight (2%, 3% and 5%) were evaluated for drug release characteristics. The in vitro release was studied using 0.1 N HCl and pH 6.8 phosphate buffer. Enteric coated tablets without ruptures or swelling behaviour over 2 h in 0.1 N HCl indicated that these tablets showed acid resistance. The accumulated release rate in phosphate buffer (pH 6.8) revealed that the prepared tablets were able to sustain drug release into the intestine and a first-order release was obtained for capsaicin. This research is the first report of the preparation and content determination of CCMS enteric coated tablets. The sustained release behavior of enteric coated formulations in pH 6.8 phosphate buffer demonstrated that it would be a potential drug delivery platform for sustained delivery of gastric irritant drugs. 相似文献
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An emulsion of pioglitazone hydrochloride (drug) was prepared by mixing drug:polymer (gelatin) in different ratios of 1:0.5, 1:1, and 1:1.5 (wt/wt), respectively. These emulsions were used for the preparation of tablets of different composition. Tablet hardness increased with a decrease in concentration of polymer, while the percentage friability increased with an increase in polymer concentration in the tablet. The encapsulated tablet showed better sustained release than conventional tablets. The effect of concentration of polymer on dissolution rates of these tablets was studied using the Hixson-Crowell cube root law equation. The data obtained prove that the formulations are useful for a sustained release of pioglitazone hydrochloride, since the percentage released after 24 h was nearly 76%. The release of pioglitazone hydrochloride was influenced by the presence of polymer and different compositions of lactose. The tablet containing an emulsion of ratio 1:0.5 showed an excellent result of rate constant, better than conventional and other compositions. 相似文献
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Metformin hydrochloride, polyacrylic acid and β-cyclodextrin were taken for the preparation of spray dried sustained released micro particles in a different ratios. These sustained release micro particles were used for the preparation of tablets. Hardness of tablet increases with increase in concentration of polymer while the percentage friability decreases with increase in polymer concentration in tablet. The encapsulated drug shows better sustained release than the conventional tablet. The kinetics of the dissolution process were studied by analyzing the dissolution data using three kinetic equations—the zero-order equation, the first-order equation and the Hixson–Crowell cube root law equation. 相似文献
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《Food and Bioproducts Processing》2007,85(3):284-290
The use of casein as a novel film-forming agent, capable of functioning as a pharmaceutical tablet coat, was assessed. Diltiazem HCl core tablets were coated with casein using a pan coater and the efficacy of four different plasticizing agents (glycerol, triethyl citrate, dibutyl sebacate and oleic acid) in producing a continuous tablet-coat were evaluated. Interestingly, only those films formed using oleic acid as a plasticizing agent were capable of producing a continuous, acceptable coat. Consequently, the drug dissolution properties of casein/oleic acid film-coated tablets in pH 1.2 and pH 6.8 media were further investigated. Post-coating thermal treatment (60, 80 and 100°C) was shown to have a significant effect on the properties of the casein-oleic acid films. Diltiazem HCl drug release at pH 1.2 was found to decrease with increasing post-coating heat treatment temperature. Additionally, only coated tablets that were subjected to post-coating heat treatment at 100°C showed sustained drug release properties at pH 6.8, which may be attributed to casein cross-linking. 相似文献
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M.P. Vaidya 《Powder Technology》2011,214(3):375-381
In the present study the effect of insoluble diluents such as microcrystalline cellulose (MCC) and dibasic calcium phosphate (DCP) on the compression characteristics and release profile of sustained release tablets containing Hydroxypropylmethylcellulose (HPMC) matrices was investigated. The effect of diluents on the compression characteristics was studied using Heckel and Kawakita equations. The effect of compression forces on the release profile was also investigated. Diclofenac Sodium (DS) was used as a model drug. Tablets were prepared using wet granulation method. It was found that there is a decrease in the drug release as the concentration of these insoluble diluents is increased. From the Heckel and Kawakita analysis it was concluded that the compressed granules of formulations containing microcrystalline cellulose showed higher plastic deformation, densification and granule fragmentation as compared to DCP. Also a relationship was evaluated between the compression force and the release profile i.e. an increase in compression force causes decrease in the release rate of the drug from the formulation irrespective of change in the diluent. 相似文献