柔性生产系统在轮胎生产中的应用

简要介绍了柔性生产系统的主要内容，并根据轮胎生产经营流程的特点，介绍了柔性生产系统在轮胎生产中的应用。认为可以利用柔性生产系统增加轮胎生产的灵活性，提高生产效率、设备利用率，缩短生产周期，以满足多品种、小批量的生产方式。同时对设备负荷平衡及信息收集和控制、硬件建设、软件开发、数据基础、人员素质等方面提出了自己的建议。     

基于MES系统的复合材料制品智能化生产管理研究

为解决复合材料制品离散化生产过程中数据冗杂、生产计划变动大、文件流转效率低等实际生产问题,国内大多数制造企业引进了制造执行系统(Manufacturing Executive System, MES)。本文结合哈尔滨玻璃钢研究院有限公司车间生产现状,设计了适用于车间实际生产的MES系统管理架构,详细介绍了MES系统各个功能模块。最后通过产线验证,达到了生产管理数字化、生产过程透明化、计划管理实时可控等良好应用效果。MES系统的建立对哈尔滨玻璃钢研究院有限公司智能化生产管理具有一定指导意义,提升了企业生产管理效率,促进企业生产更加标准化、精益化、智能化。     

全球化背景下的制造业生产调度体系探讨

面对客户随机需求,制造业生产调度系统应促进生产的快速性、动态性和敏捷性。论文以制造业生产调度体系为研究对象,从生产车间调度的目标、方法、手段、资源等基本要素入手,总结了传统生产调度系统在实际生产中的问题,并概括了系统集成视角下的生产调度方法及其改进措施,介绍了不确定条件下生产调度策略及评价指标。运用系统集成的思想,探讨了供需链环境下的制造业生产调度系统模式,最终提出了生产调度系统的集成化、动态化、高效智能化、柔性化和排程可视化等发展方向。     

用沼液、腐植酸生产液体有机肥技术及前景

结合沼液腐植酸液体有机肥生产实际,阐述了工艺技术路线、主要生产设备、生产技术指标及产品质量指标,分析了经济效益和社会效益,展望了用沼液、腐植酸生产液体有机肥生产技术的发展前景。     

用沼渣生产腐殖酸型有机复合肥技术及前景

结合了沼渣生产腐殖酸型有机复合肥的生产实际,阐述了工艺技术路线、主要生产设备、生产技术指标及产品质量指标,分析了经济效益和社会效益,展望了生产技术的推广前景。     

重整装置在炼油化工业中的作用分析

从重整装置的生产特点、原料来源、产品作用、生产效益等方面阐述了其在炼油生产与化工生产中的作用，对其在汽油调合、氢气平衡、芳烃生产等石油化工业中的作用进行了分析。     

三氯乙醛的生产综述

介绍了三氯乙醛的发展历史、生产现状、物化性质、毒性防护、生产方法及应用。详细论述了三氯乙醛的生产条件优化控制、分离精制和尾气处理等。指出三氯乙醛生产的研发方向。     

丙烯腈生产技术研究进展

综述了丙烯腈生产技术现状及生产技术的新进展。着重论述了丙烷氧化法生产丙烯腈、催化剂的研制情况、生产丙烯腈的新工艺与新技术,并对我国丙烯腈的生产与消费状况进行了分析,指出了我国丙烯腈行业的发展方向和主要研究领域。     

乙醇生产中的问题与对策

乙醇生产一般具有生产过程高度连续、工艺过程复杂和系统自动化程度高且危险性大等特点。其生产操作要求十分严格,一般都具有易燃、易爆、有毒、有害和腐蚀性强等特点,这极大地增加了乙醇生产中的事故多发性。因此分析了乙醇生产中存在的问题,并阐述了具体的解决对策,展望了乙醇生产的未来发展前景。     

水合肼的生产、应用及市场前景

介绍了水合肼的生产方法、用途、国内外生产消费现状及发展前景,提出了发展我国水合肼生产的建议。     

污泥生物炭中氮硫行为及环境效应研究进展

污泥生物炭中氮硫元素含量高，其氮硫行为和环境效应对全球气候变化的影响不容忽视。以往的研究中，研究者往往以富碳生物炭作为主要研究对象，关注碳对全球气候变化的行为和功效，而对氮硫元素的作用关注不够。本文从原始污泥基本性质到其热解过程，再到生物炭的老化，逐步对污泥生物炭整个生命周期内氮硫的行为及其环境效应研究进行综述，并对未来应注重开展的研究方向进行展望，为生物炭中氮硫元素固定、释放及与之关联的环境效应和温室气体排放控制研究提供理论基础。分析表明，污泥中氮元素含量普遍高于硫元素，且热解过程中氮比硫更容易转移至气相产物。氮硫元素随热解温度的增加，在三相产物中的分配都是炭中持续减少，油中先增后减，气中一直增加。高温（＞800℃）条件下，气相中的氮含量高于固相，而硫元素则仍然主要存在于固相中。污泥生物炭老化及其环境效应研究表明，污泥生物炭氮硫元素与土壤的相互作用及其温室效应问题在今后的研究中应引起重视。     

TrkB Receptor Signalling: Implications in Neurodegenerative,Psychiatric and Proliferative Disorders

The Trk family of receptors play a wide variety of roles in physiological and disease processes in both neuronal and non-neuronal tissues. Amongst these the TrkB receptor in particular has attracted major attention due to its critical role in signalling for brain derived neurotrophic factor (BDNF), neurotrophin-3 (NT3) and neurotrophin-4 (NT4). TrkB signalling is indispensable for the survival, development and synaptic plasticity of several subtypes of neurons in the nervous system. Substantial evidence has emerged over the last decade about the involvement of aberrant TrkB signalling and its compromise in various neuropsychiatric and degenerative conditions. Unusual changes in TrkB signalling pathway have also been observed and implicated in a range of cancers. Variations in TrkB pathway have been observed in obesity and hyperphagia related disorders as well. Both BDNF and TrkB have been shown to play critical roles in the survival of retinal ganglion cells in the retina. The ability to specifically modulate TrkB signalling can be critical in various pathological scenarios associated with this pathway. In this review, we discuss the mechanisms underlying TrkB signalling, disease implications and explore plausible ameliorative or preventive approaches.     

Hepatic and Adipose Tissue Depot-Specific Changes in Lipid Metabolism in Late-Onset Obese (LOB) Rats

Transgenic Late-onset OBesity (LOB) rats slowly develop a male-specific, autosomal dominant, obesity phenotype with a specific increase in peri-renal white adipose tissue (WAT) depot and preserved insulin sensitivity (Bains et al. in Endocrinology 145:2666–2679, 2004). To better understand the remarkable phenotype of these rats, the lipid metabolism was investigated in male LOB and non-transgenic (NT) littermates. Total plasma cholesterol (C) levels were normal but total plasma triacylglycerol (TAG) (2.8-fold) and hepatic TAG content (25%) was elevated in LOB males. Plasma VLDL-C and VLDL-TAG levels were higher while plasma apoB levels were 60% lower in LOB males. Increased hepatic TAG secretion explained the increased VLDL levels in LOB males. The hepatic gene expression of FAS, SCD-1, mitochondrial (mt)GPAT, and DGAT2 was up-regulated in both old obese and young non-obese LOB rats. Lipoprotein lipase (LPL) activity in heart and epididymal white adipose tissue (WAT) was unchanged, while LPL activity was increased in peri-renal WAT (30%) and decreased in soleus muscle (40%). Moreover, FAS, SCD-1 and DGAT2 gene expression was increased in peri-renal, but not in epididymal WAT. Basal lipolysis was reduced or unchanged and β-adrenergic stimulated lipolysis was reduced in WAT from both old obese and young non-obese LOB rats. To summarize, the obese phenotype of LOB male rats is associated with increased hepatic TAG production and secretion, a shift in LPL activity from skeletal muscle to WAT, reduced lipolytic response in WAT depots and a specific increase in expression of genes responsible for fatty acid and TAG synthesis in the peri-renal depot. F. Frick and R. Hume contributed equally to this work.     

宝钢转炉钢包用耐火材料的现状及发展趋势

综述了宝钢转炉钢包用耐火材料的变化过程及使用现状 ,重点介绍了近年来宝钢在钢包耐火材料使用上的一些技术进步 ,提出了存在的问题及对策 ,展望了今后宝钢转炉钢包的发展方向。     

Molecular mechanisms of aging and immune system regulation in Drosophila

Aging is a complex process that involves the accumulation of deleterious changes resulting in overall decline in several vital functions, leading to the progressive deterioration in physiological condition of the organism and eventually causing disease and death. The immune system is the most important host-defense mechanism in humans and is also highly conserved in insects. Extensive research in vertebrates has concluded that aging of the immune function results in increased susceptibility to infectious disease and chronic inflammation. Over the years, interest has grown in studying the molecular interaction between aging and the immune response to pathogenic infections. The fruit fly Drosophila melanogaster is an excellent model system for dissecting the genetic and genomic basis of important biological processes, such as aging and the innate immune system, and deciphering parallel mechanisms in vertebrate animals. Here, we review the recent advances in the identification of key players modulating the relationship between molecular aging networks and immune signal transduction pathways in the fly. Understanding the details of the molecular events involved in aging and immune system regulation will potentially lead to the development of strategies for decreasing the impact of age-related diseases, thus improving human health and life span.     

木质素在超临界甲醇和乙醇溶剂中液化过程分析

通过研究木质素分别在超临界甲醇和乙醇溶剂中的液化过程，分析反应温度（260～340℃）及反应时间（0～120min）对木质素在两种溶剂中的转化率、生物油收率及其组分差异的影响。实验表明，木质素在超临界乙醇中的转化率及产物收率均高于甲醇。当反应温度340℃，反应时间60min，木质素在超临界乙醇中的转化率和生物油收率比在甲醇中分别提高了16.23%和11.54%，残渣收率降低了16.23%。通过GC-MS和FTIR对生物油和残渣分析，发现生物油组分中芳香族化合物相对含量较高，在甲醇和乙醇溶剂中分别达到66.13%和58.84%；随着反应时间的延长，甲醇溶剂中残渣的醚键官能团逐渐增强，而在乙醇溶剂中则先增强后减弱。分析认为在木质素降解过程中，超临界乙醇和甲醇均可产生氢自由基作为供氢体，攻击木质素及其大分子片段中的官能团，同时使液化产物中的活性片段减活，减弱重聚合反应，从而更利于芳烃产物的生成。而甲醇在液化过程中容易与木质素断键产生的苯酚中间体发生脱氢缩合反应，通过醚键聚合产生长链芳香族化合物，形成残渣，降低生物油收率。     

Physiological effects of alarm chemosignal emitted during the forced swim test

Two experiments were conducted. In the first, male rats were immersed for 25 min in fresh water or water previously swum in by another rat. Control rats were not immersed in water. Rats tested in water previously swum in by another rat were significantly less immobile than rats tested in fresh water. Water immersion resulted in significant increases in serum corticosterone, glucose, and phosphorus levels, a decrease in potassium levels, and a higher phosphorus/potassium ratio, compared to nonimmersed controls regardless of water condition. When the two water-immersed groups were compared, rats tested in previously swum water had significantly higher glucose and significantly lower potassium levels and a higher phosphorus/potassium ratio than rats tested in fresh water. Immobility times were significantly correlated with the phosphorus/potassium ratio. In the second experiment, blood gases were measured prior to testing and at 25 min after immersion in rats tested in fresh and previously swum water. Rats in soiled water hypoventilated to a significantly greater extent than rats in fresh water but did not differ significantly in blood oxygenation. These two studies demonstrate that alarm chemosignals can produce physiological effects in conspecifics.     

中国台湾的催化和催化剂的研究开发

本文重点介绍了台湾省各大学和研究院所对催化及催化剂的教学。研究与开发方面动向,相关催化方面学科带头人的研究领域和主要成果,并给出大量参考文献。     

Exosomal Cargo May Hold the Key to Improving Reproductive Outcomes in Dairy Cows

The reproductive status of dairy cows remains a challenge for dairy farmers worldwide, with impaired fertility linked to a significant reduction in herd profitability, due in part to impaired immunity, increased metabolic pressure, and longer postpartum anestrous interval (PPAI). Exosomes are nanovesicles released from a variety of cell types and end up in circulation, and carry proteins, bioactive peptides, lipids, and nucleic acids specific to the place of origin. As such, their role in health and disease has been investigated in humans and animals. This review discusses research into exosomes in the context of reproduction in dairy herds and introduces recent advances in mass-spectrometry (MS) based proteomics that have a potential to advance quantitative profiling of exosomal protein cargo in a search for early biomarkers of cattle fertility.