The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification

We describe the assembly and annotation of a chemogenomic set of protein kinase inhibitors as an open science resource for studying kinase biology. The set only includes inhibitors that show potent kinase inhibition and a narrow spectrum of activity when screened across a large panel of kinase biochemical assays. Currently, the set contains 187 inhibitors that cover 215 human kinases. The kinase chemogenomic set (KCGS), current Version 1.0, is the most highly annotated set of selective kinase inhibitors available to researchers for use in cell-based screens.     

60kt/a磷酸一铵装置设计

结合某厂６０ｋｔ／ａ 磷酸一铵（ＭＡＰ）装置设计和云南小磷铵装置生产情况,概述了国内小磷铵装置生产技术,比选确定了加压中和－ 喷雾造粒的工艺技术路线,并介绍了装置设计的技术特点。     

基于粗糙集的仿人智能控制器的设计

将粗糙集理论的基本思想引入到仿人智能控制中,提出一种新型的仿人智能控制器的设计方法。利用粗糙集算法,从人的控制行为数据中提取控制规则,由此控制规则构造出仿人智能控制器,从而实现基于粗糙集的智能控制。     

微粒群算法优化化工建模训练集

提出两种均以微粒群(PSO)算法对原始训练集随机抽样优化,再结合机器学习算法建立预测模型的PSO算法优化化工建模训练集的思路。思路1首先以模型交叉验证的均方误差函数mse最小为目标优化训练集,再通过对验证集预测,从平行运行得到的多个优化训练集中确定最优训练集用于建模。思路2借鉴提高BP神经网络泛化能力的初期终止(early stop)法,以对验证集预测的mse最小为目标优化训练集,再通过对测试集预测,从平行运行得到的多个优化训练集中确定最优训练集用于建模。通过仿真实验研究和对某炼油厂调和汽油生产数据的具体分析应用,表明本文思路可以较大幅度提高模型的预测准确性,在化工建模中具有推广应用价值。     

基于粗集理论的工业制冷装置运行参数分析

分析了粗集理论在数据挖掘中的特点,基于粗集理论对一个实际工业制冷装置的运行参数进行了实例分析。实际运行参数从该工业制冷用户的历史运行记录中采集。经过合理筛选,用粗糙集理论约简属性,将制冷压缩机能耗的影响因素由9个降至4个,简化了对压缩机能耗的研究。根据大气干球温度的逐时变化和制冷压缩机的实际运行电流,推导出运行电流与大气干球温度关系的经验公式。结果表明,采用粗集理论来分析制冷运行参数,可以挖掘出运行数据中的潜在规律。     

A practical method for predicting grinding model parameters from laboratory batch tests

The development of a set of rules, which can be used to generate the entries of a combined selection and breakage function matrix for use in grinding model applications, from laboratory batch grinding tests, is detailed, where only size distribution data on the mill feed and product are required. The method uses an optimization procedure to generate a “best” fit of the grinding function with respect to the developed set of rules and a set of batch test results at regularly spaced grinding intervals. The set of rules has been developed to provide meaningful answers with a minimum of computational effort, while not demanding modification to accepted laboratory batch grinding techniques. A set of results is presented for a series of batch grinding tests on a crushed slag feed.     

步进式胀管器设计

针对油田套管损坏严重,其中由套管缩颈引起的套损井占很大比例,是套损井修复中需要重点解决的问题,因此研制了步进式胀管整形工具。步进式胀管整形工具主要包括液压胀管器和分瓣胀管器两部分,它利用液体易于增压和远距离可控性高的特点,将液压力转化成机械力对套管进行径向扩张,并可准确控制胀头挤胀力的大小和膨胀头的角度。从而实现了缩径套管整形的目的。利用该工具方便、快捷、安全,节省作业成本,在油田套损井修复中有很大的应用潜力。     

BP神经网络在加氢裂化装置航煤性质软测量中的应用

应用Matlab软件构建单隐层BP神经网络,并对中压加氢裂化装置航煤性质进行软测量应用。以700组样本数据作为训练集,对预测航煤闪点、终馏点模型进行训练。结果表明,在152组验证数据集上模型对闪点、终馏点预测分别取得1.57 ℃和2.74 ℃的均方误差(RMSE),随之在80组测试数据集上模型取得的泛化RMSE分别为1.87 ℃和1.98 ℃。以300组样本数据作为训练集,对预测航煤密度的模型进行训练。结果表明,在100组验证集上模型RMSE为2.18 kg·m^-3,随之在70组测试数据集上的泛化RMSE为2.72 kg·m^-3。BP神经网络的泛化RMSE表明,通过合理选择特征变量和设计网络结构,单隐层BP神经网络能够满足航煤性质的工业软测量要求。     

超声波技术在列车空调机组整体清洗方面的应用

着重介绍了为清洗列车空调机组研制的超声波专用清洗设备 .该设备是在系列模拟试验的基础上制造成功的 .通过对空调机组实际清洗证明 :超声波清洗列车空调既能满足清洗效果 ,又极大程度地提高了清洗效率 .超声波技术是适于列车空调整体清洗的有效方法 .     

SCRATCH HARDNESS TESTS OF CERAMIC MATERIALS1

Three sets of standards were prepared: (1) a set of minerals according to Mohs'Scale, (2) a set of steel samples, and (3) a set of Carboloy (tungsten carbide alloy) samples. The sets of standards were compared with each other according to their scratch hardness. Specimens of ceramic materials were then measured for scratch hardness with each set of standards. The results are compared.     

高转速、无稳心搅拌装置介绍

本文介绍了一种特殊的高转速、无稳心搅拌系统，具备简洁、高效、稳定、安全的特点，经使用证明，效果良好，性能可靠，为高速搅拌及无稳心反应釜的应用提供了一条新的设计及运用的途径。     

卷径变化中的速度控制

介绍了一种自动卷径测厚系统，包括电气配置，激光传感器设定，变频器设定，以及模数模块、数模模块的设定。给出了一部分程序梯形图及控制接线图。     

600kt/a甲醇装置压缩机组的无垫铁安装及无应力配管

介绍了600kt/a甲醇装置中压缩机组的特点,论述了大型压缩机组的无垫铁安装及其无应力配管,从安装精度、选择灌浆料、如何灌浆以及如何无应力配管的角度阐述了压缩机组在安装过程中的质量控制点。     

Residual Autocorrelation Distribution in the Validation Data Set

Testing model performance on a data set other than the data set used for estimation is common practice in econometrics, technological stochastic modelling and environmetrics. In this paper, using an ARMAX model, the asymptotic distribution of the residual autocorrelations in the validation data set is given and a χ² test for overall residual incorrelation is considered.     

基于改进差别矩阵属性约简的聚合釜粗糙集-神经网络故障诊断

引言 聚氯乙烯树脂(PVC)是重要的有机合成材料,其产品具有良好的物理性能和化学性能,广泛应用于工业、建筑、农业、电力、公用事业等领域.聚合釜则是聚氯乙烯生产装置的关键设备,聚合釜能否稳定运行直接关系到整个聚氯乙烯生产装置的运行状况.     

汽动给水泵组运行特性对机组热经济性的影响

利用等效热降法定量分析了汽动给水泵运行特性对机组热经济性所产生的影响。分析结果表明,给水泵汽轮机的运行特性对机组热经济性的影响比给水泵的影响大,且主机负荷越低时,汽动给水泵和给水泵汽轮机效率对机组热经济性的影响越大。     

Identification of sequence motifs from a set of porteins with related function

The automatic identification of motifs associated with a givenfunction is an important challenge for molecular sequence analysis.A method is presented for the extraction of such patterns fromlarge sets of unaligned sequences with related but general function,for example, a set of heat shock proteins. In such a set ofproteins there can often be several subfamilies each characterizedby one or more distinct motifs. The aim is to develop computationaltools to identify these motifs. The algorithm presented locateshigh frequency words of length k with a given number of positions,r, fixed. Statistics for a binomial distribution are used toassess the significance of the words. The high-frequency wordsare clustered and highly populated clusters retained. The compositionof the clusters is displayed graphically. A set of motifs associatedwith the sequence family can automatically be extracted. Themethod is benchmarked on a set of 106 heat shock sequences anda set of 257 toxin sequences. It is shown to recover previouslyidentified motifs.     

A data set for fuzzy colour naming

In computer vision, colour naming has been posed as a fuzzy‐set problem where each colour category is modeled by a function that assigns a membership value to any given sample. However, the success in the automation of this process relies on having an appropriate psychophysical data set for this purpose. In this article we present a data set obtained from a colour‐naming experiment. In this experiment, we used a scoring method to collect a set of judgments adequate for the fuzzy modeling of the colour‐naming task. The data set is composed of 387 colour reflectances, their CIELab and Munsell values, and the corresponding judgments provided by the subjects in the experiment. These judgments are the membership values to the 11 basic colour categories proposed by Berlin and Kay (Berlin B, Kay P. Berkeley: University of California; 1969). All these data have been made available online ( http://www.cvc.uab.es/color_naming ) and, in this article we provide a wide analysis of them. To prove the suitability of the proposed scoring methodology, we have computed a set of common statistics in colour‐naming experiments, such as consensus and consistency, on our data set. The results make it possible for us to conclude the coherence of our data with previous experiments and, thus, its usefulness for the fuzzy modeling of colour naming. © 2005 Wiley Periodicals, Inc. Col Res Appl, 31, 48–56, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/col.20172     

Trans-free vanaspati containing ternary blends of palm oil-palm stearin-palm olein and palm oil-palm stearin-palm kernel olein

Four samples of trans-free vanaspati were made using palm oil-palm stearin-palm olein (PO-POs-POo) blends (set A) and another four samples (set B) using palm oil-palm stearin-palm kernel olein (PO-POs-PKOo). Palm stearin iodine value [iodine value (IV), 30] and soft palm stearin (IV, 44) were used in this study. The products were evaluated for their physical and chemical properties. It was observed that most of the vanaspati were granular (grainy) and had a shiny appearance. Chemical analyses indicated that vanaspati consisting of PO-POs-POo had higher IV (47.7–52.4) than the PO-POs-PKOo vanaspati (37.5–47.3). The higher IV demonstrated by set A samples was due to their higher content of unsaturated fatty acids, 46.0–50.0% compared to 36.6–45.0% in set B. Decreasing the amount of palm oil while increasing palm stearin in the formulations resulted in higher slip melting points and higher yield values. Eutectic interaction was observed in PO-POs-PKOo blends. The β′ crystalline form was predominent in PO-POs-POo samples (set A). One formulation in set B exhibited β crystallinity. From the differential scanning calorimetry thermograms, samples in set B showed a high peak at the low-melting region as well as a high peak at the high-melting region. In set A, the peak at the low-melting region was relatively lower.