Eye-head coordination in labyrinthine-defective humans

Eye-head coordination during saccadic gaze shifts normally relies on vestibular information. A vestibulo-saccadic reflex (VSR) is thought to reduce the eye-in-head saccade to account for current head movement, and the vestibulo-ocular reflex (VOR) stabilizes postsaccadic gaze while the head movement is still going on. Acute bilateral loss of vestibular function is known to cause overshoot of gaze saccades and postsaccadic instability. We asked how patients suffering from chronic vestibular loss adapt to this situation. Eye and head movements were recorded from six patients and six normal control subjects. Subjects tracked a random sequence of horizontal target steps, with their heads (1) fixed in primary position, (2) free to move, or (3) preadjusted to different head-to-target offsets (to provoke head movements of different amplitudes). Patients made later and smaller head movements than normals and accepted correspondingly larger eye eccentricities. Targeting accuracy, in terms of the mean of the signed gaze error, was better in patients than in normals. However, unlike in normals, the errors of patients exhibited a large scatter and included many overshoots. These overshoots cannot be attributed to the loss of VSR because they also occurred when the head was not moving and were diminished when large head movements were provoked. Patients' postsaccadic stability was, on average, almost as good as that of normals, but the individual responses again showed a large scatter. Also, there were many cases of inappropriate postsaccadic slow eye movements, e.g., in the absence of concurrent head movements, and correction saccades, e.g., although gaze was already on target. Performance in patients was affected only marginally when large head movements were provoked. Except for the larger lag of the head upon the eye, the temporal coupling of eye and head movements in patients was similar to that in normals. Our findings show that patients with chronic vestibular loss regain the ability to make functionally appropriate gaze saccades. We assume, in line with previous work, three main compensatory mechanisms: a head movement efference copy, an active cervico-ocular reflex (COR), and a preprogrammed backsliding of the eyes. However, the large trial-to-trial variability of targeting accuracy and postsaccadic stability indicates that the saccadic gaze system of patients does not regain the high precision that is observed in normals and which appears to require a vestibular head-in-space signal. Moreover, this variability also permeates their gaze performance in the absence of head movements.     

Nucleotide sequences and functional characterization of two tobacco UAG suppressor tRNA(Gln) isoacceptors and their genes

The hypothesis was tested that peak velocity of saccadic eye movements in visual motor tasks varies with variables related to energy regulation. The hypothesis is based on the cognitive-energetical performance model of Sanders. An experimental paradigm was developed in which saccadic peak velocity of task-relevant eye movements is measured while a choice reaction task is carried out. Confounding factors of saccadic amplitude and movement direction were controlled. The task was designed in such a way that in each trial subjects performed a target saccade towards an imperative stimulus and a return saccade after the manual response back to the centre of the screen. For both types of saccades the experimental variables were foreperiod duration (short versus long), knowledge of results (with versus without), postsaccadic demand (low versus high) and time on task (five 30-min intervals). In two experiments, there are main and interaction effects of the task variables on peak saccadic velocity. Return saccades are slower than target saccades, but not in the case of high postsaccadic demand. Knowledge of results increases peak saccadic velocity, but more so for return than for target saccades. Time on task leads to a decrease in peak saccadic velocity, which is much stronger for return than for target saccades; furthermore this effect is more pronounced after short than after long foreperiods. Peak saccadic velocity is changed within seconds. The results support the hypothesis. Peak saccadic velocity of task related eye movements reflects energy regulation during task performance. The paradigm will be developed as a diagnostic tool in workload measurement.     

Testing and Sensitivity of a Simple Method for Predicting Urban Pollutant Loads

This paper tests a simple two-parameter regression model, based on rainfall intensity, for calculating event loads of total suspended solids, total phosphorus, and total nitrogen from urban catchments. It also examines the sensitivity of the model to its two parameters and to the rainfall time step. This was done by using large data sets collected at six urban catchments in temperate Melbourne. It was found that the two-parameter model typically explains approximately 90% of the variation in event loads at a site. The model also predicts the within-event behavior of pollutants when the flow lag time is taken into account, with R2 correlations greater than 0.6 in most cases for both loads and concentrations at a six minute time step. Despite its acknowledged correlation with flow, rainfall intensity over short time steps is shown to be the primary driver of pollutant mobilization, and provides a practical means of predicting pollutant loads by using readily available data.     

Twenty-four-hour concentration profiles of gonadotropin and estradiol (E2) in prepubertal and early pubertal girls: the diurnal rise of E2 is opposite the nocturnal rise of gonadotropin

To investigate the detailed pattern of circulating gonadotropin and estradiol (E2) concentrations around the onset of puberty, plasma gonadotropin and E2 were measured at 20-min intervals for 24 h in seven prepubertal and six early pubertal normal short girls. The hormone concentrations obtained were analyzed by Cluster pulse detection algorithm, cosinor analysis, and cross-correlation analysis. All subjects showed spontaneous LH and FSH pulses, and six early pubertal girls showed spontaneous E2 pulses. Cosinor analysis revealed 24-h LH rhythms in all subjects except two early pubertal girls and 24-h FSH rhythms in all subjects except one early pubertal girl. The acrophases (clocktime for maximal value) in the 24-h rhythm of LH and FSH were both found in the late hours of sleep. All subjects except three prepubertal girls showed significant 24-h E2 rhythms. In contrast to the 24-h LH and FSH rhythms, the acrophase of the 24-h E2 rhythm was found in the daytime waking period. Cross-correlation analysis demonstrated significant positive cross-correlations between LH and E2 that were maximum at an E2 lag of 5.7-9.3 h in three of the six early pubertal girls. In conclusion, the E2 concentration profiles in girls around the onset of puberty show marked 24-h rhythm, with acrophase during the daytime waking period. There exists a 5.7- to 9.3-h time lag between LH and E2 time series, and this long time lag might correspond to the time required for aromatization for E2 synthesis.     

A methodological note on time intervals between consecutive accidents.

It is pointed out that in the theoretical distribution of time intervals between consecutive accidents, short time intervals are much more frequent than long ones." An excess of short time intervals over long intervals between accidents is not itself, therefore, evidence of accident proneness. It must be shown that the excess is greater than that given by the theoretical distribution. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Ubiquitin-immunohistochemical investigation of atypical Pick''s disease without Pick bodies

OBJECTIVE: To determine whether children between the ages of 8 and 12 years are able to reliably report internalizing symptoms over short to medium-length time intervals as measured by an objective self-report instrument of internalizing symptoms. METHOD: The Internalizing Symptoms Scale for Children (ISSC) was group-administered initially to 131 children and at subsequent intervals of 2 weeks, 4 weeks, and 12 weeks. RESULTS: Pearson product-moment correlations for the ISSC total scores of the participants were computed across the various retest intervals. At 2 weeks, the correlation was .84. At 4 weeks, the correlation was .76. After 12 weeks, the correlation was .74. CONCLUSIONS: These data indicate that children between 8 and 12 years old can reliably report their experience over short to medium-length intervals. These findings provide strong support for the ISSC as a research and clinical instrument for the assessment of internalizing symptoms in children between 8 and 12 years of age, which may ultimately prove beneficial in the identification and treatment of childhood internalizing disorders. Limitations and recommendations for future research are discussed.     

Development of Interlimb Movement Synchrony in the Rat Fetus.

In the fetal rat, interlimb synchrony is a prominent form of temporally organized spontaneous motor activity in which movement of different limbs occurs at nearly the same instant. In the present study, synchrony profiles were created for different pairwise combinations of limbs over the last 5 days of gestation. Observed rates of synchrony differentiated from randomized time series from Gestational Day 19 to Day 21 (E19-E21), with forelimb synchrony emerging earlier than that of other limb pairs. Synchrony profiles were elevated at the shortest intervals between successive limb movements, indicating that movements became more tightly coupled toward the end of gestation. Interlimb synchrony appears to be a robust method of quantifying fetal movement and may prove useful as a tool for assessing prenatal nervous system functioning. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

轴类零件键槽对称度快速检测专用量具

测量轴类零件键槽对称度时,在游标卡尺的游标外测量爪内侧加装一把测量尺,使外测量爪一长一短,在不破坏原游标卡尺精度的情况下组装出的结构简单、精度高、拆装方便、测量快速的这种测量工具,解决了轴键槽对称度无法直接测量的难题,提高了工效。     

The Impact of Job Complexity and Performance Measurement on the Temporal Consistency, Stability, and Test-Retest Reliability of Employee Job Performance Ratings.

Although research has shown that individual job performance changes over time, the extent of such changes is unknown. In this article, the authors define and distinguish between the concepts of temporal consistency, stability, and test-retest reliability when considering individual job performance ratings over time. Furthermore, the authors examine measurement type (i.e., subjective and objective measures) and job complexity in relation to temporal consistency, stability, and test-retest reliability. On the basis of meta-analytic results, the authors found that the test-retest reliability of these ratings ranged from .83 for subjective measures in low-complexity jobs to .50 for objective measures in high-complexity jobs. The stability of these ratings over a 1-year time lag ranged from .85 to .67. The analyses also reveal that correlations between performance measures decreased as the time interval between performance measurements increased, but the estimates approached values greater than zero. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The coupled oscillator model of between-hand coordination in alternate-hand tapping: A reappraisal.

Single and alternating hand tapping were compared to test the hypothesis that coordination during rhythmic movements is mediated by the control of specific time intervals. In Experiment 1, an auditory metronome was used to indicate a set of timing patterns in which a 1-s interval was divided into 2 subintervals. Performance, measured in terms of the deviation from the target patterns and variability, was similar under conditions in which the finger taps were made with 1 hand or alternated between the 2 hands. In Experiment 2, the modality of the metronome (auditory or visual) was found to influence the manner in which the produced intervals deviated from the target patterns. These results challenge the notion that bimanual coordination emerges from coupling constraints intrinsic to the 2-hand system. They are in accord with a framework that emphasizes the control of specific time intervals to form a series of well-defined motor events. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

A method of signal processing in motion analysis of the trotting horse

The aim of this paper is to present a method of signal processing necessary for motion analysis in the trotting horse. Motion analysis is widely used to assess lameness in horses. By definition, lameness in trot is present if the movements during the stance phases of both fore or hind limbs differ. The motion of the horse is recorded using a system for motion analysis (Selcom, 1983, SELSPOT II User Manual, Pad Nr. 6710) and the vertical motion of the head during both stance phases is compared. The symmetry is analyzed comparing the values of the Fourier coefficients. Additional head movements are 'single events' and present a problem. In this article we propose a mode of data processing using a system matched filter that neglects the nonperiodic additional movements and allows calculation of the representative Fourier coefficients. In comparison with a filtering method previously used in motion analysis this method is proved to be advantageous, as the precision of symmetry comparison increases.     

Impairments of movement kinematics in patients with Huntington's disease: a comparison with and without a concurrent task

This study aimed to quantify the efficiency and smoothness of voluntary movement in Huntington's disease (HD) by the use of a graphics tablet that permits analysis of movements profiles. In particular, we aimed to ascertain whether a concurrent task (digit span) would affect the kinematics of goal-directed movements. Twelve patients with HD and their matched controls performed 12 vertical zig-zag movements, with both left and right hands (with and without the concurrent task), to large or small circular targets over long or short extents. The concurrent task was associated with shorter movement times and reduced right-hand superiority. Patients with HD were overall slower, especially, with long strokes, and had similar peak velocities for both small and large targets, so that controls could better accommodate differences in target size. Patients with HD spent more time decelerating, especially with small targets, whereas controls allocated more nearly equal proportions of time to the acceleration and deceleration phases of movement, especially with large targets. Short strokes were generally less force inefficient than were long strokes, especially so for either hand in either group in the absence of the concurrent task, and for the right hand is its presence. With the concurrent task, however, the left hand's behavior changed differentially for the two groups; for patients with HD, it became more force efficient with short strokes and even less efficient with long strokes, whereas for controls, it became more efficient with long strokes. Controls may be able to divert attention away from the inferior left hand, increasing its automaticity, whereas patients with HD, because of disease, may be forced to engage even further online visual control under the demands of a concurrent task. Patients with HD may perhaps become increasingly reliant on terminal visual guidance, which indicates an impairment in constructing and refining an internal representation of the movement necessary for its effective execution. Basal ganglia dysfunction may impair the ability to use internally generated cues to guide movement.     

Eye- and head movements in freely moving rabbits

1. Eye- and head movements were recorded in unrestrained, spontaneously behaving rabbits with a new technique, based upon phase detection of signals induced in implanted coils by a rotating magnetic field. 2. Movements of the eye in space were exclusively saccadic. In the intersaccadic intervals the eyes were stabilized in space, even during vigorous head movements. Most of this stability was maintained in darkness, except for the occurrence of slow drift. 3. Many saccades were initiated while the head was stationary. They were accompanied by a similar, but slower head rotation with approximately the same amplitude. The displacement of the eye in space was a pure step without appreciable under- or over-shoot. The deviation of the eye in the head was mostly transient. 4. Other saccades were started while the head was moving and were possibly fast phases of a vestibulo-ocular reflex. The time course of the eye movement in space was identical for all saccades, whether the head was moving prior to the saccade or not. Eye movements without any head movement were not observed. 5. Saccades were mostly large (average 20-6 +/- 12-4 degrees S.D.) and never smaller than 1 degree. The relations of maximal velocity and duration to amplitude were similar to those reported for man. 6. Visual pursuit of moving objects, when elicited, was only saccadic and never smooth. 7. It is concluded that the co-ordination and dynamics of the rabbit's head- and eye movements are similar to those of primates. In the absence of foveal specilization, the eye movements are restricted to a rather global redirection of the visual field, possibly in particular of the binocular area.     

Analyzing nonverbal behavior in depression.

Describes the use of time-series notation as an objective approach to a refined analysis of nonverbal behavior in depression, using behavioral samples taken from doctor–patient interviews. The movement patterns of 13 26–67 yr old depressed patients were studied twice, first when the patients were diagnosed to be in a severely depressed state, and second, when they were judged to be nearly recovered. The movements of head, trunk, shoulders, upper arms, hands, upper legs, and feet were transcribed as a series of positions over time for the 1st 3 min of each of 26 doctor–patient interviews. Codings were obtained from video recordings, at half-second intervals, for 55 coding dimensions. Three parameters, the mobility, the complexity, and the dynamic activation of body movement, were defined and quantified on the basis of these data matrixes. Findings demonstrate that the time-series notation of nonverbal interaction offers new possibilities in the quantitative study of behavior, especially in the assessment of behavioral features of potential importance in determining diagnostic subgroup and therapeutic response. (24 ref) (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Temporal aN and aT in Earthquake Ground Motion at a Single Point

This paper describes a continued study on three-dimensional temporal characteristics of earthquake ground motions at a single point. Based on an instantaneous tangential and normal acceleration decomposition of ground acceleration trajectory, a ground motion can be partitioned into a finite sequence of staggered time intervals of acceleration and deceleration. A formulation is developed to estimate speed and angular changes over a partitioned interval in terms of rates of positive and negative tangential and normal acceleration. Based on these concepts, general ground motion properties, peak ground acceleration, peak ground velocity, and peak ground displacement are examined. Several Northridge earthquake records are studied in detail. It is found that the highest peak of ground acceleration in these records corresponds to a high peak of deceleration, and a velocity maximum often precedes the peak of acceleration.     

Micro and macro perspectives in auxology: findings and considerations upon the variability of short term and individual growth and the stability of population derived parameters

The present paper links the two most contrasting aspects of auxology, and addresses the apparent discrepancy between the variability and pulsatility of short term individual growth, and the stability of population derived parameters. When body stature is measured at monthly intervals, an irregular incremental pattern becomes obvious, with a number of large scale components such as series of prepubertal and pubertal growth spurts, seasonal influences on height gain, and influences of the psychosocial and economic background. When measurement intervals decrease, the patterns of stature increment appear even more irregular, and a number of short scale components become apparent, that are distinct from measurement error. Observations are presented that suggest growth being a pulsatile, a periodic, a saltatory, respectively a chaotic event as suggested by some recent studies in animals and in human newborns. Accurate measurements of the lower leg at intervals of 24 hours support the idea of short term growth being characterized by chaotic series of 'mini growth spurts' that occur at intervals of approximately 4-9 days. The amplitude of mini growth spurts ranges between 2 and some 10 mm, and also growth velocity of each spurt varies considerably so that one spurt needs between less than one and up to several days for completion. The very opposite of the variability of individual growth was found in populations. A meta-analysis of 40 male and 51 female European and US American growth studies revealed an almost uniform general pattern of average stature increment during the last 100 years. An additional analysis of stature variation of very large Japanese and Czechoslovakian growth surveys, with all together more than 23000000 measurements, and more than 500000 German preschool and school measurements, suggested similar uniformity in the standard deviation of stature.     

Three-dimensional organization of otolith-ocular reflexes in rhesus monkeys. I. Linear acceleration responses during off-vertical axis rotation

1. The dynamic properties of otolith-ocular reflexes elicited by sinusoidal linear acceleration along the three cardinal head axes were studied during off-vertical axis rotations in rhesus monkeys. As the head rotates in space at constant velocity about an off-vertical axis, otolith-ocular reflexes are elicited in response to the sinusoidally varying linear acceleration (gravity) components along the interaural, nasooccipital, or vertical head axis. Because the frequency of these sinusoidal stimuli is proportional to the velocity of rotation, rotation at low and moderately fast speeds allows the study of the mid-and low-frequency dynamics of these otolith-ocular reflexes. 2. Animals were rotated in complete darkness in the yaw, pitch, and roll planes at velocities ranging between 7.4 and 184 degrees/s. Accordingly, otolith-ocular reflexes (manifested as sinusoidal modulations in eye position and/or slow-phase eye velocity) were quantitatively studied for stimulus frequencies ranging between 0.02 and 0.51 Hz. During yaw and roll rotation, torsional, vertical, and horizontal slow-phase eye velocity was sinusoidally modulated as a function of head position. The amplitudes of these responses were symmetric for rotations in opposite directions. In contrast, mainly vertical slow-phase eye velocity was modulated during pitch rotation. This modulation was asymmetric for rotations in opposite direction. 3. Each of these response components in a given rotation plane could be associated with an otolith-ocular response vector whose sensitivity, temporal phase, and spatial orientation were estimated on the basis of the amplitude and phase of sinusoidal modulations during both directions of rotation. Based on this analysis, which was performed either for slow-phase eye velocity alone or for total eye excursion (including both slow and fast eye movements), two distinct response patterns were observed: 1) response vectors with pronounced dynamics and spatial/temporal properties that could be characterized as the low-frequency range of "translational" otolith-ocular reflexes; and 2) response vectors associated with an eye position modulation in phase with head position ("tilt" otolith-ocular reflexes). 4. The responses associated with two otolith-ocular vectors with pronounced dynamics consisted of horizontal eye movements evoked as a function of gravity along the interaural axis and vertical eye movements elicited as a function of gravity along the vertical head axis. Both responses were characterized by a slow-phase eye velocity sensitivity that increased three- to five-fold and large phase changes of approximately 100-180 degrees between 0.02 and 0.51 Hz. These dynamic properties could suggest nontraditional temporal processing in utriculoocular and sacculoocular pathways, possibly involving spatiotemporal otolith-ocular interactions. 5. The two otolith-ocular vectors associated with eye position responses in phase with head position (tilt otolith-ocular reflexes) consisted of torsional eye movements in response to gravity along the interaural axis, and vertical eye movements in response to gravity along the nasooccipital head axis. These otolith-ocular responses did not result from an otolithic effect on slow eye movements alone. Particularly at high frequencies (i.e., high speed rotations), saccades were responsible for most of the modulation of torsional and vertical eye position, which was relatively large (on average +/- 8-10 degrees/g) and remained independent of frequency. Such reflex dynamics can be simulated by a direct coupling of primary otolith afferent inputs to the oculomotor plant. (ABSTRACT TRUNCATED)     

Three-Dimensional Large Deformation FE Analysis of Square Footings in Two-Layered Clays

In strong over soft two-layered clays, there is a potential for the footing to experience a punch-through failure, where the footing penetrates a large distance at a short time after the initial peak resistance is reached. Three-dimensional (3D) large deformation finite-element analyses using 3D RITSS method were conducted to simulate the penetration responses of square footings in strong over soft clays. The effects of surface soil heave and soil layer interface deformation during footing penetration were studied in weightless soils. Fitted equations were proposed to express the footing capacity response against the penetration depth. Based on the fitted equations, formulas to calculate footing peak bearing factor and the corresponding penetration depth were developed. The peak footing capacity factor and the corresponding penetration depth increases with the increasing of soil layer strength ratio, relative top soil layer thickness and soil weight factor, thus the potential of punch-through failure was reduced accordingly. It was also found that the soil weight effect can be a simple surcharge based on the formula developed in the weightless soil. Design charts for the peak footing capacity factor and the corresponding penetration depth were developed.     

Grip reorganization during wrist transport: the influence of an altered aperture

Past studies have examined the coupling of reach and grasp components during prehensile movements. Many of these studies have supported the view that these components reflect the output of two parallel, though temporally coupled, motor programs. When the grip aperture is Altered prior to the onset of prehension from its usual, normally flexed position to one of maximal finger extension, our previous work has shown that the grasp component appears to reorganize itself during the reach. This reorganization, consisting of a brief closing and reopening of the grip aperture, only slightly influenced the temporal components of the wrist transport. The present experiment continues this research theme by examining the characteristics of grip aperture reorganization through the comparison of the kinematics of prehension components during movements to two different size objects under normal and Altered grip aperture conditions. It was hypothesized that if the grip reorganization is task dependent it should be related to object size. The experiment found that in the Altered grip condition reorganization did occur, as indicated by a slight closing and reopening of the aperture without influencing the transport of the wrist. The amplitude of and the time to the observed inflection point in the aperture time course were related to object size. The velocity of grip closing for the large object showed double peaks, with the first substantially smaller than the second. Moreover, for the small object, the velocity of grip aperture closing also was double peaked, but the difference between peaks was less pronounced. These changes in grip velocity suggest that the grip reorganization is related to object size. No effect of Altered aperture was observed on the transport component. For both object sizes in the Altered condition, the final peak velocity of grip aperture was statistically significantly correlated with transport time and time to peak deceleration. In contrast, such correlations were not observed for the initial peak velocity of the grip aperture. Furthermore, time to maximum grip aperture was correlated with both time to peak wrist velocity and time peak to wrist deceleration. Thus, as the reach progressed toward the object, the grip and transport components became more interdependent. The results are consistent with the notion that, when a well-practiced, coordinated act such as prehension is confronted with an Altered grip posture at the onset of the reach, the grip can be reorganized during the transport to preserve the relative timing between them. Thus these data add to the growing awareness that not only is there temporal coupling between the reach and grasp components but that these components may be integrated by higher-order control mechanism.