共查询到19条相似文献,搜索用时 701 毫秒
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通过α-萘乙酸和SOCl2在无水苯中反应制得α-萘乙酰氯,然后与硫氰酸钾反应生成α-萘乙酰基异硫氰酸酯,再与邻甲氧基苯甲酰肼进行加成反应,生成新型N,N'-萘乙酰基取代邻甲氧基苯甲酰氨基硫脲化合物,用薄层色谱法跟踪最后一步反应,确定了反应时间.产物经1H NMR、 IR和元素分析测定.生物活性试验结果表明对稻子根生长具有促进作用,对大肠杆菌和枯草杆菌无明显抑菌作用. 相似文献
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以中间体2,4-二氯-5-氟苯甲酰乙酸甲酯为原料.通过与原甲酸三乙酯进行缩合,再与氨基化合物发生亲核取代反应,制备得到8种α-(2,4-二氯-5-氟苯甲酰)-β-取代氨基丙烯酸酯衍生物,并对它们的反应活性进行了研究。 相似文献
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邻羟基苯甲酸甲酯与水合肼为原料制得邻羟基苯甲酰肼,再与芳酰氯反应,得到相应的N,N′-二酰基肼,后在POCl3作用下,脱水环化生成系列2-邻羟基苯基-5-芳基-1,3,4-(口恶)二唑化合物.通过元素分析,IR,1HNMR和MS对其结构进行了表征,并对其裂解途径进行了探讨. 相似文献
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苯并噻二唑类和苯并噻唑类化合物的合成及生物活性 总被引:1,自引:1,他引:1
合成了33个苯并噻唑和苯并噻二唑类化合物,所有新化合物经过元素分析、^1H NMR和IR确认,初步的离体生物活性结果表明:I-09、II-01、II-05、II-06、III-01、III-03和III-05的活性较好,对黄瓜灰霉病菌具有良好的抑制作用。活体抗菌诱导生物活性测定结果表明:I-04、I-07、II-09、II-13、III-02、III-071000mg/L在离体条件下对黄瓜灰霉病没有抑制作用,在活体条件下有一定的抑制作用,抑制率在55.0%-84.4%,表明具有良好的诱导抗性活性。 相似文献
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A. A. Khalil A. F. Shaaban M. M. Azab A. A. Mahmoud A. M. Metwally 《Journal of Polymer Research》2013,20(6):1-10
Polyanthranilic acid (PANA) nanofibres, nanorods, nanospheres and microspheres were synthesized by polymerization of anthranilic acid using ammonium peroxydisulfate (APS) as oxidant without hard or soft templates. Polymerization of anthranilic acid was carried out in aqueous solutions of strong (hydrochloric) and weak (acetic) acids. The influence of synthetic parameters such as oxidant, initiator, dopant acid and its concentration, redox initiator, and reaction medium on the morphology and particle size of PANA have been investigated. PANA nanofibres and nanorods were obtained via redox polymerization of anthranilic acid initiated by FeSO4 as redox initiator. PANA nanospheres and nanofibres were also obtained when used aromatic amines as initiators. When polymerization carried out in the solution of weak (acetic) acid the microsphere morphology obtained and the particle size increase with increasing the concentration of weak acid. PANA nanorods were obtained also by polymerization of anthranilic in ethanol-water mixture unlike interfacial polymerization of anthranilic acid (in chloroform-water) that give PANA microspheres. The morphology and particle size of PANA was studied by scanning electron microscope (SEM) and transmission electron microscope (TEM). The average diameter of nanostructures obtained ≤100 nm. The optical bandgap of microspheres and nanofibers polymeric products were determined using UV-vis spectroscopic technique and found to be 2.0 eV and 1.6 eV, respectively. The bandgap decreased with decreasing the particle size. IR spectrum confirmed the structure of PANA nanofibres (synthesized with FeSO4 as redox initiator) in emeraldine form. The thermal stability of polymer obtained was determined by thermal gravimetric analysis (TGA). The molecular weight was determined also by gel permeation chromatography (GPC). 相似文献
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Four weakly acidic cation exchangers have been prepared, one by the polycondensation of cold extracted commercial cashewnutshell liquid (C-CNSL) with formaldehyde and the other three by the co-condensation of C-CNSL with formaldehyde and each of the compounds gallic acid, anthranilic acid and 2-mercapto-benzothiazole. The resins have been investigated for the selective uptake of cations from external solutions of different pH. The resin prepared by polycondensation of C-CNSL and the one prepared by its co-condensation with gallic acid showed comparatively specific absorption of Fe2+ ions. 相似文献
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Lipase-catalyzed synthesis of esters of anthranilic acid was attempted by employing alcohols of carbon chainlength C1–C18 using Plackett-Burman experimental design. Of the alcohols employed, methanol, decanol, cetyl alcohol, and stearyl alcohols
showed 99.9% significance. Esterification of anthranilic acid with methanol gave the highest yield at 45.6%. This study allows
the selection of better alcohols for esterification of anthranilic acid. 相似文献
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Magnetic Fe3O4–poly(aniline‐co‐o‐anthranilic acid) nanoparticles were prepared by a novel and simple method: anthranilic acid assisted polymerization. The synthetic strategy involved two steps. First, Fe3O4 nanoparticles capped by anthranilic acid were obtained by a chemical precipitation method, and then the aniline and oxidant were added to the modified Fe3O4 nanoparticles to prepare well‐dispersed Fe3O4–poly(aniline‐co‐o‐anthranilic acid) nanoparticles. Fe3O4–poly(aniline‐co‐o‐anthranilic acid) nanoparticles exhibited a superparamagnetic behavior (i.e., no hysteresis loop) and high‐saturated magnetization (Ms = 21.5 emu/g). The structure of the composite was characterized by Fourier‐transform infrared spectra, X‐ray powder diffraction patterns, and transmission electron microscopy, which proved that the Fe3O4–poly(aniline‐co‐o‐anthranilic acid) nanoparticles were about 20 nm. Moreover, the thermal properties of the composite were evaluated by thermogravimetric analysis, and it showed excellent thermal stability. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 1666–1671, 2006 相似文献
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H Steinmetz W Zander MA Shushni R Jansen K Gerth R Dehn G Dräger A Kirschning R Müller 《Chembiochem : a European journal of chemical biology》2012,13(12):1813-1817
The antibiotic elansolid C1 (8) was isolated from Chitinophaga sancti strain FxGBF13 after fermentation in the presence of anthranilic acid. Remarkably, 8 was also obtained by addition of anthranilic acid to a crude fermentation extract containing the macrolide elansolid A2 (1*). This Michael-type conjugate addition allowed us to generate 21 new derivatives of elansolid C1 (9-29) by using various nucleophiles. Biological activities of all derivatives were evaluated against Staphylococcus aureus, Micrococcus luteus, and the mouse cell line L929. 相似文献
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Ingela Fritzson Bo Svensson Dr. Salam Al‐Karadaghi Prof. Björn Walse Dr. Ulf Wellmar Dr. Ulf J. Nilsson Prof. Dorthe da Graça Thrige Dr. Stig Jönsson Dr. 《ChemMedChem》2010,5(4):608-617
A strategy that combines virtual screening and structure‐guided selection of fragments was used to identify three unexplored classes of human DHODH inhibitor compounds: 4‐hydroxycoumarins, fenamic acids, and N‐(alkylcarbonyl)anthranilic acids. Structure‐guided selection of fragments targeting the inner subsite of the DHODH ubiquinone binding site made these findings possible with screening of fewer than 300 fragments in a DHODH assay. Fragments from the three inhibitor classes identified were subsequently chemically expanded to target an additional subsite of hydrophobic character. All three classes were found to exhibit distinct structure–activity relationships upon expansion. The novel N‐(alkylcarbonyl)anthranilic acid class shows the most promising potency against human DHODH, with IC50 values in the low nanomolar range. The structure of human DHODH in complex with an inhibitor of this class is presented. 相似文献