N-苯甲酰基-N'-芳基硫脲与铜的配合物的合成及抑菌性研究

以N-苯甲酰基-N'-芳基硫脲和氯化铜为原料,在乙醇中合成了4种未见报道的标题配合物,通过元素分析、红外、紫外及荧光光谱和循环伏安法等对配合物进行了表征,初步确定其组成为[Cu(L)2Cl2]并推测了结构。对金黄色葡萄球菌、枯草芽孢杆菌以及大肠杆菌的抑菌活性测试结果表明,合成的4种配合物均有抑菌活性,且抑菌活性强于相应的配体,其中苯环上为双甲氧基取代的配体及其与铜的配合物对金黄色葡萄球菌的抑制能力强于其他配合物和配体。实验还发现配体的抑菌活性随配体取代基推电子能力呈规律性变化,配体中推电子取代基的数目和推电子能力是影响配合物抑菌活性的主要因素。     

一种新型三氮唑及其铜配合物的合成与表征

采用两种方法首次成功合成了3-(5’-甲基-4-异噁唑基)-4-氨基-5-巯基-(4H)-1,2,4-三氮唑,并以其为配体进一步合成了铜配合物。通过1H NMR、IR等对配体和铜配合物结构进行表征确认,并测定了其抑菌活性。结果表明配体和铜配合物对枯草芽孢杆菌、大肠杆菌和金黄色葡萄球菌等菌种都有抑菌活性,而铜配合物的抑菌活性比配体更强。     

水-甲苯体系中三唑酮铜配合物的合成、表征及抑菌活性

在水-甲苯体系中,合成了三唑酮与氯化铜配合物.用元素分析、红外光谱、摩尔电导,热重分析对配合物进行了表征,并推测了配合物的结构.同时还测定了配合物和配体三唑酮的抑菌活性.结果表明:配合物具有较好的抑菌活性,其中对丝核菌的活性优于三唑酮.     

5,6-二甲基-2,3-吡嗪二甲酰胺-镍配合物的制备及其抗菌活性研究

以2,3-二甲基-5,6-二氰基吡嗪为原料,稀碱条件下不完全氧化得到配体5,6-二甲基-2,3-吡嗪二甲酰胺,再与醋酸镍在弱碱条件下合成5,6-二甲基-2,3-吡嗪二甲酰胺-镍配合物,通过红外光谱、紫外光谱、差热-热重分析对配合物进行表征。采用牛津杯法预试验及试管二倍稀释法研究配体5,6-二甲基-2,3-吡嗪二甲酰胺及其配合物的抗菌活性。结果表明5,6-二甲基-2,3-吡嗪二甲酰胺-镍配合物表现出一定的抑菌和杀菌作用,而配体没有明显的抑菌杀菌作用。     

新型稀土三元配合物抗菌性质的研究

采用抑菌圈法对各配体及2,2′-联吡啶系列稀土三元配合物对大肠杆菌的抗菌活性进行了初步研究。结果表明稀土配合物的抑菌效果明显优于单独配体的抑菌效果,所供测试的化合物的抑菌活性与其浓度正相关。稀土配合物表现出较好的抑菌作用可能是稀土盐离子、配体及溶液浓度的抑菌作用的累加所得。     

双(吡啶-2-甲醛)缩对苯二胺稀土配合物的合成及抑菌活性

在无水乙醇介质中,合成出了双(吡啶-2-甲醛)缩对苯二胺(L)Schiff碱配体和它的6个新的稀土配合物。通过元素分析、摩尔电导率的测定、红外光谱分析和差热-热重分析等表征可知,配合物类型是2∶2型(RE∶L),电解质类型为1∶2型,可能结构通式为[RE2L2(Pic)4(H2O)2](Pic)2∶nH2O(RE=La、Ce、Pr、Nd,n=0;RE=Sm、Eu,n=2),其中心离子的配位数为9。通过琼脂扩散抑菌法测定了配合物的抑菌性能,结果表明,该系列配合物对金黄色葡萄球菌、大肠杆菌和枯草杆菌具有较好的抗菌活性。     

水杨醛双Schiff碱仲胺配合物的合成及抗菌活性

本文采用分步法,首先合成了新的多齿Schiff碱仲胺配体N,N’-双(2－羟基苯甲醛仲胺基乙基)-2,6-吡啶二甲酰胺（L）,进一步合成了5个新的过渡金属配合物,再通过元素分析、红外光谱、紫外光谱及核磁共振等测试手段对配体及配合物进行了表征和合理的结构推测;并采取微量稀释法研究了它们对大肠杆菌的抑菌活性。结果表明：当配体与Co和Zn离子配位后,对大肠杆菌抑菌效果明显增强。     

5-氯水杨醛缩甘氨酸与过渡金属离子配合物的合成及性质研究

合成了5-氯水杨醛缩甘氨酸Schiff碱配体及其三种金属离子(Ni2+、Cu2+、Co2+)的Schif碱配合物.用熔点、红外光谱、紫外-可见光谱、电导率等方法对配体及配合物的组成、结构、性质进行了研究,并检测了其抑菌活性.     

铒-对甲苯磺酰组氨酸-邻菲啰啉三元配合物的合成及其抑菌活性

以对甲苯磺酰组氨酸,邻菲啰啉和氯化饵为原料合成了一种新型稀土三元固体配合物。利用配位滴定,元素分析,紫外光谱(UV),红外光谱(IR),热重分析(TG-DTG)等分析手段对配合物进行了表征,推测其结构为[Er(N-Ts-L-His)3Phen]Cl3·2H2O。通过抑菌实验对配合物及配体的抑菌活性进行了研究,初步结果表明,配合物有较好的抑菌效果,并且明显强于配体的抑菌性质。     

菲醌-甘氨酸希夫碱金属配合物的合成与性能研究

以菲醌与甘氨酸为原料合成相应甘氨酸席夫碱配体(L),与过渡金属盐反应得到两种金属配合物[Cu(L)(H_2O)_2]·2H_2O(a)、[Zn(L)(H_2O)]·2H_2O)(b),通过红外光谱、紫外光谱、元素分析等对产物进行表征,探究了配体及其金属配合物对大肠杆菌的抑菌活性。结果表明:只有在以甲醇为溶剂的情况下得到了晶体配合物;配体和配合物L、[Cu(L)(H_2O)_2]·2H_2O、[Zn(L)(H_2O)]·2H_2O对大肠杆菌都有一定的抑制作用。     

新型吡唑啉衍生物合成与抑菌活性实验研究

根据α,β-不饱和醛酮亲核加成反应原理合成化合物L{[3-(4-N,N-dimethyl-pyenyl)-5-Anthracen-9-yl]-Pyrazoline}和化合物M[3-ferroceny-5-(Anthracen-9-yl)-Pyrazoline]。利用~1H NMR和~(13)C NMR对化合物进行结构表征,通过抑菌实验研究化合物抑菌生物活性。探析新型吡唑啉衍生物对革兰氏阳性菌、革兰氏阴性菌和真菌的抑菌效果,研究其结构变化对活性的影响。结果表明,化合物L和M对典型革兰氏阳性菌和典型革兰氏阴性菌有一定的抑菌效果,对真核细胞型微生物作用不明显。通过比较两者对细菌的作用结果(抑菌圈直径的大小),化合物L的抑菌作用明显强于化合物M,化合物L吡唑啉环连接N、N-二甲基苯环可能增强了抑菌生物活性。     

Synthesis of the Bacteriostatic Poly(l-Lactide) by Using Zinc (II)[(acac)(L)H2O] (L = Aminoacid-Based Chelate Ligands) as an Effective ROP Initiator

The paper presents a synthesis of poly(l-lactide) with bacteriostatic properties. This polymer was obtained by ring-opening polymerization of the lactide initiated by selected low-toxic zinc complexes, Zn[(acac)(L)H₂O], where L represents N-(pyridin-4-ylmethylene) tryptophan or N-(2-pyridin-4-ylethylidene) phenylalanine. These complexes were obtained by reaction of Zn[(acac)₂ H₂O] and Schiff bases, the products of the condensation of amino acids and 4-pyridinecarboxaldehyde. The composition, structure, and geometry of the synthesized complexes were determined by NMR and FTIR spectroscopy, elemental analysis, and molecular modeling. Both complexes showed the geometry of a distorted trigonal bipyramid. The antibacterial and antifungal activities of both complexes were found to be much stronger than those of the primary Schiff bases. The present study showed a higher efficiency of polymerization when initiated by the obtained zinc complexes than when initiated by the zinc(II) acetylacetonate complex. The synthesized polylactide showed antibacterial properties, especially the product obtained by polymerization initiated by a zinc(II) complex with a ligand based on l-phenylalanine. The polylactide showed a particularly strong antimicrobial effect against Pseudomonas aeruginosa, Staphylococcus aureus, and Aspergillus brasiliensis. At the same time, this polymer does not exhibit fibroblast cytotoxicity.     

藤茶黄酮绿色制备纳米氧化锌及其抗氧化和抗菌性能

以藤茶黄酮为原料,采用溶液燃烧法绿色制备纳米氧化锌(Nano ZnO)粉末,并利用FTIR、XRD、SEM和EDS对所得样品进行结构分析和形貌观察;使用布兰德-威廉姆斯法、透明抑菌圈法和最小抑菌浓度法考察了绿色合成Nano ZnO的抗氧化性能和抑菌性能。结果表明,以藤茶黄酮为生物模板制备的Nano ZnO粒子为六方晶系纤锌矿结构,结晶度良好,晶粒平均尺寸约为32.7nm;该纳米材料具有良好的抗氧化活性,2.5g/L的Nano ZnO溶液对1,1-二苯基-2-三硝基苯肼自由基(DPPH·)的清除率为98.24%;藤茶黄酮绿色合成Nano ZnO对金色葡萄球菌的抑菌活性高于传统化学合成的Nano ZnO。绿色合成Nano ZnO的最小抑菌浓度为1.00 g/L,而化学合成Nano ZnO的最小抑菌浓度为1.50 g/L。     

分子筛固载西佛碱和四氢西佛碱铜配合物的合成和表征

合成了三种西佛碱H₂L(H₂L₁=双水杨醛缩丙二胺，H₂L2=双水杨醛缩环己二胺，H₂L₃=双水杨醛缩乙二胺)及相应的四氢西佛碱配体H₂［H₄］L，并与醋酸铜反应合成其铜配合物。采用自由配体法将金属铜配合物封装在Y型分子筛的超笼里，同时利用红外手段对其进行了表征。证明在环己烷氧化反应中Cu［H₄］-Y比CuL-Y具有更高的反应活性。     

Synthesis,structure characterization and study of a new molybdenum Schiff base complex as an epoxidation catalyst with very high turnover numbers

The reaction between [MoO₂(acac)₂] and an ONO type Schiff-base ligand (L = 4-bromo-2-((2-hydroxy-5-methylphenylimino)methyl)phenol) resulted a new oligomer molybdenum complex ([MoO₂(L)]_n). The oligomer complex was characterized by elemental analysis, FT-IR, ¹H and ¹³C NMR spectroscopies. A suitable single crystal of the complex was grown in DMSO and characterized by X-ray single crystal diffraction as monomer stabilized by one DMSO molecule, [MoO2L(DMSO)]. The [MoO₂(L)]_n complex was used as a catalyst in epoxidation of olefins. Besides the high activity and selectivity, very high turnover numbers were a remarkable advantage of the catalytic system.     

Flexible and asymmetric ligand in constructing coordinated complexes: synthesis, crystal structures and fluorescent characterization

Flexible and asymmetric ligand L [L = 1-((pyridin-3-yl)methyl)-1H-benzotriazole], is used as a basic backbone to construct complicated metal-organic frameworks. Two new polymers, namely, [Ag(2)(L)(2)(NO(3))(2)](n) (1) and [Ag(L)(ClO(4))](n) (2), were synthesized and characterized by X-ray structure analysis and fluorescent spectroscopy. The complex 1 gives an "S" type double helical conformation, whereas complex 2 exhibits a 1D zigzag configuration. Different anions affect the silver coordination geometry and crystal packing topology.     

Synthesis, characterization, DNA interaction and antibacterial activities of two tetranuclear cobalt(II) and nickel(II) complexes with salicylaldehyde 2-phenylquinoline-4-carboylhydrazone

Salicylaldehyde 2-phenylquinoline-4-carboylhydrazone (H₂L), and its novel tetranuclear cobalt(II), nickel(II) complexes have been synthesized and characterized. The crystal structure of (NiL)₂·[NiL(H₂O)(DMF)]₂·H₂O·DMF obtained from DMF solutions of compound 2 was determined by X-ray diffraction analysis. The DNA-binding investigation suggests that the two complexes bind to DNA via groove binding mode. The in vitro antibacterial activity of complexes against Escherichia coli, Staphylococcus aureus, Bacillus subtilis was screened and compared to the activity of the free ligand, the antibacterial activity of complex 1 is active than complex 2 which is in consistent with their DNA-binding behaviors.     

新型salamo衍生物苦味酸铜(Ⅱ)配合物的合成与表征

以丙酮为溶剂,1,3-二胺氧丙烷双缩邻香草醛(H2L)与苦味酸铜反应,制备了一种新型salamo衍生物苦味酸铜(Ⅱ)配合物,其结构经元素分析,1HNMR,IR,TG-DTA及UV表征。结果表明,新型salamo衍生物是一种四齿配体,配合物的可能结构式为[Cu4L2(pic)4(H2O)2].2CH3COCH3.2H2O。     

Synthesis, Characterisation and Anti-Fungal Activities of Some New Copper(II) Complexes of Octamethyl Tetraaza-Cyclotetradecadiene

The ligand Me(8)[14]diene, L, in its free state as well as in the dihydroperchlorate form, L.2HClO(4), coordinates copper(ll) in different salts to yield a series of [CuLX(x)] X(y)(H(2)O)(z) complexes where X = NO(3), ClO(4), NCS, Cl and Br; x and y may have values of 0 or 2 and z = 0, 1 or 2. The complex, [CuL(ClO(4))(2)].2H(2)O is found to undergo axial ligand substitution reactions with SCN(-), NO(3) and Cl(-) to give a variety of substitution derivatives: [CuL(ClO(4))(m) X(n)] where X = NCS, NO(3) and Cl; m = 0 or 1, and n = 1 or 2. The complexes .have been characterised on the basis of analytical, spectroscopic, magnetic and conductance data. The anti-fungal activities of the ligand and its complexes have been investigated against a range of phytopathogenic fungi.     

水杨醛缩对氯苯胺Co(Ⅱ)配合物的合成、表征及其荧光性质研究

以水杨醛和对氯苯胺为原料合成了水杨醛缩对氯苯胺(HL),将其作为主要配体与1,4-对苯二酚以及氯化钴(CoCl2·6H2O)反应生成了Co(Ⅱ)的配合物[Co(C6H4O2)(L)2]n,用元素分析、红外吸收光谱、紫外可见吸收光谱对其结构进行了表征,并通过荧光光谱对配体、配合物荧光发光性质进行了研究。结果表明,配体水杨...