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利用二茂铁甲醛分别与1,2-乙二胺、1,3-丙二胺和1,4-丁二胺缩合,合成了3种双二茂铁基希夫碱,进行了生物活性实验。结果表明,3种双二茂铁基希夫碱对大肠埃希氏菌和金黄色葡萄球菌均具有较好的抗菌活性,1,3-丙二胺双缩二茂铁甲醛对金黄色葡萄球菌的抑菌能力最强,生物效价为210 U/mg(与四环素盐酸盐相比较);1,4-丁二胺双缩二茂铁甲醛对大肠埃希氏菌的抑菌能力最好,生物效价为1 058 U/mg(与四环素盐酸盐相比较)。3种双二茂铁基希夫碱对大肠埃希氏菌的抑菌能力比对金黄色葡萄球菌的抑菌能力强。 相似文献
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利用丹皮酚和2,4-二硝基苯肼的缩合反应合成丹皮酚缩-2,4-二硝基苯腙,标题化合物经元素分析、红外、紫外光谱以及电喷雾质谱进行了结构表征。 相似文献
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分别以丙酮和2-丁酮为原料与硝基甲烷在二乙胺催化下反应,得到两种二硝基取代物,然后用甲酸铵催化转移氢化得2,2-二甲基-1,3-丙二胺和2-甲基-2-乙基-1,3-丙二胺。对二硝基取代物和丙二胺的合成分别进行了改进,提高了产率。并对相关反应机理进行了分析。 相似文献
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首先通过Vilismier反应得到的1,3-二苯基-5-氯-吡唑-4-甲醛与氨基硫脲反应制备了关键中间体1,3-二苯基-5-氯-吡唑-4-甲醛缩氨基硫脲.最后,经吡唑醛缩氨基硫脲中间体与7种不同的ω-溴代芳基乙酮反应合成了N-(1,3-二苯基-5-氯-吡唑-4-基)-N'-(芳基-噻唑-2-基)-甲醛腙类衍生物.利用元... 相似文献
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丹皮酚衍生物抗氧化活性研究 总被引:1,自引:0,他引:1
以丹皮酚和有机胺以及多种金属化合物为主要原料,合成11种丹皮酚衍生物。通过DPPH.分析法,研究了目标产物的抗氧化性。结果表明,目标产物有一定抗氧化活性,但清除自由基能力都比较弱。 相似文献
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Acylhydrazine derived furanyl and thienyl Schiff bases and their Cu(II) complexes have been prepared and characterized on the basis of their physical, spectral and analytical data. The preferred enolic form of the Schiff base function as a tetradentate ligand during coordination to the metal ion yielding a square planar complex. The Schiff bases and their complexes with different anions were tested for their antibacterial activity against bacterial species such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa andKlebsiella pneumonae. 相似文献
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壳聚糖与柠檬醛缩合反应产席夫碱及其抗菌活性 总被引:2,自引:0,他引:2
《化工进展》2009,28(11)
通过壳聚糖与柠檬醛在超声波振荡下反应制备了壳聚糖缩柠檬醛席夫碱.采用[L_9(3~3)]正交实验探讨了反应时间、反应温度及反应物配比对壳聚糖席夫碱缩合率和取代度的影响.最佳条件为:反应物配比n(壳聚糖):n(柠檬醛)=1:6,反应温度40~50℃,反应时间10h,壳聚糖席夫碱的缩合率可达86%,取代度为0.82.红外光谱和X射线衍射光谱结果表明产物具有壳聚糖席夫碱的结构特征.对大肠杆菌、金黄色葡萄球菌和黑曲霉的抗菌实验表明,该产物对大肠杆菌、金黄色葡萄球菌和黑曲霉的最低抑菌浓度分别为1 g/L、1 g/L和5 g/L,其抗菌活性随浓度的增加而增加,且优于壳聚糖. 相似文献
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A condensation reaction of 2-amino-1,3,4-thiadiazole with 2-pyrrolecarboxaldehyde to form tridentate NNN donor Schiff base has been performed. The prepared Schiff base was further used for the formation of metal complexes having stoichiometry [M(L)(2)]X(n), where M=Cu(II) or Zn(II), L=N-(2-pyrrolylmethylene)-2-amino-1,3,4-thiadiazole, X=SO(4) (2-), NO(3) (-), C(2)O(4) (2-) or CH(3)CO(2-) and n=1 or 2. The new compounds described here have been characterized by their physical, spectral and analytical data, and have been screened against several bacterial strains such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The antibacterial potency of the Schiff base increased upon chelation/complexation, having the same metal ion (cation) but different anions opening up a novel approach in finding new ways to fight against antibiotic resistant strains. 相似文献
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合成了3种间苯二胺水杨醛Schiff碱过渡金属配合物,其结构经UuVis、IR、元素分析、摩尔电导率测定等表征。荧光光谱表明,3种配合物都能强烈猝灭牛血清白蛋白(BSA)的内源荧光。生物活性实验表明,配合物对金黄色葡萄球菌(S.aureus)、大肠杆菌(Ecoli)、枯草芽孢杆菌(B.subtilis)、绿脓杆菌(P.aeruginosa)均有不同程度的抑茵作用,其中对大肠杆菌的抑茵活性较强。3种配合物的抑菌活性均大于配体的抑茵活性。 相似文献
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Nahid Nishat Shamim Ahmad Khan Raza Rasool Shadma Parveen 《Journal of Inorganic and Organometallic Polymers and Materials》2012,22(2):455-463
Schiff base was prepared via condensation of ethanedihydrazide with 2-hydroxy benzaldehyde and further this monomeric Schiff
base polymerize with formaldehyde and barbituric acid and form polymeric Schiff base (PLSB) ligand. The ligand and its polymer
metal complexes were characterized by using elemental analysis, IR, UV–VIS, 1HNMR, magnetic susceptibility and thermogravimetric studies. On basis of elemental analysis and spectral studies, six coordinated
geometry was assigned for Mn(II), Co(II) and Ni(II) complexes and four coordinated for Cu(II) and Zn(II) complexes. PLSB act
as a tetradentate and coordinate through the azomethine nitrogen and phenolic oxygen. The thermal behavior of these polymer
metal complexes showed that the hydrated complexes losses water molecules of hydration in the first step followed immediately
by decomposition of the anions and ligand molecules in the subsequent steps. The (PLSB) ligands and its polymer metal complexes
were screened against bacterial species Escherichia coli, Staphylococcus aureus, Bacillus subtilis and fungal species Aspergillus flavus, Candida albicans, A. niger. The activity data show that the metal complexes were more potent than the parent Schiff bases. 相似文献
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利用微量肉汤稀释法测定3-对烯-1-胺(1)及其席夫碱衍生物(2a~2l)对革兰氏阳性菌金黄色葡萄球菌、革兰氏阴性菌肺炎克雷伯氏菌及真菌白色念珠菌的抑菌活性,并讨论了构效关系。结果表明:3-对烯-1-胺及其部分席夫碱衍生物对这3种菌具有一定的抑菌活性,其中化合物1对金黄色葡萄球菌的抑菌活性最强,最小抑菌浓度(MIC)值为56.25 mg/L;化合物2h和2i对肺炎克雷伯氏菌的抑菌活性最强,MIC值均为112.5 mg/L;化合物2l对白色念珠菌的抑菌活性最强,MIC值为28.125 mg/L。构效关系分析结果表明:向3-对烯-1-胺席夫碱衍生物中引入Br、Cl等卤素后,能显著增强抑菌活性;含有吡啶环的3-对烯-1-胺席夫碱衍生物对真菌白色念珠菌的抑菌活性明显要高于含呋喃环、吡咯环或噻吩环的3-对烯-1-胺席夫碱衍生物。 相似文献
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采用平板计数法研究了脱氢枞酸(1)和脱氢枞基含氮衍生物(脱氢枞胺(2)、脱氢枞酸酰胺衍生物(3a~3m)、脱氢枞胺(取代)苯甲醛Schiff碱衍生物(4a~4i))对6种病原真菌的抑制活性。结果表明:脱氢枞胺的抑菌活性优于脱氢枞酸,脱氢枞胺(取代)苯甲醛Schiff碱衍生物的抑菌活性优于脱氢枞酸酰胺衍生物。其中含卤原子的脱氢枞胺(对氯)水杨醛Schiff碱(4d)、脱氢枞胺(间氟)苯甲醛Schiff碱(4f)、脱氢枞胺(对氟)苯甲醛Schiff碱(4g)、脱氢枞胺(对氯)苯甲醛Schiff碱(4h)具有较强的抑菌活性,4h在质量浓度为180 mg/L时对灰葡萄孢、腐皮镰孢和芸苔链格孢的抑制率达100%,抑制率接近阳性对照物放线菌酮。进一步测定了脱氢枞胺(取代)苯甲醛Schiff碱衍生物4d、4f、4g和4h在不同质量浓度下对6种病原真菌的抑菌活性。结果发现4种化合物在不同质量浓度下对灰葡萄孢和芸苔链格孢均具有较好的抑制活性。化合物4f在22.5 mg/L时对6种病原真菌的抑制率最高,均大于95%,而4g在22.5 mg/L时的抑制率却最低,并且4h在45 mg/L时的抑制率较高,上述结果表明苯环上卤原子的取代位置和类型均会影响其在不同质量浓度下的抑菌活性和最佳抑菌活性的质量浓度。 相似文献
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Some acylhydrazine derived ONO donor Schiff bases and their Co(II) and Ni(II) complexes have been prepared having the same metal ion (cation) but different anions. These synthesized metal(II) complexes have been characterized on the basis of their elemental analyses, magnetic moment, molar conductance, and IR and electronic spectral data. All of the Schiff base ligands function as tridentates and the deprotonated enolic form is preferred for coordination. In order to evaluate the effect of anions on the bactericidal activity, these synthesized complexes, in comparison to the uncomplexed Schiff bases have been screened against bacterial species., Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and the results are reported. 相似文献
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通过乙酰基二茂铁与两种杂环胺(4-氨基安替比林,2-氨基-5-巯基-1,3,4-噻二唑)缩合合成了两种含二茂铁基的Schiff碱(a、b),产率分别为85.8%和72.6%,并通过IR、1HNMR及元素分析对其结构进行了确证。最后,将合成出的两种Schiff碱分别对3种细菌(金黄色葡萄球菌、大肠杆菌、枯草芽孢杆菌)进行了初步抑菌实验,将其结果与非杂环类Schiff碱Fc-C(CH3)NC6H5=(c)的抑菌性能做了比较。结果表明,Schiff碱对上述3种细菌都有抑制作用,且抑菌效果随着Schiff碱浓度的增大而增强。此外,杂环类Schiff碱(a、b)对上述3种细菌的抑菌活性明显优于非杂环类Schiff碱(c)。 相似文献
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《国际聚合物材料杂志》2012,61(4):173-177
Natural biopolymer used for hydrogels has attracted increasing attention in the multifaceted areas of biomedical science and engineering. The authors prepared chitosan biopolymer Schiff base by solvent exchange method using a simple aliphatic crosslinker, crotanaldehyde. The identity of Schiff base was confirmed by UV-vis and Fourier-transform infrared spectroscopy. The chitosan Schiff base was evaluated by XRD, TGA, DSC, and SEM. The microbiological screening results demonstrated the antibacterial activity of Schiff base against Escherichia coli and Staphylococcus aureus bacteria. These results suggest that the newly prepared Schiff base may open a new perspective in biomedical applications. 相似文献