抗菌防腐剂（Ⅱ）新型合成抗菌防腐剂（待续）

介绍了阳离子杀菌剂,羧酸（酯）类,酰胺类,植物抗病诱导剂,异噻唑啉酮类,恶唑类,咪唑类,苯（苄）胺基嘧啶类,吡咯类,嘌呤类,卤代类,无机金属类等新型合成抗菌防腐剂的化学结构,作用机理及应用等。     

抗菌防腐剂(Ⅲ) 天然抗菌防腐剂

从植物源、动物源及微生物源3个方面介绍了天然抗菌防腐剂如植物提取物、壳聚糖、抗菌肽、溶菌酶及抗生素等的发展状况.     

从使用频率看化妆品防腐剂走势(续前)

介绍了FDA的化妆品配方自愿登记计划（VCRP）及参与的好处，对《化妆品与盥洗用品》杂志公布的近30年来的的化妆品防腐剂使用频率数据进行了整理，描述了历次统计前20位品种的变迁，对一些重要品种，如重氮咪唑烷基脲、咪唑烷基脲、二羟甲基二甲基乙内酰脲、甲醛类、季铵盐-15、布罗波尔、异噻唑啉酮类、碘代丙炔基于基氨基甲酸酯（IPBC）、三氯生、苯氧乙醇和尼泊金酯类等的走势和应用进行了介绍。     

从使用频率看化妆品防腐剂走势(待续)

介绍了FDA的化妆品配方自愿登记计划（VCRP）及参与的好处，对《化妆品与盥洗用品》杂志公布的近30年来的的化妆品防腐剂使用频率数据进行了整理，描述了历次统计前20位品种的变迁，对一些重要品种，如重氮咪唑烷基脲、咪唑烷基脲、二羟甲基二甲基乙内酰脲、甲醛类、季铵盐-15、布罗波尔、异噻唑啉酮类、碘代丙炔基丁基氨基甲酸酯（IPBC）、三氯生、苯氧乙醇和尼泊金酯类等的走势和应用进行了介绍。     

抗菌防腐剂（Ⅰ）—抗菌防腐剂的历史、定义与分类

简要回顾了抗菌防腐剂的发展历程,进一步明确了杀菌剂,抑菌剂,抗菌剂,防腐剂,防霉剂,消毒剂,杀生剂,保鲜剂,抗生素的概念。同时,结合抗菌防腐剂的发展在对抗菌防腐剂按无机物,有机物和天然物分类的基础上,进一步又按化学结构和官能团将抗菌剂分为有机金属,有机卤代物,醇,酚,醚,醛,酮,醌,酸,酯,含氮类,含硫类,有机磷,有机砷类以及杂环类等。     

表面活性剂与防腐剂的相互作用效果研究

通过防腐挑战测试方法对市面上常用的3类表面活性剂（癸基葡糖苷（APG）、脂肪醇聚氧乙烯醚硫 酸钠（AES）、椰油酰胺丙基甜菜碱（CAB））与3类防腐剂（尼泊金甲酯、苯甲酸钠、苯氧乙醇） 不同搭配的防腐效果进行比较。结果显示，APG和APG+CAB对3种防腐剂均有拮抗作用，AES和 APG+AES仅对尼泊金甲酯和苯氧乙醇有相同的作用效果，而CAB和CAB+AES对3种防腐剂均有 不同的作用效果；尼泊金甲酯在AES和APG+AES体系中发挥出较强的防腐作用，苯甲酸钠在CAB 体系中防腐作用最强，而苯氧乙醇仅在AES和APG+AES体系中对细菌有很强的防腐作用。同一种 表面活性剂对不同防腐剂的作用影响都不相同，而同一种防腐剂在不同的表面活性剂中也会产生不 一样的作用效果。     

抗菌防剂（Ⅲ）天然抗菌防腐剂

从植物源、动物源及微生物源3个方面好天然抗菌防腐剂如植物提取物，壳聚糖，抗菌肽，溶菌酶及抗生素等的发展状况。     

浙江省新领域精细化工的现状及发展方向(续前)

3胶粘刘胶粘剂优点明显，应用面广、附加值高、效益好，已在社会各个领域得到应用。世界胶粘剂销售量超过1000万t，我国产量30多万t。产品牌号1000多个，可分为11类。其中木工胶（脉醒、酚醛、三聚氰胶）占30％、聚醋酸乙烯乳液占27％、聚乙烯醇为18％、聚丙烯酸酯乳液11％、氯丁胶11％、环氧树脂胶和聚氨酯胶各占1％一其它（热溶胶、厌氧胶、氰基丙烯酸酯胶、有机硅密封剂等）占l％。近年来我国有些重要产品从国外引进技术，如北京引进丙烯酸酯类、醋酸乙烯类、氰基丙烯酸酯类、食品包装用聚氨酯胶等，上海引进厌氧胶浸渍技术，江苏引进EV…     

苯醚菌酯(ZJ0712)的NMR研究

苯醚菌酯（ZJ0712）是浙江省化工研究院创制的新型甲氧基丙烯酸酯类杀菌剂。本文通过^1H、^13C及COSY，HSQC，HMBC等NMR技术对苯醚菌酯（ZJ0712）的^1H^、^13C NMR谱峰进行了全归属。     

腐植酸类化合物的仪器分析法(1)

X-射线衍射分析法是研究腐植酸中二级和三级结构的极其有效的方法，借助同时测定衍射光点强度和势能的结构参数。现已可能分析一些动、植物体内类腐植酸（生物酸）结构等。     

Photoactive antimicrobial agents/polyurethane finished leather

To prepare antimicrobial coating on leather surfaces with high potency against microbes, photoactive agents such as benzophenone (BP) and rose bengal (RB) were incorporated into polyurethane‐based coating solutions, respectively, and then the BP or RB containing solutions were applied onto surfaces of leather by a painting method. The photoactive antimicrobial agents treated leather samples were characterized by FTIR, SEM, and antimicrobial tests. The treated‐leather samples demonstrated excellent antibacterial activity under fluorescent light as well as UVA light and also the antimicrobial ability showed the effective durability to abrasion and daylight. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010     

塑料抗菌剂的研发进展

介绍了塑料抗菌剂的制备方法,综述了其研究开发进展,指出了其今后的发展趋势。     

银系抗菌剂的研发及其市场应用现状

总结了当前抗菌剂的分类，根据载体的不同，分别概述了当前不同类的银系抗菌剂的制备方法和研究现状，还报道了相关银系抗菌剂制备的专利技术，同时通过对银系抗菌剂市场的了解，对银系抗菌剂的市场应用现状作了相关报道。     

Synthesis,application and evaluation of cationising agents for cellulosic fibres

Five cationising agents were synthesised, through the reaction of various trialkylamines with epichlorohydrin, and then used for the cationisation of cellulosic fibre. The cationised cellulosic fibres could be dyed with acid dyes and showed excellent antimicrobial activity in spite of the low degree of cationisation.     

Fabrication methodologies for antimicrobial polypropylene surfaces with leachable and nonleachable antimicrobial agents

Reported herein is the fabrication of antimicrobial polypropylene (PP) surfaces with nonleachable magnesium hydroxide biocides and compares its performance with leachable copper (II) chloride dihydrate. Two methods were used for creating PP-bearing biocides. One way involves melt-blending of biocides and PP and subsequent injection molding to create the desired antimicrobial PP surface. Another technique consists of thermal embossing of antimicrobial agents on the PP surface. The biocide-bearing PP surfaces were evaluated against Escherichia coli (E. coli) K-12 MG1655) for up to 24 h. In the case of injection-molded PP system, leachable CuCl₂·2H₂O showed a 5.87 ± 0.01 log reduction after 24 h, but only 0.47 ± 0.03 log reduction for PP bearing nonleachable Mg(OH)₂. On the contrary, thermally embossed PP with CuCl₂·2H₂O and Mg(OH)₂ showed 2.28 ± 0.03 and 3.78 ± 0.03 log reductions, respectively, after 24 h. The nonleachable Mg(OH)₂ imparted antimicrobial properties only to the PP surface prepared via thermal embossing. In contrast, owning to the leachable copper ions, leachable CuCl₂·2H₂O biocides imparted PP surfaces antimicrobial irrespective of the molding or surface embossing approach. This approach provides an advantage for nonleachable PP-based antimicrobial surfaces in overcoming the toxicity concern associated with plastics bearing leachable biocides.     

The antibacterial and physicochemical properties of a one-step dental adhesive modified with potential antimicrobial agents

This study investigated the effect of antimicrobial agents on the antibacterial potential of a one-step dental adhesive. Zinc silicate microparticles (ZnSi), silver microparticles (Ag), or essential oil of tea tree (terpinen-4-ol, Tr) were added at 0.5 wt% or 1 wt%. Additional analysis included pH, degree of C=C conversion (DC), translucency parameter (TP), water sorption/solubility (W_SR/SL), morphology of bonded interfaces, and dentin microtensile bond strengths (µTBS) after 24 h or 6 months. Antibacterial potential was assessed using a microcosm biofilm model. Data were statistically analyzed at α=0.05. DC, W_SR/SL, and bonding morphology were not affected by antimicrobial incorporation. ZnSi and Ag increased pH and improved immediate µTBS, generating more stable dentin bonds after 6 months. Tr showed the poorest results for µTBS. Ag 1% was the adhesive with lower TP. In general the best antibiofouling results were observed for Ag 0.5 wt%, although all antibacterial agents showed some antibiofouling effect.     

Electrospun nanofibers of a degradable poly(ester amide). Scaffolds loaded with antimicrobial agents

Electrospinning conditions were evaluated to prepare micro/nanofibers of a biodegradable poly(ester amide) constituted by L-alanine, 1,12-dodecanediol and sebacic acid. 1,1,1,3,3,3-Hexafluroroisopropanol appeared as the most appropriate solvent to obtain fibers in a wide range of electrospinning conditions that allowed tuning the final diameter size. Fiber diameter increased with the flow, distance between the needle tip and the collector and decreasing voltage, which made it possible to obtain homogeneous fibers in the 1700–320 nm range. Fibers were loaded with antimicrobial agents like silver and chlorohexidine, and the influence of agent concentration in the electrospinning solutions on the fiber diameter size was determined. The polymer was able to crystallize during the electrospinning process, giving rise to a structure slightly different from that obtained by solution crystallization and related to that attained after crystallization from the melt state. Addition of antimicrobial agents had little effect on the degree of crystallinity, although it decreased slightly when chlorhexidine was employed. Scaffolds prepared from the silver and chlorhexidine loaded samples supported cell adhesion and proliferation. Furthermore, a clear and well differentiated antimicrobial effect against both Gram-positive (e.g. M. luteus) and Gram-negative (e.g. E. coli) bacteria was demonstrated.     

Synthesis of 2-mercaptobenzothiazole and 2-mercaptobenzimidazole derivatives condensed with carbohydrates as a potential antimicrobial agents

The thiazole and imidazole nucleus, as well as carbohydrates are important classes of compounds found in many natural and synthetic products with a wide range of biological activities. Due to the importance of these classes of compounds as antimicrobial agents, the present article reports the synthesis of a new series of nine compounds based on the coupling of 2-mercaptobenzothiazole and 2-mercaptobenzimidazole with different carbohydrates.     

Effects of antimicrobial agents on the processing and performance properties of rubber material formulations with no cytotoxicity

The present work aims to develop antimicrobial rubber for safe industrial toys. For this purpose, natural rubber (NR) and synthetic rubber as styrene butadiene rubber (SBR) and ethylene propylene diene monomer (EPDM) were examined. Rubber and their ingredients as well as antimicrobial agents (doxycycline and cephalexin) were mixed in a rubber mixer. The rheological properties of compounded rubber were studied, and the curing time was determined. Mechanical properties and cytotoxicity were evaluated at optimally cured rubber compounds. Scanning electron micrographs of vulcanizates showed good dispersion of ingredients throughout the investigated matrices. Rheology study for the investigated vulcanizates in presence of tested antimicrobial species exhibited no significant change in their flow behaviors. It is significant to remember that the desired physical characteristics of rubber products, including their chemical and mechanical characteristics (elongation at break and tensile strength) enhanced when doxycycline and cephalexin are present, depending on their nature and concentration. Similar results were obtained for both the SBR and EPDM rubber vulcanizates. The cytotoxicity of the prepared vulcanizates towards human normal retina cell line (RPI-1) indicated good safety of these rubber products. Furthermore, developed rubber vulcanizates showed good antimicrobial efficacy towards the test bacteria and fungi strains.”