温热疗法热种子材料研究进展

癌症是人类面临的一大医学难题,作为一种有效的治癌新方法--温热疗法正成为国内外研究的热点.介绍了温热疗法的原理及近年来温热疗法治癌热种子材料的研究现状.铁磁性微晶玻璃由于既具有磁性又有生物活性,是温热疗法理想的热种子材料.目前铁磁性微晶玻璃的单位质量饱和磁矩达到了32emu/g,展望了温热疗法治癌热种子材料的研究进展.     

壳聚糖作为药物缓释材料的研究进展

壳聚糖是几丁质的脱乙酰基衍生物。它具有生物相溶性好、低毒性、生物可降解性及可被吸收利用等特点，因此是一种良好的药物释放载体。综述了壳聚糖微球、壳聚糖纳米粒子、壳聚糖膜和壳聚糖水性凝胶的制备方法，药物缓释效果及其在临床上的应用。     

高分子药物缓释材料

本文首先介绍了高分子药物缓释材料的分类，然后着重叙述了两类热敏性药物缓释材料的研究概况及性能特点，最后讨论了药物缓释过程的理论研究。     

羧甲基壳聚糖在药物缓释和组织工程学中的应用新进展

羧甲基壳聚糖(CMCS)作为一种新型且具有广泛应用前景的生物聚合物在药物缓释系统、组织工程学、医用支架装置等再生医学领域的应用和研究得到了广泛的关注,作为生物聚合物材料,其在生命科学领域的应用正在迅速发展。CMCS是一种双亲性醚,它由甲壳素衍生而来,具有高水溶性、优良的生物相容性、可控的生物降解性、骨再生性等物理化学和生物特性。除此之外,CMCS还可以装载拒水性药物且展现出较强的生物活度,这使它广泛用在不同药物缓释材料系统的制备和细胞组织培养方面。本文对基于CMCS的几种新型聚合物的药物缓释特性、修复治疗特征方面做出了详细解读,并进一步简述其制备工艺和不同器官或组织的应用。文章最后指出CMCS类生物聚合物遇到的应用限制及挑战,并提出展望。     

壳聚糖作为药物缓释载体的应用及进展

壳聚糖是一种天然聚氨基葡萄糖,也是一种安全无毒、可生物降解的天然高分子,不但具有生物相容性,而且具有抗菌、止血、抑制癌细胞转移等作用,具有优良的生物降解性能和生物亲和性。简单介绍了壳聚糖的性能及作为药物缓释载体的生物学特点,并简要综述了其作为缓释载体的类型及研究应用。     

壳聚糖作为药物缓释载体的应用及进展

壳聚糖是一种天然聚氨基葡萄糖，也是一种安全无毒、可生物降解的天然高分子，不但具有生物相容性，而且具有抗茵、止血、抑制癌细胞转移等作用，具有优良的生物降解性能和生物亲和性。简单介绍了壳聚糖的性能及作为药物缓释载体的生物学特点，并简要综述了其作为缓释载体的类型及研究应用。     

聚乳酸静电纺丝纳米纤维及其药物缓释体系

聚乳酸静电纺丝纳米纤维因具有孔隙率小、比表面积大等优点,在组织工程、药物控释等领域具有广阔的应用前景。文中综述了聚乳酸纳米纤维的制备方法及其结构形貌与性能,并介绍了聚乳酸纳米纤维作为药物缓释体系的载体对药物的负载和释放的研究现状,同时对聚乳酸纳米纤维在组织工程和生物医药等领域的研究进行了展望。     

聚天冬氨酸交联温敏性水凝胶的药物缓释性能

选用牛血清蛋白(BSA)和5-氟尿嘧啶(5-FU)为模型药物,以聚天冬氨酸交联温敏性水凝胶为载体材料,采用包埋法制备了载药水凝胶,研究了水凝胶的载药和释药性能。水凝胶对BSA和5-FU的包埋率均大于98%。37℃时,水凝胶中丙烯酸用量越大,BSA的释放率越低;交联剂用量对BSA的释放率无显著影响。25℃时,丙烯酸用量越大,5-FU的释放率越大;交联剂用量越大,5-FU的释放率越小。37℃时,丙烯酸用量越小,5-FU的释放率越大;交联剂用量越大,5-FU的释放率越小。     

多孔羟基磷灰石微球的药物缓释性能

用锂钙硼（LCB）玻璃在磷酸盐溶液中的原位转化反应制备多孔羟基磷灰石（HA）微球,表征微球的物相组成、孔结构和形貌,以溶菌酶为药物模型研究了药物的缓释性能。结果表明,所制备的HA微球具有较好的孔结构。当溶菌酶溶液的浓度较低时,HA微球将溶菌酶吸附在微球的外表面;当浓度较高时,更多的溶菌酶扩散进入HA微球的微孔中,使缓释...     

新型有序介孔材料在药物传递系统中的应用

根据近10年来有序介孔材料用于药物传递系统的研究报道,综述了几种新型介孔材料的合成方法,讨论分析了药物传递系统中孔径、孔道长度、形貌和功能基团修饰等影响因素,着重阐述和评价了影响有序介孔材料结构特征的合成工艺条件,以及这些有序介孔材料潜在的药学应用价值和急需解决的问题,旨在为新型有序介孔材料在药物传递系统中的应用提供参考.     

Novel Gelatin-based Nano-gels with Coordination-induced Drug Loading for Intracellular Delivery

In this study, we develop the gelatin-dopamine(Gel-Dopa) nano-gels(GDNGs) and explore their potential as drug delivery vehicles. The Gel-Dopa precursor is synthesized using EDC/NHS coupling reaction,in which the catechols can coordinate with transition metal ions such as Fe~(3+). These novel GDNGs exhibit excellent cytocompatibility. The model drug, doxorubicin(Dox), is readily conjugated into catechol of GDNGs by the coordination cross-link of Fe~(3+) ion. The morphology and size distribution of the nanogels are characterized via field emission scanning electron microscopy and particle size analyzer, respectively.The GDNGs loaded with Dox(GDNGs-Dox) is capable of efficiently penetrating cell membrane and enter the HeL a cells. The endocytosed GDNGs-Dox release Dox molecules and subsequently kill the tumor cells.     

药用高分子材料在脉冲释药系统中的应用

传统药用高分子材料如纤维素醚类衍生物、丙烯酸树脂类及聚乙烯吡咯烷酮类等具有良好的膨胀性、溶蚀性和渗透性等。当其受到外界信号刺激时,高分子材料的结构和性质随之发生变化,从而控制药物的脉冲释放。概述了传统药用高分子材料在脉冲式药系统中的应用研究,探讨了新型高分子材料的发展方向。     

Stimulus-Responsive “Smart” Hydrogels as Novel Drug Delivery Systems

ABSTRACT

Recently, there has been a great deal of research activity in the development of stimulus-responsive polymeric hydrogels. These hydrogels are responsive to external or internal stimuli and the response can be observed through abrupt changes in the physical nature of the network. This property can be favorable in many drug delivery applications. The external stimuli can be temperature, pH, ionic strength, ultrasonic sound, electric current, etc. A majority of the literature related to the development of stimulus-responsive drug delivery systems deals with temperature-sensitive poly(N-isopropyl acrylamide)(pNIPAAm) and its various derivatives. However, acrylic-based pH-sensitive systems with weakly acidic/basic functional groups have also been widely studied. Quite recently, glucose-sensitive hydrogels that are responsive to glucose concentration have been developed to monitor the release of insulin. The present article provides a brief introduction and recent developments in the area of stimulus-responsive hydrogels, particularly those that respond to temperature and pH, and their applications in drug delivery.     

Preparation and Evaluation of Self-Microemulsifying Drug Delivery System Containing Vinpocetine

The main purpose of current investigation is to prepare a self-microemulsifying drug delivery system (SMEDDS) to enhance the oral bioavailability of vinpocetine, a poorly water-soluble drug. Suitable vehicles were screened by determining the solubility of vinpocetine in them. Certain surfactants were selected according to their emulsifying ability with different oils. Ternary phase diagrams were used to identify the efficient self-microemulsifying region and to screen the effect of surfactant/cosurfactant ratio (K_m). The optimized formulation for in vitro dissolution and bioavailability assessment was oil (ethyl oleate, 15%), surfactant (Solutol HS 15, 50%), and cosurfactant (Transcutol^® P, 35%). The release rate of vinpocetine from SMEDDS was significantly higher than that of the commercial tablet. Pharmacokinetics and bioavailability of SMEDDS were evaluated. It was found that the oral bioavailability of vinpocetine of SMEDDS was 1.72-fold higher as compared with that of the commercial tablet. These results obtained demonstrated that vinpocetine absorption was enhanced significantly by employing SMEDDS. Therefore, SMEDDS might provide an efficient way of improving oral bioavailability of poorly water-soluble drugs.     

磁流体材料在肿瘤靶向药物传递的应用研究

磁流体以其独有特性在磁靶向药物传递系统中具有较大优势,通过分析磁流体靶向药物传递载体、传递机理研究现状,指出磁流体靶向药物传递主要表现为磁场力与血液流动剪切力之间的竞争.鉴于实验研究中使用的磁场大大超过临床上使用的安全磁场并会对病人造成伤害,提出采用包括恒定磁场和梯度磁场的组合磁场来降低最大磁场强度的思路,并指出磁流体传递过程中需考虑磁流体磁粘特性,以最终降低磁场强度,减少对人体危害,推动临床应用的发展.     

Cataplasm-Based Controlled Drug Delivery: Development and Optimization of a Novel Formulation

The objective of the present study was to study the formulation variables involved in the development of a novel plasterlike preparation (cataplasm) and to optimize important formulation variables with an aim to maximize the in vitro release of the drug with minimum lag time. Cataplasm was prepared by dispersing a model drug (ibuprofen), humectant (glycerol), adhesive (Indopol H100®), polymer (Carbopol C934P®) with other formulation ingredients in a beaker with an open-blade impeller. The paste was cast on a nonocclusive backing membrane and dried overnight. The diffusion of the model drug was studied across a cellulosic membrane using Franz's diffusion cells. The amounts of three formulation variables, carbopol (X₁), glycerol (X₂), and indopol (X₃) were studied at three levels, and a face-centered cubic design was used to maximize the flux. An optimization procedure for maximum flux and minimum lag time predicted a flux of 97.22 mcg/cm²/hr at X₁ (2% w/w), X₂ (11.75% w/w), and X₃ (6% w/w). An experimental patch prepared with the above concentrations yielded a flux of 90.7 mcg/cm²/hr.     

无机材料喷墨制备新方法的进展

近年来, 喷墨制备技术被用于无机材料复杂三维结构无模成型和材料芯片的制备中, 受到了国内外研究人员的广泛关注. 本文综述了喷墨制备技术在无机材料多个方面的研究进展, 包括不同驱动模式的喷墨设备选择, 材料墨水的性能、无机材料复杂结构和材料芯片喷墨制备过程中存在的问题以及目前研究的热点问题等. 并介绍了作者在喷墨制备应用研究方面的进展, 包括电极制作和制备材料芯片用电磁式喷墨打印设备的建立.