骨胶粘合剂改性新工艺研究

研究了以环氧氯丙烷接枝共聚改性骨胶的制备工艺,通过对影响该合成工艺的各种因素如水胶比、加碱量、碱解时间等的分析,初步探讨出了一条与传统改性工艺不同的改性路线.所得到的改性骨胶粘合剂凝固点低,粘结强度高.     

Al~(3+)改性骨胶粘合材料合成机理及耐水性研究

利用Al3+对骨胶进行改性,制备了Al3+改性骨胶粘合材料(CA)。研究了Al3+对骨胶的改性机理,利用FT-IR(傅立叶转换红外)光谱,XRD(X射线衍射)光谱,PL(荧光发射)光谱,XPS(X射线衍射光电子)能谱对改性机理进行验证,通过扫描电子电镜(SEM),表面润湿角检测仪对CA进行耐水性表征。结果表明,Al3+与骨胶分子肽链中的—NH和O发生配位反应,使骨胶分子各肽链之间通过Al3+交联在一起,形成稳定的五元环网状结构;CA膜表面较骨胶膜表面更加规整、平滑、致密;表面润湿角检测发现CA膜的接触角为92.45°,而骨胶膜的接触角只有42.58°。     

响应面法优化改性碳化稻壳对铅的吸附

采用聚天冬氨酸(PASP)改性碳化稻壳作为新型生物吸附剂对水溶液中铅离子进行吸附,探讨了影响吸附效果的主要因素,并利用Box-Behnken响应面法对吸附条件进行了优化。单因素实验结果表明,溶液pH、脱除时间、吸附剂投加量对铅的吸附产生较大影响。响应面分析法对吸附条件的优化结果表明,当pH=3.5、脱除时间为40min、吸附剂投加量为0.06g时,PASP改性碳化稻壳对铅的吸附效果最好,理论脱除率可达到99.45%,与实测脱除率仅偏差3.73%。研究表明,PASP改性碳化稻壳能显著提高吸附铅的能力和效率。     

响应面法优化保水缓释肥料的合成工艺及其性能研究

以丙烯酸为聚合包裹材料,高比例添加膨润土无机添加剂,利用响应面法进行实验设计,获得氮(N)含量与各个单因素的函数关系,并建立以含氮量为响应值的保水缓释肥料合成工艺模型.通过回归方程和响应曲面分析,获得保水缓释肥料最佳合成工艺为丙烯酸中和度为59％,尿素量为37.26％,膨润土量为20％,反应时间4h.验证结果显示,在此条件下含氮量为20.56％.N素缓释行为研究表明,在蒸馏水中N的缓释机制为Fick扩散机制,且具有较好的缓释性能.盆栽试验表明,在干旱条件下,保水缓释肥料的使用在很大程度上提高了棉花的发芽率、成苗率及生物量的积累.     

响应面优化法研究果糖间苯二酚树脂胶粘剂的合成

以高果糖浆代替甲醛,在碱性条件下合成了一种绿色环保型果糖间苯二酚树脂胶粘剂。用响应面优化法对果糖间苯二酚树脂的合成条件进行了优化,以树脂黏度为考察指标,根据Box-Benhnken的中心组合实验设计原理,对实验进行设计并对结果进行了分析。研究了温度、时间和催化剂用量对反应的综合影响,得出最佳工艺条件为:反应温度61.97℃、反应时间5.24h、催化剂质量分数6.21%。在此条件下,树脂的黏度为285.523 mPa.s,测得所研制的胶粘剂的拉伸强度达到33.1 MPa。     

响应面优化法研究蔗糖苯酚树脂胶粘剂的合成

以蔗糖代替甲醛,在碱性条件下合成了一种环保型蔗糖苯酚树脂胶粘剂.用响应面优化法对蔗糖苯酚树脂的合成条件进行了优化,以树脂黏度作为考察指标,根据中心复合的设计原理对实验进行设计并对结果进行分析.研究了温度、时间、糖酚比和催化剂用量对反应的影响,得到最佳工艺条件为:反应温度95.63℃,反应时间5.26h,糖酚比2.6,催...     

丙烯酸改性酚醛环氧树脂的合成工艺研究

以三乙胺、二甲苯胺为催化剂合成了丙烯酸改性F－44酚醛环氧树脂，研究了反应时间、温度、催化剂用量对丙烯酸转化率的影响，测试了产物的光化学反应活性、力学性能，耐酸碱性、耐溶剂性等。结果表明，反应温度95℃、6h可以制得含环氧基的丙烯酸酚醛环氧树脂（AFEE）。该树脂制备的涂膜具有良好的力学性能、耐溶剂性和耐酸碱性等。光敏实验表明，AFEE树脂中的碳碳双键具有较高的光化学反应活性。     

一种环保骨胶黏合剂的合成及性能研究

以表氯醇为交联剂,采用酸解、共聚交联的方法,对传统骨胶进行了改性,制备了一种在常温下为液态的黏合剂,利用红外光谱对产物结构进行了表征。实验表明:在酸解温度为60℃,共聚交联温度为50℃,表氯醇用量为骨胶量的10%、接枝共聚时间为90min时,所得黏合剂凝固点达到-6℃,是1种使用方便的环保型黏合剂。     

梓油改性酚醛树脂的合成及结构分析

用我国湖北省产的梓油，合成了改性酚醛树脂，并对反应机理和树脂结构进行了分析。结果表明，当梓油含量不苯酚含量为３０－６０％时，改性酚醛树脂的性能最好。在改性酚醛树脂交联固化过程中所形成的ＩＰＮ结构，提高了酚醛树脂的韧性的耐热性。     

响应曲面法优化加气混凝土砂浆配方研究

以塑化剂、胶粉和纤维素醚为实验因素,利用响应曲面法进行实验设计,研究了加气混凝土抹面砂浆的配方,并对配方进行了试验验证.结果表明,砂浆的最优配比条件为塑化剂0.08%、胶粉0.75%和纤维素醚0.15%,模型达到显著水平,可以对砂浆的性能指标进行分析和预测.     

Simultaneous Optimization of Capsule and Tablet Formulation Using Response Surface Methodology

Abstract

The study described herein was undertaken to simultaneously optimize the composition of tablet and capsule formulation of an insoluble experimental drug, and to learn more about the effect of the interaction between the ingredients on the basic properties of the final dosage form. Four independent variables were varied in a set of statistically designed experiments, and a number of properties evaluated. A substantial saving in development time and quantity of drug was thereby achieved.     

Simultaneous Optimization of Capsule and Tablet Formulation Using Response Surface Methodology

The study described herein was undertaken to simultaneously optimize the composition of tablet and capsule formulation of an insoluble experimental drug, and to learn more about the effect of the interaction between the ingredients on the basic properties of the final dosage form. Four independent variables were varied in a set of statistically designed experiments, and a number of properties evaluated. A substantial saving in development time and quantity of drug was thereby achieved.     

响应曲面法优化微波干燥白炭黑研究

基于中心组合设计的响应曲面法,研究了微波干燥温度、干燥时间和白炭黑厚度及其交互作用对白炭黑相对脱水率的影响,得到了影响因素与白炭黑相对脱水率之间的二次方数学模型,获得了微波干燥白炭黑的优化工艺条件,即干燥温度90℃,干燥时间32min,物料厚度10mm,此条件下白炭黑的相对脱水率为99.68%。所得物料经粉碎,采用行业标准和激光粒度仪进行表征测试,其加热减量为1.2%,灼烧减量为49.8%,平均粒度为11μm。     

Solving Multiple Response Simulation Models Using Modified Response Surface Methodology Within A Lexicographic Goal Programming Framework

paper describes a new procedure for obtaining satisfactory solutions to multiple-response, multiple-input simulation models. A modified version of response surface methodology is incorporated to obtain input values which meet user specified goals for the responses. The approach is illustrated with three examples which demonstrate the method. The desirability of incorporating this approach into an interactive computer mode is also discussed.     

遗传算法在响应曲面拟合中的应用

响应曲面方法（RSM）是一种重要的实验设计优化方法,但是当影响因素和响应输出之间的关系异常复杂时,RSM难以拟合影响因素和响应输出之间的响应曲面.遗传算法（GAs）是一种借鉴生物界自然选择和进化发展起来的高度并行、随机、自适应搜索算法,具有强大的搜索能力.本文将遗传算法引入RSM,通过对遗传算法各参数的设计和改进,克服了传统遗传算法易局部收敛的问题.     

响应曲面法优化小桐子壳基活性炭制备条件的实验研究

采用水蒸气物理法制备小桐子壳基活性炭,通过响应曲面法中模型的优化设计和分析,研究了制备过程中的3个影响因子(活化温度、活化时间以及水蒸气流量)对活性炭碘吸附能力和得率的影响,并通过方差分析(ANOVA)研究了各个实验因子或交互作用对活性炭性能的影响。经过优化所获得的实验条件为:活化温度900℃,活化时间22min,水蒸气流量5.5g/min,获得的活性炭碘值为950mg/g,得率为13%,比表面积为785m2/g。     

基于响应面法的异型腔模具顺序注塑成型工艺参数优化

提出了基于响应面法(RSM)和有限元分析技术的顺序注塑成型(SIM)工艺参数优化方法,解决时序阀浇口设置对异型腔模具充填平衡性的影响。以阀浇口延时开启时间为设计变量,采用中心复合设计(CCD)进行试验规划,运用Moldflow有限元软件进行充填平衡性分析,并引入熵值权重法和线性加权和法对充填结束时间差和综合成型质量评价指标进行数值处理,基于有限元分析结果和响应面法构建了充填平衡性预测模型,应用构建的模型确定了最优工艺参数组合,并进行了数值模拟和生产试验验证。近似模型获得的目标预测值与模拟验证值相对误差为4.2%,优化后异型腔模具充填平衡性提高了23%,表明了所提出方法的有效性。     

Formulation of Insulin-Loaded Polymeric Nanoparticles Using Response Surface Methodology

The objective of this work was to formulate new oral insulin-loaded nanoparticules using the response surface methodology. The insulin nanoparticles were prepared by a water-in-oil-in-water emulsification and evaporation method. The polymers used for the encapsulation were blends of biodegradable poly-epsilon-caprolactone (PCL) and of positively-charged, nonbiodegradable polymer (Eudragis RS®). A central composite design has been built to investigate the effects of three controlled variables: ratio of polymers (PCL/RS ratio), volume, and pH of the aqueous solution of polyvinyl alcohol. The nanoparticles were characterized by measuring the amount of entrapped insulin, the particle size, the polydispersity of the obtained particles, the zeta potential, and the amount of insulin released after 7 hours. A second-order model was evaluated by multiple regression and was statistically tested for each of the studied controlled variable. The obtained polynomials proved efficient to localize an optimal operating area highlighted by the use of three-dimensional response surfaces and their corresponding isoresponse curves. An interesting formulation given by the models was selected, prepared, and evaluated. The corresponding quantity of entrapped insulin was 25 IU per 100 mg of polymer, and the particle size was 350 nm with a polydispersity of 0.21. The quantity of released insulin was 4.8 IU per 100 mg of polymer after 7 hours and the zeta potential was + 44 mV. All these collected values were in perfect accordance with values estimated by the models. Finally, the results suggested that PCL/RS 50/50 nanoparticles might represent a promising formulation for oral delivery of insulin.