共查询到20条相似文献,搜索用时 640 毫秒
1.
2.
Bin Wang Benjamin V. Cunning Na Yeon Kim Fariborz Kargar Sun‐Young Park Zhancheng Li Shalik R. Joshi Li Peng Vijayakumar Modepalli Xianjue Chen Yongtao Shen Won Kyung Seong Youngwoo Kwon Jeongsu Jang Haofei Shi Chao Gao Gun‐Ho Kim Tae Joo Shin Kwanpyo Kim Ju‐Young Kim Alexander A. Balandin Zonghoon Lee Rodney S. Ruoff 《Advanced materials (Deerfield Beach, Fla.)》2019,31(29)
A macroscopic film (2.5 cm × 2.5 cm) made by layer‐by‐layer assembly of 100 single‐layer polycrystalline graphene films is reported. The graphene layers are transferred and stacked one by one using a wet process that leads to layer defects and interstitial contamination. Heat‐treatment of the sample up to 2800 °C results in the removal of interstitial contaminants and the healing of graphene layer defects. The resulting stacked graphene sample is a freestanding film with near‐perfect in‐plane crystallinity but a mixed stacking order through the thickness, which separates it from all existing carbon materials. Macroscale tensile tests yields maximum values of 62 GPa for the Young's modulus and 0.70 GPa for the fracture strength, significantly higher than has been reported for any other macroscale carbon films; microscale tensile tests yield maximum values of 290 GPa for the Young's modulus and 5.8 GPa for the fracture strength. The measured in‐plane thermal conductivity is exceptionally high, 2292 ± 159 W m?1 K?1 while in‐plane electrical conductivity is 2.2 × 105 S m?1. The high performance of these films is attributed to the combination of the high in‐plane crystalline order and unique stacking configuration through the thickness. 相似文献
3.
4.
5.
6.
Cavalieri F Ng SL Mazzuca C Jia Z Bulmus V Davis TP Caruso F 《Small (Weinheim an der Bergstrasse, Germany)》2011,7(1):101-111
The assembly of multifunctional nanostructures bearing G-quadruplex motifs broadens the prospects of using G-quadruplexes as therapeutic carriers. Herein, we report the synthesis and characterization of an oligodeoxyguanosine, G15-mer polymer conjugate. We demonstrate that G15-mer oligonucleotides grafted to a polymer chain preserve the ability to self-assemble into ordered structures. The G-quadruplex-polymer conjugates were assembled onto a surface via hybridization with 30-mer cytosine strands, C30-mer, using a layer-by-layer approach to form microcapsules. A mechanism for the sequential assembly of the multilayer films and microcapsules is presented. We further investigate the photophysical behavior of porphyrin TMPyP4 bound to multilayer-coated particles. This study shows that the multilayer films bear residual and functional quadruplex moieties that can be used to effectively bind therapeutic agents. 相似文献
7.
8.
9.
10.
Binding,Internalization, and Antigen Presentation of Vaccine‐Loaded Nanoengineered Capsules in Blood
Robert De Rose Alexander N. Zelikin Angus P. R. Johnston Amy Sexton Siow‐Feng Chong Christina Cortez William Mulholland Frank Caruso Stephen J. Kent 《Advanced materials (Deerfield Beach, Fla.)》2008,20(24):4698-4703
11.
12.
13.
14.
15.
16.
17.
18.
Nitric Oxide Releasing Coronary Stent: A New Approach Using Layer‐by‐Layer Coating and Liposomal Encapsulation 下载免费PDF全文
Mahmoud A. Elnaggar Seong Ho Seo Samy Gobaa Kyung Seob Lim In‐Ho Bae Myung Ho Jeong Dong Keun Han Yoon Ki Joung 《Small (Weinheim an der Bergstrasse, Germany)》2016,12(43):6012-6023
The sustained or controlled release of nitric oxide (NO) can be the most promising approach for the suppression or prevention of restenosis and thrombosis caused by stent implantation. The aim of this study is to investigate the feasibility in the potential use of layer‐by‐layer (LBL) coating with a NO donor‐containing liposomes to control the release rate of NO from a metallic stent. Microscopic observation and surface characterizations of LBL‐modified stents demonstrate successful LBL coating with liposomes on a stent. Release profiles of NO show that the release rate is sustained up to 5 d. In vitro cell study demonstrates that NO release significantly enhances endothelial cell proliferation, whereas it markedly inhibits smooth muscle cell proliferation. Finally, in vivo study conducted with a porcine coronary injury model proves the therapeutic efficacy of the NO‐releasing stents coated by liposomal LBL technique, supported by improved results in luminal healing, inflammation, and neointimal thickening except thrombo‐resistant effect. As a result, all these results demonstrate that highly optimized release rate and therapeutic dose of NO can be achieved by LBL coating and liposomal encapsulation, followed by significantly efficacious outcome in vivo. 相似文献
19.
Joana M. Silva Rui L. Reis João F. Mano 《Small (Weinheim an der Bergstrasse, Germany)》2016,12(32):4308-4342
Surface modification of biomaterials is a well‐known approach to enable an adequate biointerface between the implant and the surrounding tissue, dictating the initial acceptance or rejection of the implantable device. Since its discovery in early 1990s layer‐by‐layer (LbL) approaches have become a popular and attractive technique to functionalize the biomaterials surface and also engineering various types of objects such as capsules, hollow tubes, and freestanding membranes in a controllable and versatile manner. Such versatility enables the incorporation of different nanostructured building blocks, including natural biopolymers, which appear as promising biomimetic multilayered systems due to their similarity to human tissues. In this review, the potential of natural origin polymer‐based multilayers is highlighted in hopes of a better understanding of the mechanisms behind its use as building blocks of LbL assembly. A deep overview on the recent progresses achieved in the design, fabrication, and applications of natural origin multilayered films is provided. Such films may lead to novel biomimetic approaches for various biomedical applications, such as tissue engineering, regenerative medicine, implantable devices, cell‐based biosensors, diagnostic systems, and basic cell biology. 相似文献
20.
Loretta L. del Mercato Maria Moffa Rosaria Rinaldi Dario Pisignano 《Small (Weinheim an der Bergstrasse, Germany)》2015,11(48):6417-6424
A fundamental issue in biomedical and environmental sciences is the development of sensitive and robust sensors able to probe the analyte of interest, under physiological and pathological conditions or in environmental samples, and with very high spatial resolution. In this work, novel hybrid organic fibers that can effectively report the analyte concentration within the local microenvironment are reported. The nanostructured and flexible wires are prepared by embedding fluorescent pH sensors based on seminaphtho‐rhodafluor‐1‐dextran conjugate. By adjusting capsule/polymer ratio and spinning conditions, the diameter of the fibers and the alignment of the reporting capsules are both tuned. The hybrid wires display excellent stability, high sensitivity, as well as reversible response, and their operation relies on effective diffusional kinetic coupling of the sensing regions and the embedding polymer matrix. These devices are believed to be a powerful new sensing platform for clinical diagnostics, bioassays and environmental monitoring. 相似文献