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1.
第三代铂抗癌药物研究评论   总被引:4,自引:0,他引:4  
杨一昆  熊惠周 《贵金属》1996,17(2):50-57
本文评论顺铂和卡铂之后的第三代铂抗癌药物的研究状况。报道其配合物的抗肿瘤活性、限量毒性、交叉耐药性和其中四种配合物的Ⅱ期临床结果。这些配合物的总体水平并不优于顺铂和卡铂。研究抗癌机理与顺铂和卡铂不同的新型铂配合物是增加该类药物的抗肿瘤活性和克服交叉耐药性的途径之一。  相似文献   

2.
[Pt(en)(5-Fu)2]Cl2配合物的合成及抗肿瘤活性   总被引:1,自引:0,他引:1  
为寻求高效低毒的新型顺铂类抗肿瘤药物,用K2PtCl4、乙二胺(en)、氟尿嘧啶(5-Fu)为原料,设计合成了顺铂类似物[Pt(en))(5-Fu)2]Cl2配合物,由元素分析、红外光谱和质谱分析初步证实了其化学结构,用改良MTT、SRB法,选用K562、A549、Bel-7402、BIU-87、Bcap-37细胞株对其进行体外抗肿瘤活性测定。结果表明,所合成的配合物除在浓度为0.01、0.1/μg/mL时对K562细胞株抗肿瘤活性大于顺铂和氟尿嘧啶外,其它情况下的抗肿瘤活性均小于顺铂和氟尿嘧啶。该配合物仍有进一步研究的价值。  相似文献   

3.
新型铂族金属抗肿瘤药物赛特铂的研究现状   总被引:2,自引:2,他引:0  
铂族金属抗肿瘤药物顺铂和卡铂已广泛应用于临床,它们对治疗睾丸肿瘤、卵巢癌和肺癌等十几种肿瘤有显著的疗效。近年来又有奈达铂、 到铂和乐铂等获批准进入临床应用。但目前这些临床应用的铂族金属抗肿瘤药口服活性低,都是静脉途径给药。本文介绍了已进入Ⅲ期临床试验的第一个口服活性铂抗肿瘤药物赛特铂及其合成、化学特点、临床前和临床研究情况。  相似文献   

4.
近年来,贵金属药物的合成和应用研究有长足的进步。铂抗癌药物顺铂和卡铂在临床上已进入Ⅱ、Ⅲ期试用阶段,取得了令人鼓舞的效果。治疗关节炎的药物Auranofin和消炎、杀菌的磺胺嘧啶银已被广泛使用,为人类的健康作出了贡献。 贵金属药物能消炎和杀菌 金的有机金属化合物作治疗关节炎的药物可分为两大类。注射型有硫代丙醇硫酸钠金(商品名,Allochry-  相似文献   

5.
1.引言顺铂和碳铂是有效的抗癌药物.高效液相色谱法分析顺铂有使用乙酸-乙酸钠缓冲液流动相的强阴离子交换,反相离子对色谱法等.作者考虑顺铂和碳铂是中性配合物,在强阴离子交换色谱中不用缓冲液流动相,研究了四烷基铵键合硅胶柱-中性盐水流动相时,顺铂、碳铂和反铂的保留行为和外标法定量顺铂和碳铂的准确性.  相似文献   

6.
金宜纫  黄天木 《贵金属》1993,14(2):50-54
用高效液相色谱法研究了碳铂对热和光的稳定性。当温度低于110℃,碳铂粉剂对热和光是稳定的。6年留样分析碳铂含量不变。在湿度80~100%下碳铂会缓慢潮解。碳铂水溶液对热和光均不稳定,28~35℃/120h碳铂分解13.35%,38℃/24h分解10.66%。分解产物是水配合物和羟桥聚合物;水溶液中加入NaCl生成顺铂。  相似文献   

7.
1.引言 1978年底,美国政府批准第一个铂族金属抗癌药物顺式-二氯二氨合铂(简称顺铂)作为商品投入市场,迄今10年来的临床实践表明,顺铂由于疗效好、抗癌谱广,与其他药物联用无交叉抗药性,因而得到广泛应用,成为与阿霉素并列的最好的抗癌药物之一.顺铂的成就鼓舞着各国学者去研究更有效的铂族抗癌药物,这10年是铂族抗癌药物  相似文献   

8.
合成了以甲胺/环戊胺为伴随基团,分别以氯离子、1,1-环丁基二羧酸根和草酸根作为离去基团的3种新的铂(II)配合物。以顺-二碘-二环戊胺合铂(II)、硝酸银、甲胺、氯化钾、1,1-环丁基二羧酸钾和草酸钾为原料合成目标化合物。采用元素分析、质谱、核磁共振氢谱和红外光谱分析其组成和结构,利用MTT体外检测法进行了初步的体外活性评价,表明合成的3种化合物结构与理论一致,具有一定的体外肿瘤生长抑制活性。  相似文献   

9.
铂类抗癌配合物的高效液相色谱法研究进展   总被引:1,自引:1,他引:0  
铂类抗癌药物是目前临床治疗恶性肿瘤最有效的药物之一,近10年来,其应用和研究得到了迅速的发展.铂类抗癌配合物的化学分析方法主要有炽灼残渣检查法、高效液相色谱法、薄层层析法、紫外分光光度法及毛细管电泳法等,其中,高效液相色谱法( HPLC)因分析速度快、分离效率高、检测灵敏度高、检测自动化、适用范围广等优点,已成为近年来...  相似文献   

10.
铂(Ⅱ)类抗癌药物的溶液化学反应特性   总被引:1,自引:0,他引:1  
铂(Ⅱ)类抗癌药物的溶液化学反应特性是此类药物化学基础理论的重要组成部分,本文综述了此类药物的溶液化学反应研究状况,包括顺铂、碳铂、草酸铂等的水合反应以及与Cl∧-、生物分子等的取代反应。  相似文献   

11.
Institute of Process Engineering, Chinese Academy of Sciences, China, has proposed a method for oxidative leaching of chromite with potassium hydroxide. Understanding the mechanism of chromite decomposition, especially in the potassium hydroxide fusion, is important for the optimization of the operating parameters of the oxidative leaching process. A traditional thermodynamic method is proposed and the thermal decomposition and the reaction decomposition during the oxidative leaching of chromite with KOH and oxygen is discussed, which suggests that chromite is mainly destroyed by reactions with KOH and oxygen. Meanwhile, equilibrium of the main reactions of the above process was calculated at different temperatures and oxygen partial pressures. The stable zones of productions, namely, K2CrO4 and Fe2O3, increase with the decrease of temperature, which indicates that higher temperature is not beneficial to thermodynamic reactions. In addition, a comparison of the general alkali methods is carried out, and it is concluded that the KOH leaching process is thermodynamically superior to the conventional chromate production process.  相似文献   

12.
The effect of isochronal heat treatments for 1h on variation of damping, hardness and microstructural change of the magnesium wrought alloy AZ61 was investigated. Damping and hardness behaviour could be attributed to the evolution of precipitation process. The influence of precipitation on damping behaviour was explained in the framework of the dislocation string model of Granato and Lücke.  相似文献   

13.
In as-welded state, each region of 2219 aluminum alloy TIG-welded joint shows diff erent microstructure and microhardness due to the diff erent welding heat cycles and the resulting evolution of second phases. After the post-weld heat treatment, both the amount and the size of the eutectic structure or θ phases decreased. Correspondingly, both the Cu content in α-Al matrix and the microhardness increased to a similar level in each region of the joint, and the tensile strength of the entire joint was greatly improved. Post-weld heat treatment played the role of solid solution strengthening and aging strengthening. After the post-weld heat treatment, the weld performance became similar to other regions, but weld reinforcements lost their reinforcing eff ect on the weld and their existence was more of an adverse eff ect. The joint without weld reinforcements after the post-weld heat treatment had the optimal tensile properties, and the specimens randomly crack in the weld zone.  相似文献   

14.
After nearly two years' tense construction, the first phase of industrialized base of Shenyang Research Institute of Foundry (SRIF), located at the Tiexi Casting and Forging Industrial Park in the west of Tiexi District, has now been completed and formally put into operation.  相似文献   

15.
韩磊 《腐蚀与防护》2015,36(1):84-90,94
综述了常见的电化学噪声数据处理方法,介绍了直流趋势剔除、统计分析、快速傅立叶变换(FFT)法计算功率谱密度(PSD)以及小波变换处理电化学噪声信号的基本过程,并阐释了各种数学处理及所得参数的物理意义。  相似文献   

16.
正I take great pleasure in congratulating CHINA FOUNDRY journal on its 10th anniversary.The CHINA FOUNDRY journal started ten years ago.Since its inaugural,China has seen exceptional growth in the Castings Sector and rapid development in Machinery Industry.The journal is becoming an important communication platform for experts  相似文献   

17.
正Harbin General Hydraulic Machinery Works Co.,Ltd.of Yilin Hydraulic Group is the most professional production base of large-scale metallurgy oil cylinder and oil machinery cylinder in the Northeast of China.The main products include metallurgy cylinder,swell-shrink cylinder,rotating injection device,lifting cylinder,main lifting jack,front lifting jack,engineering oil cyl-  相似文献   

18.
正Weihai HHH Mach.Elec.Group is the most technical company focusing on Power transmission and Hydra-controlling.HHH has the ability of developing and testing of complete sets of transmission system with relevant technical training.HHH provide efficient,excellent cost-effective power transmission system and intelligent electric fluid transmission and control system to OEM customers,who are  相似文献   

19.
《中国铸造》2014,(5):460-463
The 9th China International Diecasting Congress and the 1st International Symposium on Nonferrous Alloys and Special Casting Technologies (ISNASCT) were successfully held in Shanghai on July 19-22, 2014. Both events were jointly sponsored by Chinese Mechanical Engineering Society, Die Casting Commission of World Foundry Organization and Non-Ferrous Materials Commission of World Foundry Organization, and organized by the Foundry Institution of Chinese Mechanical Engineering Society (FICMES) and China Productivity Promotion Center of Foundry Industry.  相似文献   

20.
《中国铸造》2014,(6):539-539
The ANKIROS/ANNOFER/TURKCAST shows held on Sept. 11-14, 2014, in Istanbul, Turkey, provided an ideal opportunity for the World Foundry Organization Executive Board to meet and discuss member benefits. Nine executive board members attended the meeting, including Dr. Lou Yanchun, Vice President of FICMES and President of Shenyang Research Institute of Foundry. During the board meeting, the WFO executives agreed to establish a special working group which is responsible for drafting a strategical plan for the WFO and submitting it for discussion at the next board meeting in 2015.  相似文献   

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