共查询到20条相似文献,搜索用时 31 毫秒
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H. Okamoto 《Journal of Phase Equilibria and Diffusion》1992,13(3):325-326
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《Scripta materialia》2003,48(9):1243-1248
A simplified method for analyzing the development of roping is proposed based on the observation that the initial texture and its spatial distribution are the predominant factors for roping. The method is validated by comparing its results with experimental observations, and with numerical results based on the finite element method. 相似文献
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目的:应用体外人肝微粒体及重组人源代谢酶孵育体系观察维罗非尼对尿苷二磷酸葡萄糖醛酸基转移酶1A1(UDP-glucuronosyltransferases,UGT1A1)介导的伊立替康代谢的抑制作用,通过体外-体内外推(in vitro-in vivo extrapolation,IV-IVE)预测体内药物-药物相互作用(drug-drug interaction,DDI)的发生风险。方法:以混合人肝微粒体 (human liver microsomes,HLMs)及重组表达的人UGT1A1 作为酶源,观察维罗非尼对UGT1A1介导的伊立替康活性代谢产物SN-38葡糖醛酸化反应的抑制作用,求得半数最大抑制浓度(half maximum inhibitory concentration,IC50)和抑制动力学常数Ki及抑制类型;并基于体外参数预测了体内维罗非尼与伊立替康联合应用引发的潜在DDI风险。结果:维罗非尼对UGT1A1具有较强的非竞争性抑制作用,IC50 为4.35 μmol/L,Ki为9.77 μmol/L。口服治疗剂量的维罗非尼 (960 mg,每日两次)可导致SN-38的药时曲线下面积(area under the curve,AUC)增加7%~149% 。结论:维罗非尼与伊立替康联合应用时,可通过强效抑制UGT1A1而影响伊立替康在体内的代谢清除,具有引发DDI的风险。 相似文献
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全面介绍铝及铝合金标牌感光染色工艺的整个过程。用此工艺制得的标牌具有色彩鲜艳齐全,表面光洁平整,装饰功能强的优点。本工艺同样适用于家用电器、仪器仪表的表面装饰处理。 相似文献
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F. Yang C. H. Wu D. L. Sun School of Materials Science & Engineering Harbin Institute of Technology Harbin China 《金属学报(英文版)》2000,13(2):502-507
1.~hon2024Alalloyusedincomponentsofaprecisiondeviceishighlyrearredfordimensionalstability.althoughdimensionalstabilityhadbeenstudiedinseverallit.rat~.[l--3),therelationshipsbetweenndcrostructureanddimensionalstabilitypropertiesandAnsotmpofmicro--plasticdeformationresistanceforhotextruded2024Alalloybarwerenotinvestigatedindetails.SOInanyengineeringproblemsPertinentto2024hialloyremaininsuspense.Additionallytheconventionalevaluationfordimensionalstabilityinunloadingconditionisobtainedbyend--len… 相似文献
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In order to develop a new high strength and high tolerance-resistance Al-Li alloy which can be used in aerospace industry, the effects ofmicroalloying elements such as Mg, Ag, Mn and Zn on the mechanical properties of Al-Cu-Li alloys were studied. The results show that the strengthening effects of Mg+Ag and Mg+Zn additions are higher than those of the individual Mg, Ag or Zn addition. The element Mn can also bring some extent strengthening effects on the alloys, but it has nothing to do with the other microalloying elements present or not. Finally, a new Al-Li alloy with Mg+Zn+Mn additions was developed, which possesses high strength and high tolerance-resistance promising properties for aerospace applications. 相似文献
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The ternary alloys of the rare earths with lead and palladium were studied for the stoichiometric ratios 1:1:1 and 1:1:2 with respect to the structure of these alloys and their existence field. RPbPd (R = La, Ce, Pr, Nd, Sm, Gd, Tb, Dy, Y, Ho, Er, Tm, Yb) compounds have a hexagonal structure, hP9 Fe2P type, while RPbPd2 (R = Pr, Sm, Gd, Tb, Dy, Ho, Er, Yb) alloys have the cubic AlCu2Mn-type structure (cF16, BiF3 superstructure). 相似文献
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The kinetics process of absorbing hydrogen of Al melt was analyzed and it was considered that the concentration of hydrogen in Al melt was determined by the concentration of water vapor in the interface of the oxide layer and Almelt. The change of the alloying composition will result in the change of compactability of oxide layer and affect the process of the water vapor gas penetrating the oxide layer and entering the interface of Al melt and oxide layer. Based on theabove analysis, the kinetics equation of Al melt absorbing hydrogen was established, and compared with the test result.The results of calculation were elementally coincident with the test result. The curve of hydrogen concentration varyingwith reaction time in Al melt can be obtained from this equation. And scientific basis could be provided to select meltingtechnology parameter properly and control the concentration of hydrogen in Al melt. 相似文献
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7A52 A1 alloy plate aged at 105℃ for 8 h and then at 130℃ for 24 h was welded by means of TIG using A1- 6.3Mg-0.35Sc-0.1Zr-0.1Cr solder wire. Mechanical properties and microstructures of welded joint were studied. There are two obviously soft areas in the welded joint, welding seam and over-aging zone. The mechanical properties of welded joint are that σb is 358 MPa, σ0.2 is 238 MPa and δ5 is 6.6%. 75.6% of welding coefficient can be achieved. The addition of scandium leads to very significant grain refinement in the fusion zone, which results in a reduction in solidification cracking tendency. The solidification cracking isn't observed. 相似文献
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The influence of melt superheating treatment on the microstructures of Mg-3.5Si-1A1 alloys unmodified and modified with 0.2% Sr-Sb (mass fraction) was investigated. The results show that when the melt superheating temperature increases from 750 to 900 ℃, the average size of primary Mg2Si in the unmodified alloys decreases progressively from about 27 to about 19 μm, while that in Sr-Sb-modified alloys,is refined considerably from about 14 to about 7 μm when the temperature increases from 750 to 850℃, and then slightly increases to about 9 μm with temperature further increasing to 900 ℃, which might be attributed to the burning loss of Sr and Sb in melts. However, the superheating temperature only has a slight effect on the morphologies of both primary and eutectic Mg2Si phases in unmodified and Sr-Sb-modified alloys. 相似文献
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XUXiaojing WANG Wei and CAI LanSchool of Mechanical Engineering Jiangsu University Zhenjiang China 《稀有金属(英文版)》2004,(1)
The superplastic characteristics of a 15% (volume fraction) SiCp (14 μm) /6A02A1 composite, fabricated by stirring casting and cold-rolling after extrusion with a low extrusion ratio of 10:1 and hot-rolling, were investigated. The composite exhibits a tensile elongation of 250% at an initial strain rate of 8.9 ×10-4 s-1 and at 833 K where an appropriate amount of liquid phase is presented in the composite. The superplastic deformation is uniform and the strain hardening exponent γis as high as 1.6. The fracture surface is intergranual and the superplastic deformation mechanism of the composite is considered to be grain boundary (interface) sliding accommodated by an appropriate amount of liquid phase. 相似文献