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Myelodysplastic syndromes (MDS) are highly heterogeneous myeloid neoplasms, and a large number of
patients are difficult to diagnose and classify by blood and bone marrow examination. As a surface marker of
granulocyte, studies have shown CD10 can be used to define the degree of granulocyte maturation in MDS patients.
However, whether it can be used for differential diagnosis of MDS and other hematological diseases remains
inconclusive. To explore the value of CD10 for differential diagnosis of MDS, 60 newly diagnosed MDS, 20 aplastic
anemia (AA) patients, and 35 iron-deficient anemia (IDA) patients were selected for this study. Bone marrow (BM)
specimens were processed for surface marker analysis and labeled with pre-conjugated monoclonal antibodies. Stained
cells were detected by flow cytometry. Our results indicated that CD10-positive granulocytes were significantly
decreased in BM of MDS patients than AA and IDA patients, and the level of CD10-positive mature granulocytes was
not associated with the clinical stages of malignancy. Receiver operating characteristic (ROC) areas under the curve
(AUC) of CD10-positive granulocytes was 0.86 and 0.85, respectively, in MDS patients than the IDA group and AA
group with good specificity and sensitivity. Further, CD10-positive granulocytes were increased after effective
treatment. In conclusion, we found the decrease in CD10-positive granulocytes has a differential diagnostic value of MDS. 相似文献
4.
基于C4AF可以提高水泥基材料的抗蚀性,以高铁低钙水泥熟料为研究对象,掺入不同含量的CuO,通过对熟料及其水化产物进行X射线衍射(XRD)、水化热、抗压强度、非蒸发水含量和固化氯离子能力等测试,探究Cu2+对高铁低钙水泥熟料水化性能与氯离子吸附固化能力的影响.结果发现,适量CuO的掺入促进了高铁低钙水泥熟料中C4AF的生成,降低了熟料液相的粘度,有利于C3S的晶粒生长,有利于提高高铁低钙水泥熟料的水化活性和固化氯离子能力,最佳掺量为0.2 wt%. 相似文献
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目的: 建立快速灵敏的LC-MS/MS法测定人血浆中阿莫西林浓度,并用于两种阿莫西林胶囊的一致性评价。方法: 采用岛津公司LCMS-8060型LC-MS/MS仪,以MRM模式测定阿莫西林(m/z 366.00/114.00)的浓度,d4-阿莫西林作内标(m/z 370.10/114.05),离子源为ESI源。色谱柱选用Waters ACQUITY BEH C18(2.1×50 mm,1.7 μm),梯度洗脱。血浆样本加入内标,经甲醇沉淀蛋白后取上清液进样检测。结果: 所建方法经验证,其线性、准确度、精密度、最低定量限、提取回收率、特异性、基质效应、稳定性等各项指标均符合CFDA的指导原则及最新核查标准要求,并较文献报道中的方法有处理简单、灵敏度高、色谱峰形好的优点。结论: 所建方法快速、灵敏,适用于人血浆中阿莫西林浓度的检测。用于一致性评价的样本实测,两种制剂生物等效。 相似文献
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Mingzhi Zhao Jianwei Cao Zhi Wang Guohua Li 《Journal of the European Ceramic Society》2019,39(7):2427-2435
The crystallization phenomena of spinel in CaO-MgO-Al2O3-SiO2-Fe2O3 glass have received much attention due to the particular role in preparation of glass-ceramic materials, which represent an effective option to manage hazardous waste. In this study, both preliminary spinel and secondary spinel were precipitated in the precursor glass. The formation of these spinel was meticulously assessed by a combination of X-ray diffractometry and scanning electron microscopy. The structure of the microenvironment in the precursor glass was characterized by Raman spectrums. These advanced techniques highlight the potential for one-step crystallization of the glass. The investigation, which focused on one-step crystallization, demonstrated the growth of pyroxene on spinel accompanying a migration of chromium. The results also show the microstructure of the obtained glass-ceramic was very dependent on the heat-treat temperature. This study not only unambiguously reveals the precipitation mechanisms of spinel but also provides more documentation for one-step crystallization in the glass-ceramics field. 相似文献
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Haibo Zhang Guohua Geng Kang Li Cheng Liu Yuqing Hou 《Journal of Modern Optics》2018,65(20):2278-2289
Cone-beam X-ray luminescence computed tomography (CB-XLCT) is an attractive hybrid imaging modality, and it has the potential of monitoring the metabolic processes of nanophosphors-based drugs in vivo. However, the XLCT imaging suffers from a severe ill-posed problem. In this work, a sparse nonconvex Lp (0?p?1) regularization was utilized for the efficient reconstruction for early detection of small tumour in CB-XLCT imaging. Specifically, we transformed the non-convex optimization problem into an iteratively reweighted scheme based on the L1 regularization. Further, an iteratively reweighted split augmented lagrangian shrinkage algorithm (IRW_SALSA-Lp) was proposed to efficiently solve the non-convex Lp (0?p?1) model. We studied eight different non-convex p-values (1/16, 1/8, 1/4, 3/8, 1/2, 5/8, 3/4, 7/8) in both 3D digital mouse experiments and in vivo experiments. The results demonstrate that the proposed non-convex methods outperform L2 and L1 regularization in accurately recovering sparse targets in CB-XLCT. And among all the non-convex p-values, our Lp(1/4?p?1/2) methods give the best performance. 相似文献
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采用改性NE-II型环氧砂浆,对紫坪铺1号泄洪洞导泄结合段(原1号导流洞)进行抗冲耐磨补强处理。其材料性能、施工方法及工艺流程、质量控制与质量检测等,满足设计和技术规程要求,同时提出了在环氧砂浆施工及质量控制中应注意的问题及体会,可供类似高流速水工建筑物过流面抗冲磨补强处理借鉴、参考。 相似文献
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