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1.
This paper is prepared in honour of Professor E.T. Brown for his outstanding contributions to rock mechanics and geotechnical engineering and also for his personal influence on the first author's research career in geomechanics and geotechnical engineering. As a result, we have picked a topic that reflects two key research areas in which Professor E.T. Brown has made seminal contributions over a long and distinguished career. These two areas are concerned with the application of the critical state concept to modelling geomaterials and the analysis of underground excavation or tunnelling in geomaterials.Partially due to Professor Brown's influence, the first author has also been conducting research in these two areas over many years. In particular, this paper aims to describe briefly the development of a unified critical state model for geomaterials together with an application to cavity contraction problems and tunnelling in soils. 相似文献
2.
3.
Dr. Yahu A. Liu Dr. Qihui Jin Qiang Ding Dr. Xueshi Hao Tingting Mo Shanshan Yan Dr. Yefen Zou Dr. Zhihong Huang Xiaoyue Zhang Wenqi Gao Dr. Tom Y.-H. Wu Chun Li Dr. Badry Bursalaya Dr. Michael Di Donato Dr. You-Qing Zhang Lisa Deaton Dr. Weijun Shen Dr. Brandon Taylor Anwesh Kamireddy Dr. George Harb Dr. Jing Li Dr. Yong Jia Dr. Andrew M. Schumacher Dr. Bryan Laffitte Dr. Richard Glynne Dr. Shifeng Pan Dr. Peter McNamara Dr. Valentina Molteni Dr. Jon Loren 《ChemMedChem》2020,15(16):1562-1570
Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β-cell mass are less developed. Promoting β-cell proliferation with low-molecular-weight inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) offers the potential to treat diabetes with oral therapies by restoring β-cell mass, insulin content and glycemic control. GNF4877, a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) was previously reported to induce primary human β-cell proliferation in vitro and in vivo. Herein, we describe the lead optimization that lead to the identification of GNF4877 from an aminopyrazine hit identified in a phenotypic high-throughput screening campaign measuring β-cell proliferation. 相似文献
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5.
UML在网络安全监控系统建模中的应用 总被引:4,自引:0,他引:4
本文首先介绍了UML的特性,然后运用UML对网络安全监控系统中的数据采集系统进行了可视化的建模,建立了系统的需求模型和设计模型的各种视图,最后总结了用UML进行系统需求分析和设计的优越性. 相似文献
6.
Yong Zhang Yuanlong Mo Xiaolan Zhou Jianqing Li 《Journal of Infrared, Millimeter and Terahertz Waves》2003,24(12):2085-2094
Recently disk-loaded waveguide has been widely used in high-power traveling wave tubes (HPTWT). It has been shown in many experiments that the interaction efficiency and output power can be increased greatly by injecting plasma into the vacuum microwave device. Using field analysis, the dispersion characteristics and the interaction impedance of the disk-loaded waveguide filled with plasma are analyzed in a strong longitudinal magnetic field. In conclusion, the frequency of the TM01 mode increases as the density of the plasma increases. It also can be found when the plasma density increases to a large scale, the TM01 mode of the disk-loaded waveguide overlaps the TG mode, these two modes couple each other and form the new hybrid modes. 相似文献
7.
8.
Wenlin HE Qishan ZANG+ Zhongguang WANG State Key Laboratory for Fatigue Fracture of Materials 《材料科学技术学报》1993,9(2):107-110
The distributions of plastic strain near grain boundaries induced by fatigue loading were investigatedby the fiducial grid method in pure aluminum specimens, and the resulted grain boundary sliding(GBS) was systematically analysed. The results show that the strain field near a grain boundary isnonuniform. GBS is restricted by the junction of grain boundaries and causes discontinuities of bothdisplacement and strain. A peak value of shear strain was created in short-range area across the grainboundary. GBS plays an important role in cyclic softening and secondary hardening. The control fac-tor of GBS is the relative orientation between two grains and the macro orientation of the grainboundary rather than the ∑ value of the boundary. 相似文献
9.
A Linear Cross-Coupled Control System for High-Speed Machining 总被引:4,自引:0,他引:4
Q. Zhong Y. Shi J. Mo S. Huang 《The International Journal of Advanced Manufacturing Technology》2002,19(8):558-563
We present a linear cross-coupled controller to improve highspeed contouring accuracy independently of tracking accuracy in
a biaxial machine tool feed drive servomechanism. Unlike conventional cross-coupled controllers, the cross-coupled controller
presented here is a linear system, so it is very easy to perform the stability and steady-state error analysis, and to optimise
the controller parameters. The proposed controller is evaluated experimentally on a CNC LOM machine and compared to an uncoupled
controller and a conventional cross-coupled controller. Controller performance is evaluated for a circular contour at a feedrate
of 30 m min _1 . The experimental results show that the proposed controller can greatly reduce the contour error at large feedrates. The
linear cross-coupled controller is simple to implement and is practical. 相似文献
10.
Zhang Li Chun Jin Hai Yan Ye Hong Fei Gao Yu Zhi Ning Bao Jun Mo Bang Xian 《Electron Devices, IEEE Transactions on》2002,49(6):1075-1076
A polysilicon emitter RCA transistor (an ultra-thin interfacial oxide layer exists between polysilicon and silicon emitter) is presented which can operate at 77 K for the first time. An ultra-thin (1.5 nm) interfacial oxide layer is grown deliberately between polysilicon and silicon emitter using RCA oxidation and excellent device stability is obtained after rapid thermal annealing (RTA) treatment in nitrogen atmosphere. The RCA transistor exhibits good electrical performance at very low temperature for an emitter area of 3 × 8 μm2. The maximum toggle frequency of a 1:2 static divider is 1.2 GHz and 732 MHz at 300 K and 77 K, respectively 相似文献